Article
Polymer Science
Saurabh Bhatia, Ahmed Al-Harrasi, Mohammed Said Al-Azri, Sana Ullah, Hafiz A. Makeen, Abdulkarim M. Meraya, Mohammed Albratty, Asim Najmi, Md Khalid Anwer
Summary: This study investigates the fabrication of gelatin-casein-based edible films (GC-EFs) crosslinked with gallic acid (GA) and analyzes their physiochemical characteristics and surface properties. The results show that the addition of GA enhances the thermal stability and surface properties of the films. Films with higher concentrations of GA exhibit improved surface properties and denser structures, as well as lower swelling degree, higher mechanical parameters, and increased transparency.
Article
Engineering, Biomedical
Espen Helgeland, Ahmad Rashad, Elisabetta Campodoni, Oyvind Goksoyr, Torbjorn ostvik Pedersen, Monica Sandri, Annika Rosen, Kamal Mustafa
Summary: This study aimed to improve the physical properties of 3D printed gelatin scaffolds for cartilage regeneration by identifying non-toxic and effective crosslinking methods. The dual-crosslinked scaffolds exhibited the highest degree of crosslinking and the greatest resistance to degradation, promoted chondrogenic differentiation of mesenchymal stem cells, and had potential application in tissue engineering of TMJ condylar cartilage.
BIOMEDICAL MATERIALS
(2021)
Article
Engineering, Biomedical
Mani Diba, Gerry L. Koons, Matthew L. Bedell, Antonios G. Mikos
Summary: This study presents the 3D printing of novel biomaterial constructs with shape memory behavior using photo-reactive gelatin nanoparticles as colloidal building blocks. The UV-induced covalent interparticle crosslinks significantly enhance the mechanical properties of printed constructs and provide remarkable control over swelling, degradation, and biomolecule release behavior. These novel colloidal inks show great potential to serve as bio-inks for 3D printing of biomaterials with shape-morphing features in tissue engineering and regenerative medicine applications.
Article
Chemistry, Applied
Lulu Zhu, Xiao Sun, Yan Fan, Yangfan Wang, Xin Qi, Hu Hou
Summary: In this study, the thermal stability of ready-to-eat sea cucumbers (RSC) was enhanced using gallic acid (GA) and chlomgenic acid (CA). The treatment led to an increase in hardness and a decrease in free water content of RSC. Collagen fibers showed increased aggregation and decreased porosity. The resulting improvement in thermal stability was evidenced by higher peak temperatures. This research provides a theoretical basis for prolonging the storage life of RSC.
Article
Engineering, Manufacturing
Ting -Yu Cheng, Yi-Chen Weng, Chien -Hua Chen, Ying-Chih Liao
Summary: A reactive binder jetting process is developed to simplify the manufacturing of 3D objects. The process involves using a multiple-jetting method to create hydrogel patterns on a gypsum powder bed. The addition of trivalent or tetravalent cationic ions improves the mechanical strength and water resistance of the printed samples, with the best results achieved using tetravalent Zr4+ ink.
ADDITIVE MANUFACTURING
(2023)
Review
Polymer Science
Robert D. Murphy, Ronnie V. Garcia, Andreas Heise, Andreas J. Heise
Summary: Peptide hydrogels are critical building blocks for various scientific applications due to their high water capacity, tunable mechanical properties, and modular synthetic design. They are particularly interesting in the biomedical field due to their biomimetic structure and biocompatibility, making them suitable for 3D printing matrices. This review discusses two strategies for preparing peptide hydrogels using solid-phase peptide synthesis and N-carboxyanhydride ring opening polymerization, and explores their applicability in 3D printing and potential research directions.
PROGRESS IN POLYMER SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Lucia G. . De la Cruz, Tobias Abt, Noel Leon, Miguel Sanchez-Soto
Summary: This study synthesized robust all-natural aerogel composites with low density, good compressive properties, and low thermal conductivities by incorporating nanoscale montmorillonite and tannic acid into a gelatin matrix. The aerogels showed excellent flame retardancy and durable superhydrophobicity, making them promising eco-friendly alternatives to synthetic polymer-based foams.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Polymer Science
Rita I. R. Ibanez, Ronaldo J. F. C. do Amaral, Rui L. Reis, Alexandra P. Marques, Ciara M. Murphy, Fergal J. O'Brien
Summary: The study found that introducing a porous architecture through 3D printing GelMA scaffolds can enhance healthy fibroblast activity while inhibiting myofibroblast activation, leading to reduced scar formation.
Article
Agriculture, Multidisciplinary
Paola A. Gimenez, Antonela E. Bergesse, Agustin Lucini Mas, Marcela L. Martinez, Agustin Gonzalez
Summary: This study investigated the microencapsulation of chia oil (CO) using gallic acid (GA) crosslinked-soy protein isolate (SPI) as a wall material and its effect on oxidative stability. The results showed that microcapsules had low moisture content and high encapsulation efficiency. The microencapsulated oil with crosslinked wall material exhibited better oxidative stability and increased antioxidant activity during in vitro digestion.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Jingwen Li, Mingxin Wu, Wenhui Chen, Haiyang Liu, Di Tan, Shengnan Shen, Yifeng Lei, Longjian Xue
Summary: Inspired by plant structures, a multiple compartmentalized capsular structure for controlled drug delivery was successfully designed and manufactured using bioprinting technology. This structure allows customized drug release with sustained release for about 410 minutes, offering possibilities for personalized medicine.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Pharmacology & Pharmacy
Atabak Ghanizadeh Tabriz, Uttom Nandi, Andrew P. Hurt, Ho-Wah Hui, Shyam Karki, Yuchuan Gong, Sumit Kumar, Dennis Douroumis
Summary: This study utilized Fusion Deposition Modelling (FDM) to design and fabricate a bilayer tablet for tuberculosis treatment, with one drug releasing in the stomach and another in the upper intestine. The bilayer tablet preparation involved hot melt extrusion and 3D printing, optimizing drug release and ensuring consistent drug-containing layers. The study demonstrated the potential application of FDM technology in developing personalized clinical treatment options for oral fixed-dose combinations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Engineering, Biomedical
Cigdem Bilici, Asena G. Tatar, Efsun Senturk, Caner Dikyol, Bahattin Koc
Summary: Recent studies have shown promising outcomes in 3D bioprinting of GelMA hydrogels with cell-laden structures for tissue engineering applications. However, the reliance on photo-induced gelation processes and the lack of alternative crosslinking methods have posed challenges. This study presents a novel approach using embedded bioprinting and bisulfite-initiated radical polymerization to form cell-laden GelMA hydrogel constructs, resulting in printed structures with high cell viability.
Article
Chemistry, Applied
Chaofan Guo, Min Zhang, Sakamon Devahastin
Summary: The feasibility of using microwave heating and microcapsules as stimulus-response materials to achieve color and aroma changes in 3D-printed buckwheat dough containing yellow flesh peach was explored. Addition of microcapsules increased the storage and loss moduli of the dough, while also enhancing printing performance, especially during microwave heating.
FOOD HYDROCOLLOIDS
(2021)
Article
Engineering, Biomedical
Abudureheman Maihemuti, Han Zhang, Xiang Lin, Yangyufan Wang, Zhihong Xu, Dagan Zhang, Qing Jiang
Summary: In this study, a three-dimensional printed porous multilayer scaffold made of cold-water fish skin gelatin was developed for osteoarticular cartilage regeneration. The scaffold mimics the structure of native cartilage, allowing chondrocytes to adhere, proliferate, and communicate, as well as transport nutrients and prevent further joint damage. Moreover, the gelatin scaffolds were found to be nonimmunogenic, nontoxic, and biodegradable. Implanting the scaffold into rat cartilage defects resulted in satisfactory repair outcomes in an animal model. Therefore, cold-water fish skin gelatin scaffolds have promising applications in regenerative medicine.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Applied
Shizhang Yan, Qi Wang, Yang Li, Baokun Qi
Summary: Carbodiimide hydrochloride/N-hydroxysuccinimide was used to mediate the grafting of gallic acid (GA) with soybean protein isolate (SPI), resulting in SPI-GA conjugates and hydrogels. The SPI-GA materials showed excellent antioxidant properties and increased flexibility of the SPI structure. The SPI-GA hydrogel was fabricated through covalent/non-covalent cross-linking mechanisms and its properties were influenced by the amount of GA grafted.
Article
Biochemistry & Molecular Biology
Iratxe Zarandona, Daniela M. Correia, Joana Moreira, Carlos M. Costa, Senentxu Lanceros-Mendez, Pedro Guerrero, Koro de la Caba
Summary: Chitosan-pectin films containing Fe3O4 magnetic nanoparticles were prepared using solution casting method, creating biopolymer-based magnetically active materials. Physical interactions between the matrix and nanoparticles were confirmed by FTIR spectra and DSC results. The structure of the films was influenced by the interactions, leading to changes in mechanical properties. VSM and electrical analysis showed that the films exhibited ferrimagnetic behavior and increased dielectric constant with higher nanoparticle concentration. Additionally, the films demonstrated enhanced antimicrobial activity against both Gram-negative and Gram-positive bacteria. These findings highlight the potential of chitosan-pectin films with Fe3O4 magnetic nanoparticles in active and intelligent food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Alaitz Etxabide, Maite Arregi, Sara Cabezudo, Pedro Guerrero, Koro de la Caba
Summary: Whey protein films containing ascorbic acid were developed for food packaging applications. Non-covalent interactions between whey protein and ascorbic acid were observed, and the addition of ascorbic acid significantly improved the UV-Vis light absorbance capacity of whey protein films, which is important for protecting UV-Vis light-induced lipid oxidation in food. Furthermore, the environmental assessment showed that scaling up film manufacture could reduce the environmental impacts, particularly electricity consumption.
Article
Engineering, Biomedical
Teresa Carranza, Martin Zalba-Balda, Mari Jose Barriola Baraibar, Koro de la Caba, Pedro Guerrero
Summary: Sterilization is a crucial step in the development of bioinks for tissue engineering. This study compared the effects of UV radiation, filtration, and autoclaving on alginate/gelatin inks. The results showed that UV samples exhibited shear thinning behavior and produced 3D-printed constructs with better shape fidelity. FTIR analysis confirmed the prevalence of α-helix structure in UV samples. This work emphasizes the importance of sterilization in the research field of bioinks.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Chemistry, Multidisciplinary
Mireia Andonegi, Daniela Correia, Nelson Pereira, Manuel Salado, Carlos M. Costa, Senentxu Lanceros-Mendez, Koro de la Caba, Pedro Guerrero
Summary: With the sustainable development goals in mind, sustainable sensors based on natural polymers are necessary for the widespread use of the Internet of Things (IoT). This study focuses on collagen-based blends with different ionic liquids (ILs) and their effects on mechanical, thermal, and electrical properties. The best electrical response is achieved with a collagen/[Ch][Seri] sample, which exhibits lower tensile strength and higher elongation at break. The functional response of collagen-IL films on a resistive touch sensor shows potential for sustainable touch sensing devices.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Engineering, Biomedical
Jone Uranga, Teresa Carranza, Miriam Penalba, Koro de la Caba, Pedro Guerrero
Summary: Cellulose-containing residue from agar production was used as a filler in soy protein-based hydrogels for 3D printing without further purification. The addition of cellulose led to morphological changes and improved hardness and shape recovery of the 3D-printed products. The physicochemical characterization revealed high swelling capacity and integrity of the 3D-printed products in wet conditions, indicating their potential for circular economy and efficient resource utilization.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Engineering, Biomedical
Teresa Carranza, Jone Uranga, Ainhoa Irastorza, Ander Izeta, Pedro Guerrero, Koro de la Caba
Summary: Novel scaffolds based on natural polymers were developed by combining 3D printing and electrospinning techniques. The 3DP ink was prepared with gelatin and chitin, while the ES ink was prepared with gelatin and poly(vinyl alcohol) (PVA). The combination of these biopolymers resulted in a multilayered scaffold with unique properties suitable for tissue regeneration.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Nanoscience & Nanotechnology
Jingjunjiao Long, Yitian Wang, Minxun Lu, Alaitz Etxabide Etxeberria, Yong Zhou, Peiyang Gu, Ping Song, Li Min, Yi Luo, Ashveen V. Nand, Sudip Ray, Yong Sun, Yujiang Fan, Chongqi Tu, Xingdong Zhang
Summary: Magnetic stimulation can regulate cell fate and promote osteogenesis. This study developed a magnetized hydrogel with programmed release of PTH and simultaneous magnetic actuation to enhance bone regeneration. In vitro and in vivo experiments confirmed the osteogenic effects and accelerated bone healing of the hydrogel.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Electrochemistry
Joao P. Serra, Jone Uranga, Renato Goncalves, Carlos M. Costa, Koro de la Caba, Pedro Guerrero, Senentxu Lanceros-Mendez
Summary: This study develops membranes based on soy protein and cellulose from waste materials, which are used as battery separator membranes for sustainable energy storage systems. The membranes show excellent compatibility with the electrolyte, good swelling properties, and thermal stability. They also demonstrate high ionic conductivity, lithium transference number, and battery performance.
ELECTROCHIMICA ACTA
(2023)
Article
Polymer Science
Mireia Andonegi, Daniela M. Correia, Nelson Pereira, Margarida M. Fernandes, Carlos M. Costa, Senentxu Lanceros-Mendez, Koro de la Caba, Pedro Guerrero
Summary: This study focuses on the development of collagen/silver nanowires (Ag NWs) composites for resistive sensor applications, aiming to replace synthetic polymers with natural polymers. The study reveals the physical interactions between hydroxyl groups in collagen and Ag NWs, as well as the well dispersion of Ag NWs within the collagen matrix. The addition of Ag NWs improves the thermal stability of collagen without affecting its triple helix structure. The composites with 6 wt% of Ag NWs exhibit the highest electrical conductivity of 0.0515 S cm-1, making them suitable for sustainable multifunctional sensing composites in next generation touch sensing electronic devices.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Mireia Andonegi, Daniela M. Correia, Nelson Pereira, Carlos M. Costa, Senentxu Lanceros-Mendez, Koro de la Caba, Pedro Guerrero
Summary: This work presents the development of collagen films containing graphene oxide nanoparticles (GO NPs), which exhibit enhanced thermal stability, hydrophilicity, and mechanical strength, making them suitable for sustainable sensor applications.
Article
Chemistry, Applied
Teresa Carranza, Pedro Guerrero, Koro de la Caba, Alaitz Etxabide
Summary: 3D printing is utilized to create texture-modified food that is both nutritious and appealing for special consumer needs, specifically the elderly with swallowing disorders. In this study, vegetable-based food with varying internal 3D structures was successfully printed using 3D printing technology. The addition of red cabbage in the food formulation affected the viscosity and moduli, resulting in a solid-like behavior conducive to maintaining the shape and size of the printed food samples. All food samples were classified as transitional food according to the IDDSI framework.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Applied
Deepika Sharma, Gregory R. Ziegler, Federico M. Harte
Summary: Fabrication of bead-free nanofibers from pure casein is challenging due to its self-aggregation tendency. In this study, the influence of pH, ethanol content, ionic environment, and casein concentration on the solubility and solution characteristics of casein-based spinning dopes was analyzed. The addition of tetrasodium pyrophosphate (TSPP) reduced bead defects and improved the properties of the nanofibers. The viscosity of the solution depended on the casein concentration, and bead-free nanofibers were obtained at a concentration higher than the entanglement concentration (C-e).
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Smriti Shrestha, Leonie Van't Hag, Victoria Haritos, Sushil Dhital
Summary: This study investigated the pasting properties, structural formation, and molecular changes of mungbean, green lentil, and yellow pea proteins during high moisture extrusion (HME). The results showed that protein composition and conformation played important roles in the structural development and molecular changes during HME.
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Shi Liu, Na Sun, Kunyu Ren, Xubin Tan, Lanxin Li, Zhe Wang, Shicheng Dai, Xiaohong Tong, Huan Wang, Lianzhou Jiang
Summary: In this study, self-assembled soy protein nanoparticles (SPN) were successfully prepared and used for encapsulation of lutein, 8-carotene, and curcumin. The encapsulated natural pigments showed improved stability, especially curcumin. This study provides a new approach for extending the use of lipophilic natural edible pigments in food products.
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Jianming Wang, Ziyun Liu, Kaiwen Zheng, Zhe Yuan, Chen Yang
Summary: By combining with high methoxyl pectin (HMP), the emulsifying properties of oat protein isolate (OPI) were improved. The OPI-HMP complex formed soluble complexes under specific pH conditions, exhibiting excellent emulsifying activity and stability, making it suitable as a delivery system for lipid soluble bioactive compounds in food and biomedical applications.
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Zihao Yin, Junzhe Zou, Mengwei Wang, Ruonan Huang, Yuemiao Qian, Mingyong Zeng, Fangwei Li
Summary: Phycocyanin, a protein prone to degradation under acidic conditions and unstable at high temperatures, has limited application in food. This study successfully combined phycocyanin with whey protein isolate using protein coprecipitation and chitosan coating to form composite particles, which maintained the color and colloidal stability of phycocyanin. The composite particles showed minimal color changes and retained high pigment retention rates after heating. Furthermore, the composite particles exhibited excellent antioxidant capacity. This breakthrough expands the application of phycocyanin in acidic beverages and other food forms.
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Yuting Su, Qian Zhou, Hui Xu, Manting Huang, Siqian Li, Jiayi He, Ka-Wing Cheng, Mingfu Wang
Summary: By developing the CM-Cur/QT complex, the solubility and stability of quercetin were improved, leading to enhanced bioavailability. The complex showed increased bio-accessibility and antioxidant efficacy during in vitro digestion, and facilitated the internalization of quercetin in macrophages, exerting a potential synergistic anti-inflammatory effect.
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Sheliang Zhao, David Julian Mcclements, Xuebo Liu, Fuguo Liu
Summary: The low oral bioavailability of some bioactive ingredients is a challenge in the supplement and functional food areas. This study designs natural carriers that can simultaneously deliver both hydrophobic and hydrophilic bioactive ingredients, thereby increasing their ability to exert synergistic effects.
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Md Easdani, Shabbir Ahammed, Md Nazmus Saqib, Fei Liu, Fang Zhong
Summary: Compiling hydrophobic and hydrophilic proteins to form a mechanically reliable bilayer film with improved water barrier properties and hydrophobicity is challenging. By introducing cross-linkers, the film exhibits compatible and flexible surfaces, enhanced color and transparency, and controlled water vapor permeability. The bilayer film shows potential for improving value-added functional properties.
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Tian-Qi Zhou, Xue-Chen Wang, Ling-Yi Gao, Jia-Nan Yan, Hai-Tao Wu
Summary: This study investigated the synergetic gelation of curdlan gum (CG) and gellan gum (GG) at different ratios. The optimal gelation was achieved at a mass ratio of 1:1 and a total concentration of 0.6%. The gel properties were influenced by the CG/GG ratio, with the strongest gel observed at a ratio of 5:5. The improved gel properties were attributed to hydrogen bonds between CG and GG. The CG/GG binary composite gel exhibited increased water holding capacity as the CG/GG ratio decreased. Furthermore, the microstructure of the CG/GG gel was denser and more homogeneous, supporting its stronger gel rigidity and water holding capacity.
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Jialin Sun, Zihao Wei, Changhu Xue
Summary: In this study, porous gelatin microspheres (PGMs) with surface and internal porous structure were developed for the controlled release and rapid functional response of anthocyanins (ANCs). The loading of ACNs was achieved through electrostatic interaction, resulting in a high loading capacity. ACN@PGMs exhibited long-term controlled release, improved storage stability, and ammonia responsiveness, making them suitable for applications as antioxidant factors and food freshness indicators in the food industry.
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Xinlai Dou, Yanling Hao, Ying Sun, Pin Yang, Linlin Liu, Yinyuan He, Yanguo Shi, Chunhua Yang, Fenglian Chen
Summary: In this study, chitosan hydrochloride/carboxymethyl starch sodium (CHC-CMS-Na) nanogels were prepared as a baking additive and showed potential in improving bread quality.
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Xinya Wang, H. Douglas Goff, Steve W. Cui
Summary: This study thoroughly investigated the synergistic gelation between yellow mustard gum (YMG) and kappa-carrageenan using multiple techniques. The results showed that the interaction between YMG and kappa-carrageenan was mainly polymer associations, and YMG affected the gel formation process of kappa-carrageenan.
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Jielong Zhang, Dasong Liu, Xiumei Tao, Jun Tang, Xiaoyu Peng, Thom Huppertz, Xiaoming Liu, Peng Zhou
Summary: The effect of enzymatic dephosphorylation on the structure of casein micelles in caprine micellar casein concentrate was studied. The results showed that with increasing dephosphorylation, the molar mass decreased, the radii decreased, the hydration increased, and the internal protein inhomogeneity disappeared.
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Wentao Ma, Chao Yuan, Bo Cui, Tian Gao, Li Guo, Bin Yu, Meng Zhao, Feixue Zou
Summary: This study investigated the influence of highly-branched cyclic dextrin (HBCD) on the physiochemical properties of x-carrageenan (KC) gels. The addition of HBCD significantly enhanced the storage modulus and freeze-thaw stability of KC gels. HBCD promoted the distribution of KC chains and aggregation of KC helixes, resulting in a compact network structure and reduced water loss. Furthermore, HBCD strengthened the thermal reversibility of KC gels through enhanced hydrogen-bonding interactions.
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Ya-Ru Wang, Qin Yang, Yi-Xuan Jiang, Han-Qing Chen
Summary: This study successfully improved the aqueous solubility, thermal stability, and antioxidant activity of RES by using ovalbumin fibrils as nanocarriers. The pH value was found to have an impact on the formation and properties of the complex, with the best interaction observed at pH 2.0.
FOOD HYDROCOLLOIDS
(2024)
