Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes

Inflammatory cytokines expression in Wilson’s disease

(2019) Peng Wu et al.   NEUROLOGICAL SCIENCES

Metabolomics profiles of patients with Wilson disease reveal a distinct metabolic signature

(2019) Gaurav V. Sarode et al.   Metabolomics

An Updated Review of Lysophosphatidylcholine Metabolism in Human Diseases

(2019) Shi-Hui Law et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phenylketonuria in the adult patient

(2019) Leticia Ceberio et al.   Expert Opinion on Orphan Drugs

MetaboAnalystR: an R package for flexible and reproducible analysis of metabolomics data

(2018) Jasmine Chong et al.   BIOINFORMATICS

Apoptosis and non-alcoholic fatty liver diseases

(2018) Tatsuo Kanda et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Studies on diagnostic biomarkers and therapeutic mechanism of Alzheimer's disease through metabolomics and hippocampal proteomics

(2017) Weiwei Lin et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis

(2017) Takahiro Nishio et al.   JOURNAL OF GASTROENTEROLOGY

Neuropsychiatric comorbidities in adults with phenylketonuria: A retrospective cohort study

(2017) Deborah A. Bilder et al.   MOLECULAR GENETICS AND METABOLISM

Role of Nicotinic and Muscarinic Receptors on Synaptic Plasticity and Neurological Diseases

(2016) Marco Fuenzalida et al.   CURRENT PHARMACEUTICAL DESIGN

Acetylcholine induces fibrogenic effects via M2/M3 acetylcholine receptors in non-alcoholic steatohepatitis and in primary human hepatic stellate cells

(2016) Maelle L Morgan et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Neuronal histamine and cognitive symptoms in Alzheimer's disease

(2016) Armin Zlomuzica et al.   NEUROPHARMACOLOGY

Plasma phospholipids and fatty acid composition differ between liver biopsy-proven nonalcoholic fatty liver disease and healthy subjects

(2016) D W L Ma et al.   Nutrition & Diabetes

Division of labour: how does folate metabolism partition between one-carbon metabolism and amino acid oxidation?

(2015) M. E. Brosnan et al.   BIOCHEMICAL JOURNAL

NADPH oxidase 4 regulates homocysteine metabolism and protects against acetaminophen-induced liver damage in mice

(2015) Thomas V.A. Murray et al.   FREE RADICAL BIOLOGY AND MEDICINE

Wilson’s Disease: A Comprehensive Review of the Molecular Mechanisms

(2015) Fei Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wilson's disease and other neurological copper disorders

(2015) Oliver Bandmann et al.   LANCET NEUROLOGY

A Study on Apoptosis and Anti-apoptotic Status in Wilson Disease

(2015) J. Kalita et al.   MOLECULAR NEUROBIOLOGY

MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis

(2015) Hiroshi Tsugawa et al.   NATURE METHODS

Pathological mitochondrial copper overload in livers of Wilson's disease patients and related animal models

(2014) Hans Zischka et al.   Annals of the New York Academy of Sciences

Modifying factors and phenotypic diversity in Wilson's disease

(2014) Svetlana Lutsenko   Annals of the New York Academy of Sciences

Plasma acylcarnitines inadequately reflect tissue acylcarnitine metabolism

(2014) Marieke G. Schooneman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

Human serum acylcarnitine profiles in different glucose tolerance states

(2014) Xiuying Zhang et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Characterization of Timed Changes in Hepatic Copper Concentrations, Methionine Metabolism, Gene Expression, and Global DNA Methylation in the Jackson Toxic Milk Mouse Model of Wilson Disease

(2014) Anh Le et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A study of oxidative stress, cytokines and glutamate in Wilson disease and their asymptomatic siblings

(2014) Jayantee Kalita et al.   JOURNAL OF NEUROIMMUNOLOGY

Sphingosine Kinase 1 and Sphingosine-1-Phosphate in Oxidative Stress Evoked by 1-Methyl-4-Phenylpyridinium (MPP+) in Human Dopaminergic Neuronal Cells

(2014) Joanna Pyszko et al.   MOLECULAR NEUROBIOLOGY

Plasma phospholipids identify antecedent memory impairment in older adults

(2014) Mark Mapstone et al.   NATURE MEDICINE

Alterations of Plasma Lysophosphatidylcholine Species in Obesity and Weight Loss

(2014) Susanne Heimerl et al.   PLoS One

Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase byS-adenosylmethionine

(2014) June Ereño-Orbea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonalcoholic fatty liver disease is associated with lower hepatic and erythrocyte ratios of phosphatidylcholine to phosphatidylethanolamine

(2013) Bianca M. Arendt et al.   Applied Physiology Nutrition and Metabolism

Peroxisomes contribute to the acylcarnitine production when the carnitine shuttle is deficient

(2013) Sara Violante et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease

(2013) Luke Whiley et al.   NEUROBIOLOGY OF AGING

Lysophosphatidylcholine Triggers TLR2- and TLR4-Mediated Signaling Pathways but Counteracts LPS-Induced NO Synthesis in Peritoneal Macrophages by Inhibiting NF-κB Translocation and MAPK/ERK Phosphorylation

(2013) Alan Brito Carneiro et al.   PLoS One

Biological functions of sphingomyelins

(2013) J. Peter Slotte   PROGRESS IN LIPID RESEARCH

Novel bioactive glycerol-based lysophospholipids: New data – New insight into their function

(2012) Anna Grzelczyk et al.   BIOCHIMIE

Wilson's disease: Changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease

(2012) Valentina Medici et al.   HEPATOLOGY

Prevention of 1-palmitoyl lysophosphatidylcholine-induced inflammation by polyunsaturated acyl lysophosphatidylcholine

(2012) Nguyen Dang Hung et al.   INFLAMMATION RESEARCH

Plasma phosphatidylcholine and sphingomyelin concentrations are associated with depression and anxiety symptoms in a Dutch family-based lipidomics study

(2012) Ayşe Demirkan et al.   JOURNAL OF PSYCHIATRIC RESEARCH

A systems approach implicates nuclear receptor targeting in the Atp7b−/− mouse model of Wilson's disease

(2012) Phillip A. Wilmarth et al.   Metallomics

Sphingosine Kinase 1 Deficiency Exacerbates LPS-Induced Neuroinflammation

(2012) Natalia M. Grin’kina et al.   PLoS One

Plasma Lysophosphatidylcholine Levels Are Reduced in Obesity and Type 2 Diabetes

(2012) Melissa N. Barber et al.   PLoS One

Phosphatidylcholine biosynthesis and lipoprotein metabolism

(2011) Laura K. Cole et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans

(2011) Amy K. Walker et al.   CELL

Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression

(2011) Karen D. Corbin et al.   CURRENT OPINION IN GASTROENTEROLOGY

Genetic variability in the methylenetetrahydrofolate reductase gene (MTHFR) affects clinical expression of Wilson’s disease

(2011) Grażyna Gromadzka et al.   JOURNAL OF HEPATOLOGY

Neutral sphingomyelinase activation precedes NADPH oxidase-dependent damage in neurons exposed to the proinflammatory cytokine tumor necrosis factor-α

(2011) Brian M. Barth et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The monoamine neurotransmitter disorders: an expanding range of neurological syndromes

(2011) Manju A Kurian et al.   LANCET NEUROLOGY

Alterations of lipid metabolism in Wilson disease

(2011) Jessica Seessle et al.   Lipids in Health and Disease

Postprandial changes in plasma acylcarnitine concentrations as markers of fatty acid flux in overweight and obesity

(2011) Maria A. Ramos-Roman et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst

(2011) Jianguo Xia et al.   Nature Protocols

Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis

(2010) Norman J. Haughey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mechanisms for anti-inflammatory effects of 1-[15(S)-hydroxyeicosapentaenoyl] lysophosphatidylcholine, administered intraperitoneally, in zymosan A-induced peritonitis

(2010) Nguyen Dang Hung et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identifying Health Impacts of Exposure to Copper Using Transcriptomics and Metabolomics in a Fish Model

(2009) Eduarda M. Santos et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Proteomic analysis of human bile and potential applications for cancer diagnosis

(2009) Annarita Farina et al.   Expert Review of Proteomics

Acylcarnitine profile analysis

(2009) Piero Rinaldo et al.   GENETICS IN MEDICINE

Bile acid transporters

(2009) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

Plasma Acylcarnitine Profiles Suggest Incomplete Long-Chain Fatty Acid β-Oxidation and Altered Tricarboxylic Acid Cycle Activity in Type 2 Diabetic African-American Women

(2009) Sean H. Adams et al.   JOURNAL OF NUTRITION

Comparison of Lipid and Fatty Acid Composition of the Liver, Subcutaneous and Intra-abdominal Adipose Tissue, and Serum

(2009) Anna Kotronen et al.   Obesity

Early effects of copper accumulation on methionine metabolism

(2008) M. Delgado et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Muscle acylcarnitines during short-term fasting in lean healthy men

(2008) Maarten R. Soeters et al.   CLINICAL SCIENCE

Thematic Review Series: Sphingolipids.Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling,

(2008) Deborah A. Lebman et al.   JOURNAL OF LIPID RESEARCH

Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics

(2008) Vitali Matyash et al.   JOURNAL OF LIPID RESEARCH

Deregulation of sphingolipid metabolism in Alzheimer's disease

(2008) Xingxuan He et al.   NEUROBIOLOGY OF AGING

Histamine in the Nervous System

(2008) Helmut L. Haas et al.   PHYSIOLOGICAL REVIEWS

Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies

(2008) Laura K. Schnackenberg et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY