Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

Decision making inxia2

(2013) Graeme Winter et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Advances in our understanding of the pathophysiology of Type 1 diabetes: lessons from the NOD mouse

(2013) Abhirup Jayasimhan et al.   CLINICAL SCIENCE

Proline substitution independently enhances H-2Dbcomplex stabilization and TCR recognition of melanoma-associated peptides

(2013) Hannes Uchtenhagen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions

(2013) David K. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T-cell Receptor Specificity Maintained by Altered Thermodynamics

(2013) Florian Madura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptide length determines the outcome of TCR/peptide-MHCI engagement

(2012) J. Ekeruche-Makinde et al.   BLOOD

Circulating Preproinsulin Signal Peptide-Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill  -Cells

(2012) D. Kronenberg et al.   DIABETES

Different affinity windows for virus and cancer-specific T-cell receptors: Implications for therapeutic strategies

(2012) Milos Aleksic et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The molecular determinants of CD8 co-receptor function

(2012) David K. Cole et al.   IMMUNOLOGY

T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting

(2012) Julia Ekeruche-Makinde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TCR/pMHC Optimized Protein crystallization Screen

(2012) Anna M. Bulek et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes

(2012) Anna M Bulek et al.   NATURE IMMUNOLOGY

Rethinking the term “pi-stacking”

(2012) Chelsea R. Martinez et al.   Chemical Science

T cell-driven initiation and propagation of autoimmune diabetes

(2011) Maria Bettini et al.   CURRENT OPINION IN IMMUNOLOGY

Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection

(2011) Yiyuan Yin et al.   EMBO JOURNAL

Structural and biophysical determinants of αβ T-cell antigen recognition

(2011) John S. Bridgeman et al.   IMMUNOLOGY

A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC

(2011) Dhruv K. Sethi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T-cell autoantigens in the non-obese diabetic mouse model of autoimmune diabetes

(2010) Jeffrey Babad et al.   IMMUNOLOGY

Modification of MHC Anchor Residues Generates Heteroclitic Peptides That Alter TCR Binding and T Cell Recognition

(2010) D. K. Cole et al.   JOURNAL OF IMMUNOLOGY

Real time detection of peptide–MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability

(2010) Kim M. Miles et al.   MOLECULAR IMMUNOLOGY

Design of Agonistic Altered Peptides for the Robust Induction of CTL Directed towards H-2Db in Complex with the Melanoma-Associated Epitope gp100

(2009) M. J.B. van Stipdonk et al.   CANCER RESEARCH

Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes

(2009) F. S. Wong et al.   DIABETES

T Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular Flexibility

(2009) Oleg Y. Borbulevych et al.   IMMUNITY

Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor

(2009) David K. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance

(2009) Stefan Tenzer et al.   NATURE IMMUNOLOGY

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Detection of low avidity CD8+ T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers

(2008) J. Joseph Melenhorst et al.   JOURNAL OF IMMUNOLOGICAL METHODS

T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding

(2008) David K. Cole et al.   MOLECULAR IMMUNOLOGY

Functional inhibition related to structure of a highly potent insulin-specific CD8 T cell clone using altered peptide ligands

(2007) Liliana G. Petrich de Marquesini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY