Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemia

Integrative prognostic risk score in acute myeloid leukemia with normal karyotype

(2011) F. Damm et al.   BLOOD

Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia

(2011) I. Fried et al.   HAEMATOLOGICA

Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy

(2011) L S Steelman et al.   LEUKEMIA

Therapy-related myeloid neoplasms: pathobiology and clinical characteristics

(2010) H Sill et al.   BRITISH JOURNAL OF PHARMACOLOGY

Acute myeloid leukemia with mutated NPM1: diagnosis, prognosis and therapeutic perspectives

(2010) Brunangelo Falini et al.   CURRENT OPINION IN ONCOLOGY

AML with CBFB–MYH11 rearrangement demonstrate RAS pathway alterations in 92% of all cases including a high frequency of NF1 deletions

(2010) C Haferlach et al.   LEUKEMIA

Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma

(2010) Nallasivam Palanisamy et al.   NATURE MEDICINE

Nf1 deficiency cooperates with oncogenic K-RAS to induce acute myeloid leukemia in mice

(2009) B. A. Cutts et al.   BLOOD

Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia

(2009) F. C. Guibal et al.   BLOOD

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

(2009) H. Dohner et al.   BLOOD

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

(2009) J. W. Vardiman et al.   BLOOD

Modelling oncogenic Ras/Raf signalling in the mouse

(2009) Florian A Karreth et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7

(2009) Surabhi Dangi-Garimella et al.   EMBO JOURNAL

PML–RARα initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors

(2009) S Wojiski et al.   LEUKEMIA

Loss of RAF kinase inhibitor protein is a somatic event in the pathogenesis of therapy-related acute myeloid leukemias with C-RAF germline mutations

(2009) A Zebisch et al.   LEUKEMIA

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction

(2009) S Baritaki et al.   ONCOGENE

Determination of Ras-GTP and Ras-GDP in patients with acute myelogenous leukemia (AML), myeloproliferative syndrome (MPS), juvenile myelomonocytic leukemia (JMML), acute lymphocytic leukemia (ALL), and malignant lymphoma: assessment of mutational and indirect activation

(2008) D. Raepple et al.   ANNALS OF HEMATOLOGY

High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients

(2008) J. W. Tyner et al.   BLOOD

Paediatric myelodysplastic syndromes and juvenile myelomonocytic leukaemia: molecular classification and treatment options

(2008) Charlotte Marie Niemeyer et al.   BRITISH JOURNAL OF HAEMATOLOGY

Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor

(2008) Alexey E Granovsky et al.   CELL RESEARCH

M4 acute myeloid leukemia: the role of eosinophilia and cytogenetics in treatment response and survival. The GIMEMA experience

(2008) A. Pulsoni et al.   HAEMATOLOGICA

Phospho-ERK Staining Is a Poor Indicator of the Mutational Status of BRAF and NRAS in Human Melanoma

(2008) Roland Houben et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia

(2008) P D Emanuel   LEUKEMIA

Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia

(2008) L S Steelman et al.   LEUKEMIA

Survival Signaling by C-RAF: Mitochondrial Reactive Oxygen Species and Ca2+ Are Critical Targets

(2008) A. V. Kuznetsov et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia

(2008) Richard F. Schlenk et al.   NEW ENGLAND JOURNAL OF MEDICINE