MicroRNA Processing and Human Cancer

Recurrent DGCR8, DROSHA, and SIX Homeodomain Mutations in Favorable Histology Wilms Tumors

(2015) Amy L. Walz et al.   CANCER CELL

Mutations in the SIX1/2 Pathway and the DROSHA/DGCR8 miRNA Microprocessor Complex Underlie High-Risk Blastemal Type Wilms Tumors

(2015) Jenny Wegert et al.   CANCER CELL

N6-methyladenosine marks primary microRNAs for processing

(2015) Claudio R. Alarcón et al.   NATURE

eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference

(2015) Tingfang Yi et al.   Nature Communications

Dissecting the roles of TRBP and PACT in double-stranded RNA recognition and processing of noncoding RNAs

(2015) Alex Heyam et al.   Wiley Interdisciplinary Reviews-RNA

Rare Drosha Splice Variants Are Deficient in MicroRNA Processing but Do Not Affect General MicroRNA Expression in Cancer Cells

(2015) Stefanie E. Grund et al.   NEOPLASIA

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

(2014) Sonia A. Melo et al.   CANCER CELL

MicroRNA let-7 downregulates STAT3 phosphorylation in pancreatic cancer cells by increasing SOCS3 expression

(2014) Kripa Patel et al.   CANCER LETTERS

Lin28 sustains early renal progenitors and induces Wilms tumor

(2014) A. Urbach et al.   GENES & DEVELOPMENT

The RNA-Binding Protein DDX1 Promotes Primary MicroRNA Maturation and Inhibits Ovarian Tumor Progression

(2014) Cecil Han et al.   Cell Reports

Integrated Analyses Identify a Master MicroRNA Regulatory Network for the Mesenchymal Subtype in Serous Ovarian Cancer

(2013) Da Yang et al.   CANCER CELL

DICER1, DROSHA and miRNAs in patients with non-small cell lung cancer: implications for outcomes and histologic classification

(2013) C. Vanesa Díaz-García et al.   CARCINOGENESIS

An essential microRNA maturing microprocessor complex component DGCR8 is up-regulated in colorectal carcinomas

(2013) Bora Kim et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Knockdown of β-catenin with Dicer-Substrate siRNAs Reduces Liver Tumor Burden In vivo

(2013) Henryk Dudek et al.   MOLECULAR THERAPY

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2

(2013) Jia Shen et al.   NATURE

MicroRNAs and other non-coding RNAs as targets for anticancer drug development

(2013) Hui Ling et al.   NATURE REVIEWS DRUG DISCOVERY

Treatment of HCV Infection by Targeting MicroRNA

(2013) Harry L.A. Janssen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing

(2013) Ho Young Lee et al.   NUCLEIC ACIDS RESEARCH

MiR-138 downregulates miRNA processing in HeLa cells by targeting RMND5A and decreasing Exportin-5 stability

(2013) Jie Li et al.   NUCLEIC ACIDS RESEARCH

miRBase: annotating high confidence microRNAs using deep sequencing data

(2013) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

DNA-Damage-Induced Nuclear Export of Precursor MicroRNAs Is Regulated by the ATM-AKT Pathway

(2013) Guohui Wan et al.   Cell Reports

A TARBP2-Dependent miRNA Expression Profile Underlies Cancer Stem Cell Properties and Provides Candidate Therapeutic Reagents in Ewing Sarcoma

(2012) Claudio De Vito et al.   CANCER CELL

Downregulated Dicer expression predicts poor prognosis in chronic lymphocytic leukemia

(2012) Dan-Xia Zhu et al.   CANCER SCIENCE

A comprehensive analysis of precursor microRNA cleavage by human Dicer

(2012) Y. Feng et al.   RNA

MicroRNA-138 suppresses epithelial–mesenchymal transition in squamous cell carcinoma cell lines

(2011) Xiqiang Liu et al.   BIOCHEMICAL JOURNAL

Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients

(2011) Johannes Stratmann et al.   BMC CANCER

A precursor microRNA in a cancer cell nucleus

(2011) Sonia A. Melo et al.   CELL CYCLE

Overexpression of Dicer predicts poor survival in colorectal cancer

(2011) C. Faber et al.   EUROPEAN JOURNAL OF CANCER

RNA helicases p68 and p72: multifunctional proteins with important implications for cancer development

(2011) Frances V Fuller-Pace et al.   Future Oncology

Hypoxia Potentiates MicroRNA-Mediated Gene Silencing through Posttranslational Modification of Argonaute2

(2011) C. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

The ATM Kinase Induces MicroRNA Biogenesis in the DNA Damage Response

(2011) Xinna Zhang et al.   MOLECULAR CELL

Alternative miRNA Biogenesis Pathways and the Interpretation of Core miRNA Pathway Mutants

(2011) Jr-Shiuan Yang et al.   MOLECULAR CELL

Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex

(2011) E. S. Machlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Argonaute proteins regulate microRNA stability: Increased microRNA abundance by Argonaute proteins is due to microRNA stabilization

(2011) Julia Winter et al.   RNA Biology

A Genetic Defect in Exportin-5 Traps Precursor MicroRNAs in the Nucleus of Cancer Cells

(2010) Sonia A. Melo et al.   CANCER CELL

microRNA Signature and Expression of Dicer and Drosha Can Predict Prognosis and Delineate Risk Groups in Neuroblastoma

(2010) R.-J. Lin et al.   CANCER RESEARCH

Somatic mutations and losses of expression of microRNA regulation-related genes AGO2 and TNRC6A in gastric and colorectal cancers

(2010) Min S Kim et al.   JOURNAL OF PATHOLOGY

Biological functions of microRNAs: a review

(2010) Yong Huang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha

(2010) Brandi N. Davis et al.   MOLECULAR CELL

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

(2010) Filipp Frank et al.   NATURE

The widespread regulation of microRNA biogenesis, function and decay

(2010) Jacek Krol et al.   NATURE REVIEWS GENETICS

Modulation of microRNA processing by p53

(2009) Hiroshi I. Suzuki et al.   NATURE

Lin28 promotes transformation and is associated with advanced human malignancies

(2009) Srinivas R Viswanathan et al.   NATURE GENETICS

A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function

(2009) Sonia A Melo et al.   NATURE GENETICS

Small silencing RNAs: an expanding universe

(2009) Megha Ghildiyal et al.   NATURE REVIEWS GENETICS

Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding

(2009) Irene Díaz-Moreno et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DICER1 Mutations in Familial Pleuropulmonary Blastoma

(2009) D. A. Hill et al.   SCIENCE

MicroRNA-10a Binds the 5′UTR of Ribosomal Protein mRNAs and Enhances Their Translation

(2008) Ulf Andersson Ørom et al.   MOLECULAR CELL

Central Delivery of Dicer-substrate siRNA: A Direct Application for Pain Research

(2008) Louis Doré-Savard et al.   MOLECULAR THERAPY

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

SMAD proteins control DROSHA-mediated microRNA maturation

(2008) Brandi N. Davis et al.   NATURE

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS

Dicer, Drosha, and Outcomes in Patients with Ovarian Cancer

(2008) William M. Merritt et al.   NEW ENGLAND JOURNAL OF MEDICINE

The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis

(2008) B. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Marital resemblance for obsessive–compulsive, anxious and depressive symptoms in a population-based sample

(2008) D. S. van Grootheest et al.   PSYCHOLOGICAL MEDICINE

Argonaute proteins: key players in RNA silencing

(2007) Gyorgy Hutvagner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY