RAF Kinase Inhibitor Protein in Myeloid Leukemogenesis

New insights into hematopoietic differentiation landscapes from single-cell RNA sequencing

(2019) Sam Watcham et al.   BLOOD

Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis

(2019) Veronica Caraffini et al.   HAEMATOLOGICA

The Austrian biodatabase for chronic myelomonocytic leukemia (ABCMML)

(2019) Klaus Geissler et al.   WIENER KLINISCHE WOCHENSCHRIFT

Chronic myelomonocytic leukemia: 2018 update on diagnosis, risk stratification and management

(2018) Mrinal M. Patnaik et al.   AMERICAN JOURNAL OF HEMATOLOGY

Loss of RKIP is a frequent event in myeloid sarcoma and promotes leukemic tissue infiltration

(2018) Veronica Caraffini et al.   BLOOD

Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

(2018) Hiroyoshi Kunimoto et al.   CANCER CELL

Inhibition of the Raf-1 kinase inhibitory protein (RKIP) by locostatin induces cell death and reduces the CXCR4-mediated migration of chronic lymphocytic leukemia cells

(2018) Kyle Crassini et al.   LEUKEMIA & LYMPHOMA

RKIP: A Key Regulator in Tumor Metastasis Initiation and Resistance to Apoptosis: Therapeutic Targeting and Impact

(2018) Apostolos Zaravinos et al.   Cancers

Clinical implications of subclonal TP53 mutations in acute myeloid leukemia

(2018) Katharina T. Prochazka et al.   HAEMATOLOGICA

Azacitidine for Front-Line Therapy of Patients with AML: Reproducible Efficacy Established by Direct Comparison of International Phase 3 Trial Data with Registry Data from the Austrian Azacitidine Registry of the AGMT Study Group

(2017) Lisa Pleyer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Promoter methylation and expression of Raf kinase inhibitory protein in esophageal squamous cell carcinoma

(2017) Hong Wei et al.   Oncology Letters

Urinary RKIP/p-RKIP is a potential diagnostic and prognostic marker of clear cell renal cell carcinoma

(2017) Massimo Papale et al.   Oncotarget

Acute myeloid leukemia with TP53 germ line mutations

(2016) A. Zebisch et al.   BLOOD

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

(2016) Hartmut Döhner et al.   BLOOD

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

(2016) D. A. Arber et al.   BLOOD

Increased Expression of miR-23a Mediates a Loss of Expression in the RAF Kinase Inhibitor Protein RKIP

(2016) S. Hatzl et al.   CANCER RESEARCH

Azacitidine front-line in 339 patients with myelodysplastic syndromes and acute myeloid leukaemia: comparison of French-American-British and World Health Organization classifications

(2016) Lisa Pleyer et al.   Journal of Hematology & Oncology

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cytogenetic and molecular abnormalities in chronic myelomonocytic leukemia

(2016) M M Patnaik et al.   Blood Cancer Journal

International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts

(2015) H. Dombret et al.   BLOOD

MicroRNAs in cancer: from developmental genes in worms to their clinical application in patients

(2015) M Pichler et al.   BRITISH JOURNAL OF CANCER

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biology and Clinical Relevance of Acute Myeloid Leukemia Stem Cells

(2015) Andreas Reinisch et al.   SEMINARS IN HEMATOLOGY

MicroRNA Processing and Human Cancer

(2015) Masahisa Ohtsuka et al.   Journal of Clinical Medicine

miR-27a regulates cisplatin resistance and metastasis by targeting RKIP in human lung adenocarcinoma cells

(2014) Jipeng Li et al.   Molecular Cancer

The molecular basis of myeloid malignancies

(2014) Toshio KITAMURA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Raf kinase inhibitor protein (RKIP) deficiency decreases latency of tumorigenesis and increases metastasis in a murine genetic model of prostate cancer

(2014) June Escara-Wilke et al.   PROSTATE

Expression of RKIP in chronic myelogenous leukemia K562 cell and inhibits cell proliferation by regulating the ERK/MAPK pathway

(2014) Bin Li et al.   TUMOR BIOLOGY

Promoter methylation of Raf kinase inhibitory protein: A significant prognostic indicator for patients with gastric adenocarcinoma

(2014) DONG-XIA LI et al.   Experimental and Therapeutic Medicine

RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients

(2013) Sam Cross-Knorr et al.   BMC CANCER

Is acute myeloid leukemia a liquid tumor?

(2013) Maro Ohanian et al.   INTERNATIONAL JOURNAL OF CANCER

RKIP: Much more than Raf Kinase inhibitory protein

(2013) Fahd Al-Mulla et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MicroRNA-224 targets RKIP to control cell invasion and expression of metastasis genes in human breast cancer cells

(2012) Lin Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Raf kinase inhibitor protein (RKIP) in cancer

(2012) June Escara-Wilke et al.   CANCER AND METASTASIS REVIEWS

Decreased Expression and Aberrant Methylation of Raf Kinase Inhibitory Protein Gene in Esophageal Squamous Cell Carcinoma

(2012) Wei Guo et al.   CANCER INVESTIGATION

Incidence, survival and prevalence of myeloid malignancies in Europe

(2012) O. Visser et al.   EUROPEAN JOURNAL OF CANCER

Mutations inDNMT3A and loss of RKIP are independent events in acute monocytic leukemia

(2012) I. Fried et al.   HAEMATOLOGICA

Multicenter, Randomized, Open-Label, Phase III Trial of Decitabine Versus Patient Choice, With Physician Advice, of Either Supportive Care or Low-Dose Cytarabine for the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia

(2012) Hagop M. Kantarjian et al.   JOURNAL OF CLINICAL ONCOLOGY

Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemia

(2012) A Zebisch et al.   LEUKEMIA

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

(2012) Li Ding et al.   NATURE

Clonal evolution of acute leukemia genomes

(2012) M Jan et al.   ONCOGENE

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

(2011) Kelly Moran-Crusio et al.   CANCER CELL

Raf Kinase Inhibitor Protein RKIP Enhances Signaling by Glycogen Synthase Kinase-3β

(2011) Fahd Al-Mulla et al.   CANCER RESEARCH

Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells

(2011) Takaaki Konuma et al.   EXPERIMENTAL HEMATOLOGY

State of the art in myeloid sarcoma

(2011) J. M. KLCO et al.   International Journal of Laboratory Hematology

Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia cells

(2010) Xuening Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

(2010) Y. Wang et al.   SCIENCE

The role of microRNA in human leukemia: a review

(2009) S Yendamuri et al.   LEUKEMIA

Loss of RAF kinase inhibitor protein is a somatic event in the pathogenesis of therapy-related acute myeloid leukemias with C-RAF germline mutations

(2009) A Zebisch et al.   LEUKEMIA

MicroRNAs

(2008) Muller Fabbri et al.   CANCER JOURNAL

Akt regulates vitamin D3-induced leukemia cell functional differentiation via Raf/MEK/ERK MAPK signaling

(2008) Jianrong Wang et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Patients With Acute Myeloid Leukemia andRASMutations Benefit Most From Postremission High-Dose Cytarabine: A Cancer and Leukemia Group B Study

(2008) Andreas Neubauer et al.   JOURNAL OF CLINICAL ONCOLOGY