Current challenges: from the path of “original antigenic sin” towards the development of universal flu vaccines

Serum anti-neuraminidase antibody responses in human influenza A(H1N1)pdm09 virus infections

(2019) Herath M. T. K. Karunarathna et al.   Emerging Microbes & Infections

CD4+T help promotes influenza virus-specific CD8+T cell memory by limiting metabolic dysfunction

(2019) Jolie G. Cullen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human CD8+ T cell cross-reactivity across influenza A, B and C viruses

(2019) Marios Koutsakos et al.   NATURE IMMUNOLOGY

Broad hemagglutinin-specific memory B cell expansion by seasonal influenza virus infection reflects early-life imprinting and adaptation to the infecting virus

(2019) Brenda L. Tesini et al.   JOURNAL OF VIROLOGY

Influenza virus infection as well as immunization with DNA encoding haemagglutinin protein induces potent antibody-dependent phagocytosis (ADP) and monocyte infection-enhancing responses in macaques

(2019) Gerrit Koopman et al.   JOURNAL OF GENERAL VIROLOGY

Adjuvanted versus nonadjuvanted influenza vaccines and risk of hospitalizations for pneumonia and cerebro/cardiovascular events in the elderly

(2019) Francesco Lapi et al.   Expert Review of Vaccines

Challenges in the development of egg-independent vaccines for influenza

(2019) Claudia Maria Trombetta et al.   Expert Review of Vaccines

Live attenuated influenza vaccine induces tonsillar follicular T helper cell responses that correlate with antibody induction

(2019) Sarah Lartey et al.   JOURNAL OF INFECTIOUS DISEASES

Outflanking immunodominance to target subdominant broadly neutralizing epitopes

(2019) Davide Angeletti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model

(2019) Wen-Chun Liu et al.   Frontiers in Immunology

Sequential Immunization with Universal Live Attenuated Influenza Vaccine Candidates Protects Ferrets against a High-Dose Heterologous Virus Challenge

(2019) Irina Isakova-Sivak et al.   Vaccines

CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential

(2018) Andrea J. Sant et al.   IMMUNOLOGICAL REVIEWS

Overarching Immunodominance Patterns and Substantial Diversity in Specificity and Functionality in the Circulating Human Influenza A and B Virus–Specific CD4+ T-Cell Repertoire

(2018) Katherine A Richards et al.   JOURNAL OF INFECTIOUS DISEASES

Activation and Induction of Antigen-Specific T Follicular Helper Cells Play a Critical Role in Live-Attenuated Influenza Vaccine-Induced Human Mucosal Anti-influenza Antibody Response

(2018) Abdullah Aljurayyan et al.   JOURNAL OF VIROLOGY

Intranasal vaccination with M2e5x virus-like particles induces humoral and cellular immune responses conferring cross-protection against heterosubtypic influenza viruses

(2018) Young-Tae Lee et al.   PLoS One

Circulating T FH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

(2018) Marios Koutsakos et al.   Science Translational Medicine

Protection by universal influenza vaccine is mediated by memory CD4 T cells

(2018) Sophie A. Valkenburg et al.   VACCINE

Responses to live attenuated influenza vaccine in children vaccinated previously with Pandemrix (ASO3 B adjuvanted pandemic A/H1N1pdm09)

(2018) Katja Höschler et al.   VACCINE

Influenza Virus: Dealing with a Drifting and Shifting Pathogen

(2018) Hyunsuh Kim et al.   VIRAL IMMUNOLOGY

Broadly protective anti-hemagglutinin stalk antibodies induced by live attenuated influenza vaccine expressing chimeric hemagglutinin

(2018) Irina Isakova-Sivak et al.   VIROLOGY

How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin

(2018) Michael B. Doud et al.   Nature Communications

Evaluation of animal-to-human and human-to-human transmission of influenza A (H7N9) virus in China, 2013–15

(2018) Victor Virlogeux et al.   Scientific Reports

Adjuvanted influenza vaccines

(2018) John S. Tregoning et al.   Human Vaccines & Immunotherapeutics

Development of a Pan-H1 Influenza Vaccine

(2018) Nicole Darricarrère et al.   JOURNAL OF VIROLOGY

A naturally protective epitope of limited variability as an influenza vaccine target

(2018) Craig P. Thompson et al.   Nature Communications

Kinetic analysis of the influenza A virus HA/NA balance reveals contribution of NA to virus-receptor binding and NA-dependent rolling on receptor-containing surfaces

(2018) Hongbo Guo et al.   PLoS Pathogens

The effect of pre-existing immunity on virus detection and immune responses in a phase II randomized trial of a Russian-backbone live attenuated influenza vaccine in Bangladeshi children

(2018) Elizabeth B Brickley et al.   CLINICAL INFECTIOUS DISEASES

Basics of CD8 T-cell immune responses after influenza infection and vaccination with inactivated or live attenuated influenza vaccine

(2018) Daniil Korenkov et al.   Expert Review of Vaccines

Universal influenza vaccines: from viruses to nanoparticles

(2018) Ye Wang et al.   Expert Review of Vaccines

B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen

(2018) Sheng Hong et al.   IMMUNITY

Immune Correlates of Protection Induced by Virus-Like Particles Containing 2009 H1N1 Pandemic Influenza HA, NA or M1 Proteins

(2018) Eun-Kyung Moon et al.   IMMUNOLOGICAL INVESTIGATIONS

Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem

(2018) Hyon-Xhi Tan et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunodominance and antigenic variation of influenza virus hemagglutinin: implications for design of universal vaccine immunogens

(2018) Seth J Zost et al.   JOURNAL OF INFECTIOUS DISEASES

Broad CD8+ T cell cross-recognition of distinct influenza A strains in humans

(2018) Emma J. Grant et al.   Nature Communications

Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine

(2018) David A. G. Skibinski et al.   Scientific Reports

The way forward: Potentiating protective immunity to novel and pandemic influenza through engagement of memory CD4 T cells

(2018) Andrea J Sant   JOURNAL OF INFECTIOUS DISEASES

The characteristics and antigenic properties of recently emerged subclade 3C.3a and 3C.2a human influenza A(H3N2) viruses passaged in MDCK cells

(2017) Yipu Lin et al.   Influenza and Other Respiratory Viruses

Chimeric Hemagglutinin Constructs Induce Broad Protection against Influenza B Virus Challenge in the Mouse Model

(2017) Megan E. Ermler et al.   JOURNAL OF VIROLOGY

Influenza

(2017) Catharine Paules et al.   LANCET

Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains

(2017) Seth J. Zost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The M2 protein of live, attenuated influenza vaccine encodes a mutation that reduces replication in human nasal epithelial cells

(2017) Nicholas Wohlgemuth et al.   VACCINE

Effectiveness of MF59-adjuvanted seasonal influenza vaccine in the elderly: A systematic review and meta-analysis

(2017) Alexander Domnich et al.   VACCINE

Greater activation of peripheral T follicular helper cells following high dose influenza vaccine in older adults forecasts seroconversion

(2017) Mark A. Pilkinton et al.   VACCINE

Is It Possible to Develop a “Universal” Influenza Virus Vaccine?

(2017) Davide Angeletti et al.   Cold Spring Harbor Perspectives in Biology

Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes

(2017) Murillo Silva et al.   Cell Reports

Nasal IgA Provides Protection against Human Influenza Challenge in Volunteers with Low Serum Influenza Antibody Titre

(2017) Victoria M. W. Gould et al.   Frontiers in Microbiology

CD4 CTL, a Cytotoxic Subset of CD4+ T Cells, Their Differentiation and Function

(2017) Arata Takeuchi et al.   Frontiers in Immunology

A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies

(2017) Raffael Nachbagauer et al.   npj Vaccines

Protective efficacy of influenza group 2 hemagglutinin stem-fragment immunogen vaccines

(2017) Troy C. Sutton et al.   npj Vaccines

Impact of age and pre-existing influenza immune responses in humans receiving split inactivated influenza vaccine on the induction of the breadth of antibodies to influenza A strains

(2017) Ivette A. Nuñez et al.   PLoS One

Antibody Responses to Trivalent Inactivated Influenza Vaccine in Health Care Personnel Previously Vaccinated and Vaccinated for The First Time

(2017) Kuan-Ying A. Huang et al.   Scientific Reports

Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain

(2017) Christopher S. Anderson et al.   Scientific Reports

Comparisons of the Humoral and Cellular Immune Responses Induced by Live Attenuated Influenza Vaccine and Inactivated Influenza Vaccine in Adults

(2016) Daniel F. Hoft et al.   Clinical and Vaccine Immunology

2014–2015 Influenza Vaccine Effectiveness in the United States by Vaccine Type

(2016) Richard K. Zimmerman et al.   CLINICAL INFECTIOUS DISEASES

Influenza immunology evaluation and correlates of protection: a focus on vaccines

(2016) Claudia Maria Trombetta et al.   Expert Review of Vaccines

Influenza Vaccine Effectiveness Against 2009 Pandemic Influenza A(H1N1) Virus Differed by Vaccine Type During 2013–2014 in the United States

(2016) Manjusha Gaglani et al.   JOURNAL OF INFECTIOUS DISEASES

Global epidemiology of avian influenza A H5N1 virus infection in humans, 1997–2015: a systematic review of individual case data

(2016) Shengjie Lai et al.   LANCET INFECTIOUS DISEASES

Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination

(2016) Ali H Ellebedy et al.   NATURE IMMUNOLOGY

Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting

(2016) Katelyn M. Gostic et al.   SCIENCE

Development and approval of live attenuated influenza vaccines based on Russian master donor viruses: Process challenges and success stories

(2016) Larisa Rudenko et al.   VACCINE

Accurate Measurement of the Effects of All Amino-Acid Mutations on Influenza Hemagglutinin

(2016) Michael Doud et al.   Viruses-Basel

CD4 T cell epitope specificity determines follicular versus non-follicular helper differentiation in the polyclonal response to influenza infection or vaccination

(2016) Zackery A. G. Knowlden et al.   Scientific Reports

Multi-epitope Models Explain How Pre-existing Antibodies Affect the Generation of Broadly Protective Responses to Influenza

(2016) Veronika I. Zarnitsyna et al.   PLoS Pathogens

Stalking influenza by vaccination with pre-fusion headless HA mini-stem

(2016) Sophie A. Valkenburg et al.   Scientific Reports

Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens

(2016) Niels Peter H. Knudsen et al.   Scientific Reports

Preserved antiviral adaptive immunity following polyclonal antibody immunotherapy for severe murine influenza infection

(2016) Natalie E. Stevens et al.   Scientific Reports

PB1 as a potential target for increasing the breadth of T-cell mediated immunity to Influenza A

(2016) Ida E. M. Uddbäck et al.   Scientific Reports

Investigating the effect of AS03 adjuvant on the plasma cell repertoire following pH1N1 influenza vaccination

(2016) J. D. Galson et al.   Scientific Reports

Protective Efficacy of the Conserved NP, PB1, and M1 Proteins as Immunogens in DNA- and Vaccinia Virus-Based Universal Influenza A Virus Vaccines in Mice

(2015) Wenling Wang et al.   Clinical and Vaccine Immunology

Abundance and specificity of influenza reactive circulating memory follicular helper and non-follicular helper CD4 T cells in healthy adults

(2015) Scott A. Leddon et al.   IMMUNOLOGY

Kinetics of Hemagglutination-Inhibiting Antibodies Following Maternal Influenza Vaccination Among Mothers With and Those Without HIV Infection and Their Infants

(2015) Marta C. Nunes et al.   JOURNAL OF INFECTIOUS DISEASES

A simple mechanistic explanation for original antigenic sin and its alleviation by adjuvants

(2015) Wilfred Ndifon   Journal of the Royal Society Interface

High Preexisting Serological Antibody Levels Correlate with Diversification of the Influenza Vaccine Response

(2015) Sarah F. Andrews et al.   JOURNAL OF VIROLOGY

Positive Selection in CD8+T-Cell Epitopes of Influenza Virus Nucleoprotein Revealed by a Comparative Analysis of Human and Swine Viral Lineages

(2015) Heather M. Machkovech et al.   JOURNAL OF VIROLOGY

Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands as Influenza Virus Vaccine Adjuvants Induce Rapid, Sustained, and Broadly Protective Responses

(2015) Peter H. Goff et al.   JOURNAL OF VIROLOGY

Masking of antigenic epitopes by antibodies shapes the humoral immune response to influenza

(2015) Veronika I. Zarnitsyna et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

(2015) A. Impagliazzo et al.   SCIENCE

Immune history profoundly affects broadly protective B cell responses to influenza

(2015) Sarah F. Andrews et al.   Science Translational Medicine

Virus-induced preferential antibody gene-usage and its importance in humoral autoimmunity

(2015) Francesca Cappelletti et al.   SEMINARS IN IMMUNOLOGY

Virus-specific T cells as correlate of (cross-)protective immunity against influenza

(2015) Arwen F. Altenburg et al.   VACCINE

An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus

(2015) Louis M. Schwartzman et al.   mBio

Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8+ T cells

(2015) Zhongfang Wang et al.   Nature Communications

Isolation and Characterization of Influenza C Viruses in the Philippines and Japan

(2015) Takashi Odagiri et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Development of live attenuated influenza vaccines against pandemic influenza strains

(2014) Kathleen L Coelingh et al.   Expert Review of Vaccines

CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection

(2014) Brian J. Laidlaw et al.   IMMUNITY

Spanish Flu, Asian Flu, Hong Kong Flu, and Seasonal Influenza in Japan under Social and Demographic Influence: Review and Analysis Using the Two-Population Model

(2014) Hiroshi Yoshikura   JAPANESE JOURNAL OF INFECTIOUS DISEASES

Differences in Antibody Responses Between Trivalent Inactivated Influenza Vaccine and Live Attenuated Influenza Vaccine Correlate With the Kinetics and Magnitude of Interferon Signaling in Children

(2014) Raquel G. Cao et al.   JOURNAL OF INFECTIOUS DISEASES

Seasonal Influenza Can Poise Hosts for CD4 T-Cell Immunity to H7N9 Avian Influenza

(2014) Katherine A. Richards et al.   JOURNAL OF INFECTIOUS DISEASES

Induction of Broadly Reactive Anti-Hemagglutinin Stalk Antibodies by an H5N1 Vaccine in Humans

(2014) R. Nachbagauer et al.   JOURNAL OF VIROLOGY

Low 2012–13 Influenza Vaccine Effectiveness Associated with Mutation in the Egg-Adapted H3N2 Vaccine Strain Not Antigenic Drift in Circulating Viruses

(2014) Danuta M. Skowronski et al.   PLoS One

Antibody landscapes after influenza virus infection or vaccination

(2014) J. M. Fonville et al.   SCIENCE

Technology transfer and scale-up of the Flublok® recombinant hemagglutinin (HA) influenza vaccine manufacturing process

(2014) Barry Buckland et al.   VACCINE

FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability

(2014) Beatriz León et al.   Nature Communications

Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Antibodies against Influenza A Viruses

(2014) Yuval Avnir et al.   PLoS Pathogens

The evolving history of influenza viruses and influenza vaccines

(2013) Claude Hannoun   Expert Review of Vaccines

CD4 T Cell Help Is Limiting and Selective during the Primary B Cell Response to Influenza Virus Infection

(2013) S. Alam et al.   JOURNAL OF VIROLOGY

Heterosubtypic Antiviral Activity of Hemagglutinin-Specific Antibodies Induced by Intranasal Immunization with Inactivated Influenza Viruses in Mice

(2013) Mieko Muramatsu et al.   PLoS One

Vaccine-Induced Anti-HA2 Antibodies Promote Virus Fusion and Enhance Influenza Virus Respiratory Disease

(2013) S. Khurana et al.   Science Translational Medicine

Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase

(2013) Miriam Cohen et al.   Virology Journal

New World Bats Harbor Diverse Influenza A Viruses

(2013) Suxiang Tong et al.   PLoS Pathogens

Comparison of the Effectiveness of Trivalent Inactivated Influenza Vaccine and Live, Attenuated Influenza Vaccine in Preventing Influenza-Like Illness Among US Military Service Members, 2006-2009

(2012) C. J. Phillips et al.   CLINICAL INFECTIOUS DISEASES

CD4+ T-Cell Expansion Predicts Neutralizing Antibody Responses to Monovalent, Inactivated 2009 Pandemic Influenza A(H1N1) Virus Subtype H1N1 Vaccine

(2012) Jennifer L. Nayak et al.   JOURNAL OF INFECTIOUS DISEASES

Influenza Viruses Expressing Chimeric Hemagglutinins: Globular Head and Stalk Domains Derived from Different Subtypes

(2012) R. Hai et al.   JOURNAL OF VIROLOGY

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

(2012) Tom M Wilkinson et al.   NATURE MEDICINE

A VLP Vaccine Induces Broad-Spectrum Cross-Protective Antibody Immunity against H5N1 and H1N1 Subtypes of Influenza A Virus

(2012) Chia-Ying Wu et al.   PLoS One

Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses

(2012) N. Pica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses

(2012) Carolien E. van de Sandt et al.   Viruses-Basel

Virus-like particle (VLP)-based vaccines for pandemic influenza

(2012) Constantino López-Macías   Human Vaccines & Immunotherapeutics

Evidence for Antigenic Seniority in Influenza A (H3N2) Antibody Responses in Southern China

(2012) Justin Lessler et al.   PLoS Pathogens

Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI

(2011) Amaya I. Wolf et al.   JOURNAL OF CLINICAL INVESTIGATION

Live and Inactivated Influenza Vaccines Induce Similar Humoral Responses, but Only Live Vaccines Induce Diverse T-Cell Responses in Young Children

(2011) Daniel F. Hoft et al.   JOURNAL OF INFECTIOUS DISEASES

Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis

(2011) Harish Nair et al.   LANCET

Early Adaptive Humoral Immune Responses and Virus Clearance in Humans Recently Infected with Pandemic 2009 H1N1 Influenza Virus

(2011) Chao Qiu et al.   PLoS One

MF59 Adjuvant Enhances Diversity and Affinity of Antibody-Mediated Immune Response to Pandemic Influenza Vaccines

(2011) S. Khurana et al.   Science Translational Medicine

Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes

(2011) Samuele Calabro et al.   VACCINE

CD8+ T cell immunity to 2009 pandemic and seasonal H1N1 influenza viruses

(2011) Kristin Scheible et al.   VACCINE

Why Do Influenza Virus Subtypes Die Out? A Hypothesis

(2011) P. Palese et al.   mBio

Influenza Virus Evolution, Host Adaptation, and Pandemic Formation

(2010) Jeffery K. Taubenberger et al.   Cell Host & Microbe

Antibody-mediated modulation of immune responses

(2010) Falk Nimmerjahn et al.   IMMUNOLOGICAL REVIEWS

The relative efficacy of trivalent live attenuated and inactivated influenza vaccines in children and adults

(2010) Christopher S. Ambrose et al.   Influenza and Other Respiratory Viruses

Influenza Hemagglutinin and Neuraminidase Membrane Glycoproteins

(2010) Steven J. Gamblin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vaccination inducing broad and improved cross protection against multiple subtypes of influenza A virus

(2010) J.-M. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemagglutinin and neuraminidase matching patterns of two influenza A virus strains related to the 1918 and 2009 global pandemics

(2009) Yonghui Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

H5N1 influenza viruses: outbreaks and biological properties

(2009) Gabriele Neumann et al.   CELL RESEARCH

Memory B cells: Effectors of long-lived immune responses

(2009) Stuart G. Tangye et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Live Attenuated or Inactivated Influenza Vaccines and Medical Encounters for Respiratory Illnesses Among US Military Personnel

(2009) Zhong Wang   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Virus-like particle vaccine activates conventional B2 cells and promotes B cell differentiation to IgG2a producing plasma cells

(2009) Sheng Zhang et al.   MOLECULAR IMMUNOLOGY

Induction of Long-Term Protective Immune Responses by Influenza H5N1 Virus-Like Particles

(2009) Sang-Moo Kang et al.   PLoS One

Kinetics of viral shedding and immune responses in adults following administration of cold-adapted influenza vaccine

(2009) Laura L. Hammitt et al.   VACCINE

Comparison of the trivalent live attenuated vs. inactivated influenza vaccines among U.S. military service members

(2009) Angelia A. Eick et al.   VACCINE

Evaluation of two live attenuated cold-adapted H5N1 influenza virus vaccines in healthy adults

(2009) Ruth A. Karron et al.   VACCINE

Autoimmune response following annual influenza vaccination in 92 apparently healthy adults

(2008) N. Toplak et al.   AUTOIMMUNITY REVIEWS

Finding the real case-fatality rate of H5N1 avian influenza

(2008) F C K Li et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Shedding and immunogenicity of live attenuated influenza vaccine virus in subjects 5–49 years of age

(2008) Stan L. Block et al.   VACCINE