Article
Immunology
Qiang Qin, Huan Liu, Jia'nan Shou, Yu Jiang, Hong Yu, Xiaojian Wang
Summary: Research shows that RKIP negatively regulates the activation of the NLRP1, NLRP3, and NLRC4 inflammasomes, impacting the pathogenesis of various inflammatory diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Microbiology
M. A. Abo-Kadoum, Mohammed Assad, Yongdong Dai, Nzungize Lambert, Ulrich Aymard Ekomi Moure, Adel Eltoukhy, Stech A. E. Nzaou, Asmaa Moaaz, Jianping Xie
Summary: The study demonstrated the role of PEBP protein Rv2140c in regulating phosphorylation of mycobacterial arabinogalactan biosynthesis proteins, impacting metabolism, cellular processes, signaling, and cell wall synthesis in the bacteria M. smegmatis.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Yichi Xu, Xin Chen, Shuya Pan, Zhi-wei Wang, Xueqiong Zhu
Summary: TM7SF2 plays a crucial role in promoting cell proliferation and metastasis, inhibiting cell apoptosis, preventing G0/G1 phase arrest, and participating in tumorigenesis and progression through the C-Raf/ERK pathway in cervical cancer. The overexpression of TM7SF2 enhances xenograft tumor growth in vivo, indicating its potential as a therapeutic target for cervical cancer treatment in the future.
CELL DEATH DISCOVERY
(2021)
Article
Oncology
Silvia Vivarelli, Luca Falzone, Caterina Maria Grillo, Benjamin Bonavida, Claudia Crimi, Ignazio La Mantia, Massimo Libra
Summary: Lung cancer is a global threat with high mortality rates, and there is an urgent need for reliable predictive biomarkers and therapeutic targets. The transcription factor YY1 and its target RKIP show potential as biomarkers and therapeutic targets in lung cancer, with computational analysis suggesting predictive diagnostic and prognostic roles. Further studies are needed to validate these findings.
Article
Chemistry, Multidisciplinary
Wei Yu, Min Liao, Yang Chen, Rui Xue, Xiao-Meng Shi, Dan Liu, Fang-Fang Zhuo, Hui Tang, Zhi-Yuan Lu, Peng-Fei Tu, Bo Han, Xin Jia, Ke-Wu Zeng
Summary: This study identified phosphatidyl-ethanolamine binding protein1 (PEBP1) as a cellular target of ethyl gallate (EG), a natural small molecule for ulcerative colitis (UC) treatment. EG inhibited the phosphorylation of PEBP1 and enhanced PEBP1-Raf-1 interaction to block the NF-kappa B inflammatory pathway in macrophages. It was also found that PEBP1 serves as an essential anti-inflammation mechanism in UC therapy.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Medicinal
Seyed-Omar Zaraei, Nour N. Al-Ach, Hanan S. Anbar, Randa El-Gamal, Hamadeh Tarazi, Rimas T. Tokatly, Rawan R. Kalla, Mouna A. Munther, Marwa M. Wahba, Aya M. Alshihabi, Mahmoud K. Shehata, Rawan M. Sbenati, Afnan I. Shahin, Raafat El-Awady, Taleb H. Al-Tel, Mohammed I. El-Gamal
Summary: This article presents the design, synthesis, and biological screening results of a new series of diarylurea and diarylamide derivatives with a quinoline core armed with dimethylamino or morpholino side chains. The compounds showed broad-spectrum antiproliferative activity against a panel of 60 cancer cell lines, with three of them demonstrating higher potency than the reference drug, sorafenib. The compounds also exhibited high selectivity for C-RAF kinase, making them potential inhibitors for this molecular target.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Shuai Zhang, Xiaobin An, Siyu Huang, Lu Zeng, Yi Xu, Dan Su, Yang Qu, Xin Tang, Jing Ma, Junkai Yang, Jing Ai
Summary: Estrogen deficiency induces cognitive impairment, with miR-23a-3p playing a role in hippocampal function through the AhR/miR-23a-3p/PKCa axis.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Multidisciplinary Sciences
Jiyoung Lee, Cristina Olivieri, Colin Ong, Larry R. Masterson, Suzana Gomes, Bok-Soon Lee, Florian Schaefer, Kristina Lorenz, Gianluigi Veglia, Marsha Rich Rosner
Summary: Phosphorylation of RKIP at S153 by PKC triggers a switch from inhibition of Raf to inhibition of GRK2, enhancing signaling by beta-AR that activates PKA. PKA-phosphorylated RKIP at S51 promotes beta-AR-activated PKA signaling by triggering feedback activation of PKA. This allosteric regulatory mechanism may have therapeutic potential for regulating PKA signaling in disease states.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Jinxin Li, Huimin Sun, Meiling Fu, Zeyuan Zheng, Chunlan Xu, Kunao Yang, Yankuo Liu, Zuodong Xuan, Yang Bai, Jianzhong Zheng, Yue Zhao, Zhiyuan Shi, Chen Shao
Summary: This study demonstrates that high expression of TOPK in RCC promotes PD-L1 expression by activating ERK2 and TGF-beta/Smad pathways. TOPK is also shown to inhibit CD8(+) T cell infiltration and function, promoting immune escape in RCC. Inhibition of TOPK enhances CD8(+) T cell infiltration, activation, anti-PD-L1 therapeutic efficacy, and synergistically enhances anti-RCC immune response.
Article
Biotechnology & Applied Microbiology
Xi Zhou, Xia Zhao, ZhouYi Wu, Yan Ma, Heng Li
Summary: The long non-coding RNA FLVCR1-AS1 plays an important role in cervical cancer by competitively inhibiting the expression of microRNA-23a-5p and regulating the expression of SLC7A11 gene, thereby affecting the proliferation, migration, invasion, and apoptosis of cervical cancer cells.
Article
Oncology
Yuanjun Lu, Yau-Tuen Chan, Hor-Yue Tan, Cheng Zhang, Wei Guo, Yu Xu, Rakesh Sharma, Zhe-Sheng Chen, Yi-Chao Zheng, Ning Wang, Yibin Feng
Summary: Our study reveals that the ETS1/miR-23a-3p/ACSL4 axis contributes to sorafenib resistance in HCC by regulating ferroptosis. This suggests that miR-23a-3p could be a potential target for improving sorafenib responsiveness in HCC patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Immunology
Ling Yu, Huiqian Yu, Shuai Zhang, Yanzhao Hao, Shoumin Zhang
Summary: Alopecia universalis is an autoimmune disorder characterized by non-scarring hair loss in the body, which negatively impacts patient prognosis. CD8+ T cells are believed to cause autoimmune attacks on hair follicles, leading to the collapse of hair follicle immune privilege. Janus kinase inhibitors have the potential to inhibit IFN-gamma and may be a promising treatment option for AU patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Pablo Fernandez-Tussy, Ruben Rodriguez-Agudo, David Fernandez-Ramos, Lucia Barbier-Torres, Imanol Zubiete-Franco, Sergio Lopez de Davalillo, Elisa Herraez, Naroa Goikoetxea-Usandizaga, Sofia Lachiondo-Ortega, Jorge Simon, Fernando Lopitz-Otsoa, Virginia Gutierrez-de Juan, Misti V. McCain, Maria J. Perugorria, Jon Mabe, Nicolas Navasa, Cecilia M. P. Rodrigues, Isabel Fabregat, Loreto Boix, Victor Sapena, Juan Anguita, Shelly C. Lu, Jose M. Mato, Jesus M. Banales, Erica Villa, Helen L. Reeves, Jordi Bruix, Maria Reig, Jose J. G. Marin, Teresa C. Delgado, Maria L. Martinez-Chantar
Summary: miR-518d-5p modulates sorafenib resistance in HCC through inhibition of c-Jun/PUMA-induced apoptosis, and circulating miR-518d-5p emerges as a potential biomarker for lack of response to sorafenib.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Christian E. Argueta, Christopher Figy, Sawssen Bouali, Anna Guo, Kam C. Yeung, Gabriel Fenteany
Summary: Raf kinase inhibitor protein (RKIP) primarily localizes in the nucleus and contains a putative bipartite nuclear localization signal (NLS) rich in arginine and lysine residues. Deletion or point mutations in the putative NLS result in decreased nuclear localization of RKIP. RKIP interacts with importin alpha, suggesting importin-mediated active nuclear translocation. The presence of the putative NLS is important for RKIP's role in mitotic checkpoint regulation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Immunology
Austin Boucher, Nathan Klopfenstein, William Morgan Hallas, Jennifer Skibbe, Andrew Appert, Seok Hee Jang, Kirthi Pulakanti, Sridhar Rao, Karen D. Cowden Dahl, Richard Dahl
Summary: The miRNA cluster mirn23a regulates macrophage polarization, with mirn23a(-/-) mice showing worse outcomes in tumor growth experiments, indicating a critical role in tumor immunity. Manipulation of mirn23a miRNA can be used to direct macrophage polarization for desired immune responses.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Hematology
Sayantanee Dutta, Jennifer Moritz, Gudrun Pregartner, Gerhard G. Thallinger, Ilona Brandstaetter, Karin Lind, Simin Rezania, Freya Lyssy, Andreas Reinisch, Armin Zebisch, Andrea Berghold, Albert Woelfler, Heinz Sill
Summary: The study found TP53 aberrations to be common in AML and MDS patients, with similar clinical and cytogenetic characteristics, but higher overall survival in MDS patients compared to AML patients. High transformation rate of TP53 aberrant MDS reduces survival probability for patients.
ANNALS OF HEMATOLOGY
(2022)
Editorial Material
Urology & Nephrology
Andrea Katharina Lindner, Martin Pichler, Martin Thurnher, Renate Pichler
Article
Biochemistry & Molecular Biology
Alexander Michael Grandits, Sophie Bromberger, Gerwin Heller, Barbara Andrea Reinoehl, Erwin Tomasich, Klaudia Schossleitner, Anna Sophie Berghoff, Thorsten Fuereder, Rotraud Wieser
Summary: Head and neck squamous cell carcinoma (HNSCC) is a frequent malignancy with a poor prognosis. EVI1, a novel oncogene, promotes cellular proliferation and invasiveness in HNSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jelena Krstic, Isabel Reinisch, Katharina Schindlmaier, Markus Galhuber, Zina Riahi, Natascha Berger, Nadja Kupper, Elisabeth Moyschewitz, Martina Auer, Helene Michenthaler, Christoph Noessing, Maria R. Depaoli, Jeta Ramadani-Muja, Sinem Usluer, Sarah Stryeck, Martin Pichler, Beate Rinner, Alexander J. A. Deutsch, Andreas Reinisch, Tobias Madl, Riccardo Zenezini Chiozzi, Albert J. R. Heck, Meritxell Huch, Roland Malli, Andreas Prokesch
Summary: Fasting improves the efficacy of sorafenib and sensitizes sorafenib-resistant HCC by preventing the Warburg shift through reduction in glucose and AKT/mTOR signaling. p53 is necessary for the sorafenib-sensitizing effect of fasting.
Article
Hematology
Klaus Geissler, Eva Jaeger, Agnes Barna, Michael Gurbisz, Renate Marschon, Temeida Graf, Thomas Noesslinger, Michael Pfeilstoecker, Sigrid Machherndl-Spandl, Reinhard Stauder, Armin Zebisch, Heinz Sill, Leopold Oehler, Rajko Kusec, Gregor Hoermann, Peter Valent
Summary: The study demonstrates validation of a multistep pathogenesis model in CMML patients, with worse prognosis in patients with TET2/SRSF2/NRAS complex mutations and higher risk of AML transformation.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2022)
Article
Oncology
Michael Leisch, Michael Pfeilstoecker, Reinhard Stauder, Sonja Heibl, Heinz Sill, Michael Girschikofsky, Margarete Stampfl-Mattersberger, Christoph Tinchon, Bernd Hartmann, Andreas Petzer, Martin Schreder, David Kiesl, Sonia Vallet, Alexander Egle, Thomas Melchardt, Gudrun Piringer, Armin Zebisch, Sigrid Machherndl-Spandl, Dominik Wolf, Felix Keil, Manuel Drost, Richard Greil, Lisa Pleyer
Summary: Azacitidine is the only drug proven to prolong overall survival and is recommended for patients with certain types of leukemia. Adverse events during treatment with azacitidine were analyzed, and it was found that hematologic adverse events occurred at a similar rate compared to clinical trials, but gastrointestinal toxicities were less commonly reported.
Article
Biochemistry & Molecular Biology
Barbara Uhl, Katharina T. Prochazka, Katrin Pansy, Kerstin Wenzl, Johanna Strobl, Claudia Baumgartner, Marta M. Szmyra, James E. Waha, Axel Wolf, Peter Tomazic, Elisabeth Steinbauer, Maria Steinwender, Sabine Friedl, Marc Weniger, Ralf Kueppers, Martin Pichler, Hildegard T. Greinix, Georg Stary, Alan G. Ramsay, Benedetta Apollonio, Julia Feichtinger, Christine Beham-Schmid, Peter Neumeister, Alexander J. Deutsch
Summary: Chemokine receptors and their ligands play an important role in the development of DLBCL, follicular lymphoma, and RS. This study found that the expression profiles of chemokine receptors in de novo DLBCL and tFL were significantly different from that of GC-B and RS. High expression of CCR7 was associated with poor overall survival in patients with de novo DLBCL and tFL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Oncology
Markus G. Seidel, Luka Brcic, Gerald Hoefler, Caroline Hutter, Milen Minkov, Laura Sophie Steffen, Armin Zebisch, Martin Benesch
PEDIATRIC BLOOD & CANCER
(2023)
Letter
Hematology
Noemi Meszaros, Karin Lind, Robert Sehlke, Bojan Vilagos, Nikolaus Krall, Gregory I. Vladimer, Heinz Sill
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Cell Biology
Joerg Lindenmann, Melanie Fediuk, Nicole Fink-Neuboeck, Iurii Mykoliuk, Elisabeth Taucher, Martin Pichler, Josef Smolle, Freyja Maria Smolle-Juettner
Summary: Chronic obstructive pulmonary disease (COPD) is a risk factor for the development of lung cancer and has prognostic impact after surgery for non-small cell lung cancer (NSCLC). This study aimed to investigate the impact of COPD and postoperative mucostasis on long-term survival after resected NSCLC. The analysis of 342 patients showed that postoperative mucostasis, but not COPD, was associated with worse overall survival, recurrence-free survival, and cancer-specific survival after curative resection of NSCLC.
Article
Oncology
Johannes Fosselteder, Gabriel Pabst, Tommaso Sconocchia, Angelika Schlacher, Lisa Auinger, Karl Kashofer, Christine Beham-Schmid, Slave Trajanoski, Claudia Waskow, Wolfgang Schoell, Heinz Sill, Armin Zebisch, Albert Woelfler, Daniel Thomas, Andreas Reinisch
Summary: This study established a human gene-engineered model of CALR mutation-associated MPN using CRISPR/Cas9 and adeno-associated viral vector-mediated knock-in strategy, which recapitulates the disease characteristics and reveals mutation-specific vulnerabilities with preferential sensitivity of CALR mutant cells to inhibition of the BiP chaperone and the proteasome. This humanized model provides a useful platform for testing novel therapeutic strategies in a human setting.
Letter
Oncology
Tommaso Sconocchia, Johannes Fosselteder, Lisa Auinger, Erdem Oezkaya, Theresa Benezeder, Magdalena Lang, Christine Beham-Schmid, Gerald Hoefler, Armin Zebisch, Albert Woelfler, Heinz Sill, Peter Wolf, Herbert Strobl, Andreas Reinisch