Review
Pharmacology & Pharmacy
Moshe Lapidot, Srinivas Vinod Saladi, Ravi Salgia, Martin Sattler
Summary: Despite the need for new therapeutic options for malignant pleural mesothelioma (MPM), treatment advances have been disappointing. Drug resistance is common and surgery only benefits a subset of patients. MPM is a heterogeneous disease with a low mutation rate, and current understanding of its molecular mechanisms is limited. Epigenetic regulation may lead to immune evasion and transformation in MPM. In addition, the low efficacy of immune checkpoint inhibitors may be due to suppression of genes involved in anti-tumor immune response.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Xueyin Zhou, Ting Ren, Hongyuan Zan, Chunyan Hua, Xufeng Guo
Summary: Esophageal cancer is the sixth most common cause of cancer death globally, and current conventional therapeutic strategies still have limited efficacy. New immune checkpoint pathways have become a focus of research, but only a small fraction of patients benefit from existing immune checkpoint inhibitors, posing a challenge of immunoresistance.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Margaret A. McBride, Tazeen K. Patil, Julia K. Bohannon, Antonio Hernandez, Edward R. Sherwood, Naeem K. Patil
Summary: Sepsis is a leading cause of death in intensive care units, with survivors often experiencing immunosuppression and recurrent infections. Current treatment relies on supportive care and with the increasing incidence of antibiotic-resistant microbes, there is a need to discover novel therapeutics. Studies have shown that specific cell surface inhibitory immune checkpoint receptors and ligands play crucial roles in mediating the balance between host immune competency and immunosuppression in sepsis. Targeting these immune checkpoints may improve host resistance to infection and serve as a means of individualized therapy for septic patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yujia Zhai, Reza Moosavi, Mingnan Chen
Summary: Autoimmune diseases result from immune tolerance failure, which is sustained by interactions between immune stimulation and immune regulation. Immune checkpoints play crucial roles in maintaining immune tolerance, and therapeutics targeting immune checkpoints show potential in treating autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Emanuela Senjor, Janko Kos, Milica Perisic Nanut
Summary: Cysteine cathepsins, the most abundant proteases in lysosomes, play essential roles in various cellular processes. Their upregulation is associated with pathological conditions such as cancer and neurodegeneration. This review provides an overview of their involvement in immune disorders and suggests potential targeting options.
Review
Biochemistry & Molecular Biology
Areeba Nisar, Zubair Ahmed, Hsiangkuo Yuan
Summary: Migraine is a debilitating neurological condition that affects many patients' quality of life. Despite the success of new therapies, not all patients benefit significantly. Understanding the mechanisms involved in migraine can lead to the discovery of novel therapeutic targets for improved treatment options.
Article
Oncology
Li-Hong He, Xiao-Zhen Zhang, Meng-Yi Lao, Han-Jia Zhang, Han-Shen Yang, Xue-Li Bai
Summary: This study found that NRPs, especially NRP1, serve as diagnostic and prognostic biomarkers in malignant tumors, including pancreatic cancer, and have potential immunoregulatory functions in cancer therapy. NRPs have potential applications and research significance in the treatment of pancreatic cancer.
Review
Cell Biology
Pernille Y. O. Nielsen, Justyna Okarmus, Morten Meyer
Summary: Parkinson's disease is associated with mitochondrial dysfunction, oxidative stress, defects in mitophagy, and oc-synuclein-positive inclusions. The deubiquitinating enzymes (DUBs) play a role in regulating mitophagy and oc-synuclein aggregation. This paper describes the DUBs associated with Parkinson's disease and their potential as therapeutic targets.
Review
Biotechnology & Applied Microbiology
Wayne C. Drevets, Gayle M. Wittenberg, Edward T. Bullmore, Husseini K. Manji
Summary: Compelling evidence suggests that immune mechanisms play a role in the pathogenesis of major depressive disorder (MDD) and drugs targeting immune targets have shown efficacy in improving depressive symptoms. By defining narrower patient subgroups based on biology, the treatment response rates can be increased, which is a major advancement in clinical psychiatry.
NATURE REVIEWS DRUG DISCOVERY
(2022)
Review
Immunology
Bulmaro Cisneros, Ian Garcia-Aguirre, Juan Unzueta, Isabel Arrieta-Cruz, Oscar Gonzalez-Morales, Juan M. Dominguez-Larrieta, Aura Tamez-Gonzalez, Gerardo Leyva-Gomez, Jonathan J. Magana
Summary: The function of the immune system declines during aging, leading to compromised response against pathogens and chronic low-grade inflammation. This review discusses the molecules and mechanisms that regulate the relationship between immunosenescence and inflammaging, as well as therapeutic strategies to improve immunity in aged individuals.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Chang Tian, Jiaying Liu, Xin Di, Shan Cong, Min Zhao, Ke Wang
Summary: The study identified potential diagnostic markers for sepsis by analyzing the differential expression of circRNAs in serum exosomes, with hsa_circRNA_104484 and hsa_circRNA_104670 showing promise as novel diagnostic biomarkers.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Jinhang Zhang, Qinhui Liu, Jinhan He, Yanping Li
Summary: Liver fibrosis is a serious liver disease that can progress to cirrhosis and cancer if untreated. Current treatments are limited in efficacy and costly, with liver transplantation being an option. There is a need to clarify the mechanism of liver fibrosis and search for novel therapeutic targets to develop more effective treatments.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Immunology
Wen Xu, Sheng Wan, Bo Xie, Xiuzu Song
Summary: Alopecia areata (AA) is a non-scarring hair loss disorder caused by autoimmunity, but the exact functional mechanism remains unclear. Recent studies showed that immune-related cells and molecules affect AA through autocrine and paracrine signals mediated by various cytokines, chemokines, and growth factors. In addition, adipose-derived stem cells, gut microbiota, hair follicle melanocytes, non-coding RNAs, and specific regulatory factors play critical roles in intercellular communication, suggesting potential new targets for AA therapy. This review discusses the latest research on the possible pathogenesis and therapeutic targets of AA.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Rossella Paolini, Rosa Molfetta
Summary: CD155, also known as the poliovirus receptor, is often overexpressed in tumors and promotes cell migration and proliferation. It plays an immunomodulatory role by binding to receptors on immune cells. DNAM-1 is involved in anti-tumor immune surveillance, while TIGIT acts as an immune checkpoint receptor, counterbalancing DNAM-1. Targeting CD155 and enhancing DNAM-1 function are promising therapeutic approaches, and clinical trials for anti-TIGIT treatment are already underway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Zhixing Zhu, Stephen Chambers, Yiming Zeng, Madhav Bhatia
Summary: Sepsis is a potentially lethal condition caused by failure to control initial infection, and its pathophysiology is complex and not fully understood. Gaseous mediators, including nitric oxide, carbon monoxide, and hydrogen sulfide, play important roles in the development of sepsis and offer potential therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pablo Palazon-Riquelme, Jonathan D. Worboys, Jack Green, Ana Valera, Fatima Martin-Sanchez, Carolina Pellegrini, David Brough, Gloria Lopez-Castejon
Review
Immunology
Pablo Palazon-Riquelme, Gloria Lopez-Castejon
Article
Multidisciplinary Sciences
Jack P. Green, Shi Yu, Fatima Martin-Sanchez, Pablo Pelegrin, Gloria Lopez-Castejon, Catherine B. Lawrence, David Brough
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Pharmacology & Pharmacy
Rocchina Colucci, Carolina Pellegrini, Matteo Fornai, Erika Tirotta, Luca Antonioli, Cecilia Renzulli, Emilia Ghelardi, Elena Piccoli, Daniela Gentile, Laura Benvenuti, Gianfranco Natale, Federica Fulceri, Pablo Palazon-Riquelme, Gloria Lopez-Castejon, Corrado Blandizzi, Carmelo Scarpignato
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Victor S. Tapia, Michael J. D. Daniels, Pablo Palazon-Riquelme, Matthew Dewhurst, Nadia M. Luheshi, Jack Rivers-Auty, Jack Green, Elena Redondo-Castro, Philipp Kaldis, Gloria Lopez-Castejon, David Brough
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Review
Biochemistry & Molecular Biology
Gloria Lopez-Castejon
Article
Biochemistry & Molecular Biology
Carolina Pellegrini, Simona Daniele, Luca Antonioli, Laura Benvenuti, Vanessa D'Antongiovanni, Rebecca Piccarducci, Deborah Pietrobono, Valentina Citi, Eugenia Piragine, Lorenzo Flori, Chiara Ippolito, Cristina Segnani, Pablo Palazon-Riquelme, Gloria Lopez-Castejon, Alma Martelli, Rocchina Colucci, Nunzia Bernardini, Maria Letizia Trincavelli, Vincenzo Calderone, Claudia Martini, Corrado Blandizzi, Matteo Fornai
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Anna Gritsenko, Jack P. Green, David Brough, Gloria Lopez-Castejon
CYTOKINE & GROWTH FACTOR REVIEWS
(2020)
Article
Immunology
Triin Major, Alexandra L. Ball, John P. Stone, Rebecca J. Edge, Gloria Lopez-Castejon, Trygve Sjoberg, Anders Andreasson, David Brough, Stig Steen, Andrew J. Fisher, James E. Fildes
Summary: Pro-IL-1 beta and caspase-1 levels were significantly higher in the perfusate of lungs that did not recondition compared to reconditioned lungs. Inhibition of NLRP3 inflammasome reduced IL-1 beta release in a porcine EVLP model without impacting lung function or inflammation.
Article
Immunology
Anna Gritsenko, Shi Yu, Fatima Martin-Sanchez, Ines Diaz-del-Olmo, Eva-Maria Nichols, Daniel M. Davis, David Brough, Gloria Lopez-Castejon
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Shi Yu, Jack Green, Rose Wellens, Gloria Lopez-Castejon, David Brough
Summary: The inhibition of V-ATPase has been shown to exacerbate LPS-induced NLRP3 inflammasome activation in primary human monocytes, leading to an alternative pathway characterized by NLRP3-dependent, K+ efflux-independent, ASC oligomerization and caspase-1 activation. This suggests that V-ATPases play additional roles during NLRP3 inflammasome activation in primary human monocytes.
Article
Pharmacology & Pharmacy
Carolina Pellegrini, Matteo Fornai, Laura Benvenuti, Rocchina Colucci, Valentina Caputi, Pablo Palazon-Riquelme, Maria Cecilia Giron, Anna Nericcio, Francesca Garelli, Vanessa D'Antongiovanni, Cristina Segnani, Chiara Ippolito, Monica Nannipieri, Gloria Lopez-Castejon, Pablo Pelegrin, Gyorgy Hasko, Nunzia Bernardini, Corrado Blandizzi, Luca Antonioli
Summary: The study showed that NLRP3 plays a role in regulating the interaction between enteric immune/inflammatory responses and the activation of substance P/NK1 pathways in obese mice, leading to colonic dysmotility. Identifying NLRP3 as a potential therapeutic target for treating bowel symptoms related to obesity.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Anna Gritsenko, Rodrigo Diaz-Pino, Gloria Lopez-Castejon
Summary: IL-37 is released following the activation of the canonical and alternative NLRP3 inflammasomes. The study proposes a novel pathway in which IL-37 is cleaved by caspase-1-independent mechanisms and released through differential pathways.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Review
Cell Biology
Paula Seoane, Bali Lee, Christopher Hoyle, Shi Yu, Gloria Lopez-Castejon, Martin Lowe, David Brough
JOURNAL OF CELL BIOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Channabasavaiah B. Gurumurthy, Aidan R. O'Brien, Rolen M. Quadros, John Adams, Pilar Alcaide, Shinya Ayabe, Johnathan Ballard, Surinder K. Batra, Marie-Claude Beauchamp, Kathleen A. Becker, Guillaume Bernas, David Brough, Francisco Carrillo-Salinas, Wesley Chan, Hanying Chen, Ruby Dawson, Victoria DeMambro, Jinke D'Hont, Katharine M. Dibb, James D. Eudy, Lin Gan, Jing Gao, Amy Gonzales, Anyonya R. Guntur, Huiping Guo, Donald W. Harms, Anne Harrington, Kathryn E. Hentges, Neil Humphreys, Shiho Imai, Hideshi Ishii, Mizuho Iwama, Eric Jonasch, Michelle Karolak, Bernard Keavney, Nay-Chi Khin, Masamitsu Konno, Yuko Kotani, Yayoi Kunihiro, Imayavaramban Lakshmanan, Catherine Larochelle, Catherine B. Lawrence, Lin Li, Volkhard Lindner, Xian-De Liu, Gloria Lopez-Castejon, Andrew Loudon, Jenna Lowe, Loydie A. Jerome-Majewska, Taiji Matsusaka, Hiromi Miura, Yoshiki Miyasaka, Benjamin Morpurgo, Katherine Motyl, Yo-ichi Nabeshima, Koji Nakade, Toshiaki Nakashiba, Kenichi Nakashima, Yuichi Obata, Sanae Ogiwara, Mariette Ouellet, Leif Oxburgh, Sandra Piltz, Ilka Pinz, Moorthy P. Ponnusamy, David Ray, Ronald J. Redder, Clifford J. Rosen, Nikki Ross, Mark T. Ruhe, Larisa Ryzhova, Ane M. Salvador, Sabrina Shameen Alam, Radislav Sedlacek, Karan Sharma, Chad Smith, Katrien Staes, Lora Starrs, Fumihiro Sugiyama, Satoru Takahashi, Tomohiro Tanaka, Andrew W. Trafford, Yoshihiro Uno, Leen Vanhoutte, Frederique Vanrockeghem, Brandon J. Willis, Christian S. Wright, Yuko Yamauchi, Xin Yi, Kazuto Yoshimi, Xuesong Zhang, Yu Zhang, Masato Ohtsuka, Satyabrata Das, Daniel J. Garry, Tino Hochepied, Paul Thomas, Jan Parker-Thornburg, Antony D. Adamson, Atsushi Yoshiki, Jean-Francois Schmouth, Andrei Golovko, William R. Thompson, K. C. Kent Lloyd, Joshua A. Wood, Mitra Cowan, Tomoji Mashimo, Seiya Mizuno, Hao Zhu, Petr Kasparek, Lucy Liaw, Joseph M. Miano, Gaetan Burgio