Anti-cancer activity of withaferin A in B-cell lymphoma

Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling

(2015) Shawn S. Jackson et al.   EXPERIMENTAL CELL RESEARCH

Effect of Withaferin A on A549 Cellular Proliferation and Apoptosis in Non-small Cell Lung Cancer

(2014) Yong Cai et al.   Asian Pacific Journal of Cancer Prevention

Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ

(2014) Karen Heyninck et al.   BIOCHEMICAL PHARMACOLOGY

Mechanistic Elucidation of the Antitumor Properties of Withaferin A in Breast Cancer

(2014) A. Nagalingam et al.   CANCER RESEARCH

Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis

(2014) Ravshan Burikhanov et al.   Nature Chemical Biology

Molecular Targets and Mechanisms of Cancer Prevention and Treatment by Withaferin A, A Naturally Occurring Steroidal Lactone

(2013) Avani R. Vyas et al.   AAPS Journal

Targeting pathological B cell receptor signalling in lymphoid malignancies

(2013) Ryan M. Young et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular insight in the multifunctional activities of Withaferin A

(2012) Wim Vanden Berghe et al.   BIOCHEMICAL PHARMACOLOGY

Novel Mechanism of Apoptosis Resistance in Cancer Mediated by Extracellular PAR-4

(2012) R. Burikhanov et al.   CANCER RESEARCH

Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies

(2012) Kian-Huat Lim et al.   IMMUNOLOGICAL REVIEWS

Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways

(2012) Patrick T. Grogan et al.   INVESTIGATIONAL NEW DRUGS

Withaferin A Synergizes the Therapeutic Effect of Doxorubicin through ROS-Mediated Autophagy in Ovarian Cancer

(2012) Miranda Y. Fong et al.   PLoS One

Natural withanolide withaferin A induces apoptosis in uveal melanoma cells by suppression of Akt and c-MET activation

(2012) Abbas K. Samadi et al.   TUMOR BIOLOGY

Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells

(2011) R. Munagala et al.   CARCINOGENESIS

Heat Shock Protein 90 Stabilizes Nucleolin to Increase mRNA Stability in Mitosis

(2011) Shao-An Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prostate Apoptosis Response 4 (Par-4), a Novel Substrate of Caspase-3 during Apoptosis Activation

(2011) P. Chaudhry et al.   MOLECULAR AND CELLULAR BIOLOGY

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

(2011) Kamalika Moulick et al.   Nature Chemical Biology

Prostate Apoptosis Response-4 Is Expressed in Normal Cholangiocytes, Is Down-Regulated in Human Cholangiocarcinoma, and Promotes Apoptosis of Neoplastic Cholangiocytes When Induced Pharmacologically

(2010) Antonio Franchitto et al.   AMERICAN JOURNAL OF PATHOLOGY

LXR-α genomics programmes neuronal death observed in Alzheimer’s disease

(2010) Ashvinder Raina et al.   APOPTOSIS

Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera’s key metabolite withaferin A

(2010) Abhinav Grover et al.   BMC GENOMICS

Anomalous constitutive Src kinase activity promotes B lymphoma survival and growth

(2010) Jiyuan Ke et al.   Molecular Cancer

Oncogenic Activation of NF- B

(2010) L. M. Staudt   Cold Spring Harbor Perspectives in Biology

Withaferin A targets heat shock protein 90 in pancreatic cancer cells

(2009) Yanke Yu et al.   BIOCHEMICAL PHARMACOLOGY

Withaferin A inhibits tumor necrosis factor-α-induced expression of cell adhesion molecules by inactivation of Akt and NF-κB in human pulmonary epithelial cells

(2009) Jung Hwa Oh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Natural compounds for cancer treatment and prevention

(2009) Stefania Nobili et al.   PHARMACOLOGICAL RESEARCH

Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade

(2008) Chandan Mandal et al.   APOPTOSIS

Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation

(2008) Jung Hwa Oh et al.   APOPTOSIS

Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia

(2008) L. Trentin et al.   BLOOD

Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations

(2008) J LOPICCOLO et al.   DRUG RESISTANCE UPDATES

Ayurvedic Medicine Constituent Withaferin A Causes G2 and M Phase Cell Cycle Arrest in Human Breast Cancer Cells

(2008) Silvia D. Stan et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL