Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase

Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

(2011) Jeffrey A. Pfefferkorn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

(2011) Jeffrey A. Pfefferkorn et al.   MedChemComm

Turning enzymes ON with small molecules

(2010) Julie A Zorn et al.   Nature Chemical Biology

Evolution of vertebrate glucokinase regulatory protein from a bacterialN-acetylmuramate 6-phosphate etherase

(2009) Maria Veiga-da-Cunha et al.   BIOCHEMICAL JOURNAL

Investigation of Functionally Liver Selective Glucokinase Activators for the Treatment of Type 2 Diabetes

(2009) Gregory R. Bebernitz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Assessing the potential of glucokinase activators in diabetes therapy

(2009) Franz M. Matschinsky   NATURE REVIEWS DRUG DISCOVERY

Glucokinase and molecular aspects of liver glycogen metabolism

(2008) Loranne Agius   BIOCHEMICAL JOURNAL

Biophysical Characterization of the Interaction between Hepatic Glucokinase and Its Regulatory Protein

(2008) Oliver Anderka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric regulation and catalysis emerge via a common route

(2008) Nina M Goodey et al.   Nature Chemical Biology