Human Endogenous Retroviruses and Type 1 Diabetes

Expression of endogenous retroviruses reflects increased usage of atypical enhancers in T cells

(2019) Saliha Azébi et al.   EMBO JOURNAL

pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis

(2019) David Kremer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-HERV-WEnv antibodies are correlated with seroreactivity against Mycobacterium avium subsp. paratuberculosis in children and youths at T1D risk

(2019) Magdalena Niegowska et al.   Scientific Reports

A new therapeutic approach for type 1 diabetes: Rationale for GNbAC1, an anti-HERV-W-Env monoclonal antibody

(2018) Francois Curtin et al.   DIABETES OBESITY & METABOLISM

Type 1 diabetes

(2018) Linda A DiMeglio et al.   LANCET

Amyotrophic Lateral Sclerosis: An Update for 2018

(2018) Björn Oskarsson et al.   MAYO CLINIC PROCEEDINGS

The life cycle of non-polio enteroviruses and how to target it

(2018) Jim Baggen et al.   NATURE REVIEWS MICROBIOLOGY

Human Endogenous Retroviruses in Neurological Diseases

(2018) Patrick Küry et al.   TRENDS IN MOLECULAR MEDICINE

Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells

(2018) Eseoghene Ifie et al.   DIABETOLOGIA

Coxsackievirus-B4E2 can infect monocytes and macrophages in vitro and in vivo

(2018) M.A. Benkahla et al.   VIROLOGY

Enterovirus infection and type 1 diabetes: unraveling the crime scene

(2018) T. Rodriguez-Calvo   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Rescuing the negative impact of human endogenous retrovirus envelope protein on oligodendroglial differentiation and myelination

(2018) Peter Göttle et al.   GLIA

Variation in proviral content among human genomes mediated by LTR recombination

(2018) Jainy Thomas et al.   Mobile DNA

Induction of Proinflammatory Multiple Sclerosis-Associated Retrovirus Envelope Protein by Human Herpesvirus-6A and CD46 Receptor Engagement

(2018) Benjamin Charvet et al.   Frontiers in Immunology

Dendritic cell recruitment and activation in autoimmunity

(2017) Silvano Sozzani et al.   JOURNAL OF AUTOIMMUNITY

Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress

(2017) Angela Lombardi et al.   JOURNAL OF AUTOIMMUNITY

Persistence of Coxsackievirus B4 in pancreatic ductal-like cells results in cellular and viral changes

(2017) E. K. Alidjinou et al.   Virulence

Type 1 Diabetes and Type 1 Interferonopathies: Localization of a Type 1 Common Thread of Virus Infection in the Pancreas

(2017) Virginie S.E. Jean-Baptiste et al.   EBioMedicine

Environmental insults: critical triggers for amyotrophic lateral sclerosis

(2017) Bing Yu et al.   Translational Neurodegeneration

The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis

(2017) Elena Morandi et al.   PLoS One

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

(2016) Sarah J. Richardson et al.   DIABETOLOGIA

MSRV envelope protein is a potent, endogenous and pathogenic agonist of human toll-like receptor 4: Relevance of GNbAC1 in multiple sclerosis treatment

(2016) Alexandra Madeira et al.   JOURNAL OF NEUROIMMUNOLOGY

NF-κB and IRF1 Induce Endogenous Retrovirus K Expression via Interferon-Stimulated Response Elements in Its 5′ Long Terminal Repeat

(2016) Mamneet Manghera et al.   JOURNAL OF VIROLOGY

Anti-coxsackievirus B4 (CV-B4) enhancing activity of serum associated with increased viral load and pathology in mice reinfected with CV-B4

(2016) Firas Elmastour et al.   Virulence

Immunoglobulin G-dependent enhancement of the infection with Coxsackievirus B4 in a murine system

(2016) Firas Elmastour et al.   Virulence

Roles for retrotransposon insertions in human disease

(2016) Dustin C. Hancks et al.   Mobile DNA

Human endogenous retrovirus W in brain lesions: Rationale for targeted therapy in multiple sclerosis

(2016) Jack van Horssen et al.   Multiple Sclerosis and Related Disorders

Human Endogenous Retrovirus and Neuroinflammation in Chronic Inflammatory Demyelinating Polyradiculoneuropathy

(2016) Raphaël Faucard et al.   EBioMedicine

Effects of Type 1 Diabetes-Associated IFIH1 Polymorphisms on MDA5 Function and Expression

(2015) Benjamin M. Looney et al.   Current Diabetes Reports

Immunoproteomic Profiling of Anti-Viral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays

(2015) Xiaofang Bian et al.   DIABETES

Monocytes of Patients with Type 1 Diabetes Harbour Enterovirus RNA

(2015) Enagnon Kazali Alidjinou et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Inflammatory response of endothelial cells to a human endogenous retrovirus associated with multiple sclerosis is mediated by TLR4

(2015) Alain Duperray et al.   INTERNATIONAL IMMUNOLOGY

The immunogenetics of multiple sclerosis: A comprehensive review

(2015) Jill A. Hollenbach et al.   JOURNAL OF AUTOIMMUNITY

CMV induces HERV-K and HERV-W expression in kidney transplant recipients

(2015) Massimiliano Bergallo et al.   JOURNAL OF CLINICAL VIROLOGY

The co-occurrence of multiple sclerosis and type 1 diabetes: Shared aetiologic features and clinical implication for MS aetiology

(2015) Prudence Tettey et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses

(2015) Lazaros Belbasis et al.   LANCET NEUROLOGY

Treatment Against Human Endogenous Retrovirus: A Possible Personalized Medicine Approach for Multiple Sclerosis

(2015) François Curtin et al.   Molecular Diagnosis & Therapy

Human endogenous retrovirus-K contributes to motor neuron disease

(2015) Wenxue Li et al.   Science Translational Medicine

Coxsackievirus B4 Can Infect Human Peripheral Blood-Derived Macrophages

(2015) Enagnon Alidjinou et al.   Viruses-Basel

Detection of a Low-Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes

(2014) Lars Krogvold et al.   DIABETES

Low HERV-K(C4) Copy Number Is Associated With Type 1 Diabetes

(2014) Mike J. Mason et al.   DIABETES

Role of epigenetics in EBV regulation and pathogenesis

(2014) Hans Helmut Niller et al.   Future Microbiology

Preclinical and early clinical development of GNbAC1, a humanized IgG4 monoclonal antibody targeting endogenous retroviral MSRV-Env protein

(2014) François Curtin et al.   mAbs

“Ménage à Trois”: The Evolutionary Interplay between JSRV, enJSRVs and Domestic Sheep

(2014) Alessia Armezzani et al.   Viruses-Basel

Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation

(2013) David Kremer et al.   ANNALS OF NEUROLOGY

Serum-Dependent Enhancement of Coxsackievirus B4-Induced Production of IFNα, IL-6 and TNFα by Peripheral Blood Mononuclear Cells

(2013) Enagnon Kazali Alidjinou et al.   JOURNAL OF MOLECULAR BIOLOGY

Human Endogenous Retrovirus Protein Activates Innate Immunity and Promotes Experimental Allergic Encephalomyelitis in Mice

(2013) Hervé Perron et al.   PLoS One

Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1

(2012) S. J. Richardson et al.   DIABETOLOGIA

Human cytomegalovirus infection is sensitive to the host cell DNA methylation state and alters global DNA methylation capacity

(2012) Atosa Esteki-Zadeh et al.   Epigenetics

Expression of Human Endogenous Retrovirus Type K (HML-2) Is Activated by the Tat Protein of HIV-1

(2012) M. J. Gonzalez-Hernandez et al.   JOURNAL OF VIROLOGY

Antibodies enhance the infection of phorbol-ester-differentiated human monocyte-like cells with coxsackievirus B4

(2012) A. Goffard et al.   MICROBES AND INFECTION

Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease

(2012) Hervé Perron et al.   Multiple Sclerosis Journal

Endogenous viruses: insights into viral evolution and impact on host biology

(2012) Cédric Feschotte et al.   NATURE REVIEWS GENETICS

Influence of Antipsychotic Drugs on Human Endogenous Retrovirus (HERV) Transcription in Brain Cells

(2012) Olivia Diem et al.   PLoS One

Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NF-κB Signalling

(2012) Julie Amyot et al.   PLoS One

Expression and Activation by Epstein Barr Virus of Human Endogenous Retroviruses-W in Blood Cells and Astrocytes: Inference for Multiple Sclerosis

(2012) Giuseppe Mameli et al.   PLoS One

Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis

(2011) Humberto M Garay-Malpartida et al.   BMC IMMUNOLOGY

Immunology in the clinic review series; focus on type 1 diabetes and viruses: role of antibodies enhancing the infection with Coxsackievirus-B in the pathogenesis of type 1 diabetes

(2011) D. Hober et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance

(2011) Maikel L. Colli et al.   PLoS Pathogens

Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

(2010) Renée Douville et al.   ANNALS OF NEUROLOGY

Multiple sclerosis-associated retrovirus and progressive disability of multiple sclerosis

(2010) S. Sotgiu et al.   Multiple Sclerosis Journal

Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host

(2010) Didier Hober et al.   Nature Reviews Endocrinology

The Human Endogenous Retrovirus Link between Genes and Environment in Multiple Sclerosis and in Multifactorial Diseases Associating Neuroinflammation

(2009) Hervé Perron et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

Effects of interferon-beta therapy on innate and adaptive immune responses to the human endogenous retroviruses HERV-H and HERV-W, cytokine production, and the lectin complement activation pathway in multiple sclerosis

(2009) Thor Petersen et al.   JOURNAL OF NEUROIMMUNOLOGY

Mechanisms and results of the antibody-dependent enhancement of viral infections and role in the pathogenesis of coxsackievirus B-induced diseases

(2009) Pierre Sauter et al.   MICROBES AND INFECTION

Multiple sclerosis-associated retroviral agent (MSRV)-stimulated cytokine production in patients with relapsing-remitting multiple sclerosis

(2009) M Saresella et al.   Multiple Sclerosis Journal

A part of the VP4 capsid protein exhibited by coxsackievirus B4 E2 is the target of antibodies contained in plasma from patients with type 1 diabetes

(2008) Pierre Sauter et al.   JOURNAL OF MEDICAL VIROLOGY

Increased Toll-Like Receptor (TLR) 2 and TLR4 Expression in Monocytes from Patients with Type 1 Diabetes: Further Evidence of a Proinflammatory State

(2007) Sridevi Devaraj et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM