Association of common gene variants in glucokinase regulatory protein with cardiorenal disease: A systematic review and meta-analysis

Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities

(2017) Venexia M Walker et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Executive summary of the 2017 KDIGO Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD) Guideline Update: what’s changed and why it matters

(2017) Markus Ketteler et al.   KIDNEY INTERNATIONAL

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

(2017) Wei Zhao et al.   NATURE GENETICS

Association analyses based on false discovery rate implicate new loci for coronary artery disease

(2017) Christopher P Nelson et al.   NATURE GENETICS

A Common Gene Variant in Glucokinase Regulatory Protein Interacts With Glucose Metabolism on Diabetic Dyslipidemia: the Combined CODAM and Hoorn Studies

(2016) Nynke Simons et al.   DIABETES CARE

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

(2016) Cristian Pattaro et al.   Nature Communications

Analysis of a cardiovascular disease genetic risk score in the Diabetes Heart Study

(2015) Laura M. Raffield et al.   ACTA DIABETOLOGICA

Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes

(2015) Hirotaka Matsuo et al.   ANNALS OF THE RHEUMATIC DISEASES

Serum Uric Acid and Risk of CKD in Type 2 Diabetes

(2015) S. De Cosmo et al.   Clinical Journal of the American Society of Nephrology

The n-3 long-chain PUFAs modulate the impact of theGCKRPro446Leu polymorphism on triglycerides in adolescents

(2015) Julien Rousseaux et al.   JOURNAL OF LIPID RESEARCH

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

Early gene–diet interaction between glucokinase regulatory protein (GCKR) polymorphism, vegetable and fish intakes in modulating triglyceride levels in healthy adolescents

(2015) C.H.T. Tam et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Modulation of Glucokinase Regulatory Protein: A Double-Edged Sword?

(2015) Martijn C.G.J. Brouwers et al.   TRENDS IN MOLECULAR MEDICINE

Conducting Meta-Analyses inRwith themetaforPackage

(2015) Wolfgang Viechtbauer   Journal of Statistical Software

Rare mutations associating with serum creatinine and chronic kidney disease

(2014) Gardar Sveinbjornsson et al.   HUMAN MOLECULAR GENETICS

GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals: data from the J-MICC Study

(2014) Asahi Hishida et al.   JOURNAL OF NEPHROLOGY

Association of Non-alcoholic Fatty Liver Disease with Chronic Kidney Disease: A Systematic Review and Meta-analysis

(2014) Giovanni Musso et al.   PLOS MEDICINE

Investigation of known estimated glomerular filtration rate loci in patients with Type 2 diabetes

(2013) H. A. Deshmukh et al.   DIABETIC MEDICINE

Positive Association betweenGCKRrs780093 Polymorphism and Coronary Heart Disease in the Aged Han Chinese

(2013) Jiangfang Lian et al.   DISEASE MARKERS

Identification of chromosome 3q28 andALPK1as susceptibility loci for chronic kidney disease in Japanese individuals by a genome-wide association study

(2013) Yoshiji Yamada et al.   JOURNAL OF MEDICAL GENETICS

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

(2013) David J. Lloyd et al.   NATURE

Common variants associated with plasma triglycerides and risk for coronary artery disease

(2013) Ron Do et al.   NATURE GENETICS

Discovery of Piragliatin—First Glucokinase Activator Studied in Type 2 Diabetic Patients

(2012) Ramakanth Sarabu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations

(2012) Yukinori Okada et al.   NATURE GENETICS

Large-scale association analysis identifies new risk loci for coronary artery disease

(2012) Panos Deloukas et al.   NATURE GENETICS

Association of Genetic Variants Influencing Lipid Levels with Coronary Artery Disease in Japanese Individuals

(2012) Fumihiko Takeuchi et al.   PLoS One

Variants of GCKR Affect Both  -Cell and Kidney Function in Patients With Newly Diagnosed Type 2 Diabetes: The Verona Newly Diagnosed Type 2 Diabetes Study 2

(2011) S. Bonetti et al.   DIABETES CARE

Effects of MK-0941, a Novel Glucokinase Activator, on Glycemic Control in Insulin-Treated Patients With Type 2 Diabetes

(2011) G. E. Meininger et al.   DIABETES CARE

Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk

(2011) M. G. Rees et al.   DIABETOLOGIA

Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

(2011) Jeffrey A. Pfefferkorn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

(2011) John C Chambers et al.   NATURE GENETICS

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

(2011) Heribert Schunkert et al.   NATURE GENETICS

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

Glucokinase-activating GCKR Polymorphisms Increase Plasma Levels of Triglycerides and Free Fatty Acids, but do not Elevate Cardiovascular Risk in the Ludwigshafen Risk and Cardiovascular Health Study

(2010) D. H. Kozian et al.   HORMONE AND METABOLIC RESEARCH

New loci associated with kidney function and chronic kidney disease

(2010) Anna Köttgen et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Long-term renal changes in the liver-specific glucokinase knockout mouse: implications for renal disease in maturity-onset diabetes of the young 2

(2010) Yi Gu et al.   Translational Research

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

(2009) Nicola L. Beer et al.   HUMAN MOLECULAR GENETICS

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

(2009) Melanie Kolz et al.   PLoS Genetics

Glucokinase and molecular aspects of liver glycogen metabolism

(2008) Loranne Agius   BIOCHEMICAL JOURNAL

Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations

(2008) M. Orho-Melander et al.   DIABETES

Meta-analysis of skewed data: Combining results reported on log-transformed or raw scales

(2008) Julian P. T. Higgins et al.   STATISTICS IN MEDICINE