Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells

A role for SUV39H1-mediated H3K9 trimethylation in the control of genome stability and senescence in WI38 human diploid lung fibroblasts

(2016) Corinne Sidler et al.   Aging-US

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Involvement of EZH2, SUV39H1, G9a and associated molecules in pathogenesis of urethane induced mouse lung tumors: Potential targets for cancer control

(2014) Manuraj Pandey et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Lung cancer epigenetics: emerging biomarkers

(2013) Ioanna Balgkouranidou et al.   Biomarkers in Medicine

Cancer-associated upregulation of histone H3 lysine 9 trimethylation promotes cell motilityin vitroand drives tumor formationin vivo

(2013) Yuhki Yokoyama et al.   CANCER SCIENCE

The chalcone 2′-hydroxy-4′,5′-dimethoxychalcone activates death receptor 5 pathway and leads to apoptosis in human nonsmall cell lung cancer cells

(2013) Lina Yang et al.   IUBMB LIFE

PKC  Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4-ATF3/CHOP Axis in Human Lung Cancer Cells

(2012) L. Xu et al.   MOLECULAR CANCER THERAPEUTICS

Death Receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells

(2011) Ling Su et al.   EUROPEAN JOURNAL OF CANCER

Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells

(2011) Guangbo Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Anti-leukemia activity of chaetocin via death receptor-dependent apoptosis and dual modulation of the histone methyl-transferase SUV39H1

(2011) H Chaib et al.   LEUKEMIA

Epigenetic Regulation of Surfactant Protein A Gene (SP-A) Expression in Fetal Lung Reveals a Critical Role for Suv39h Methyltransferases during Development and Hypoxia

(2011) H. Benlhabib et al.   MOLECULAR AND CELLULAR BIOLOGY

Modulation of death receptors by cancer therapeutic agents

(2010) Heath A. Elrod et al.   CANCER BIOLOGY & THERAPY

Antihepatoma activity of chaetocin due to deregulated splicing of hypoxia-inducible factor 1α pre-mRNA in mice and in vitro

(2010) Yoon-Mi Lee et al.   HEPATOLOGY

ERK/Ribosomal S6 Kinase (RSK) Signaling Positively Regulates Death Receptor 5 Expression through Co-activation of CHOP and Elk1

(2010) You-Take Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New insights into apoptosis signaling by Apo2L/TRAIL

(2010) F Gonzalvez et al.   ONCOGENE

A Novel Histone Deacetylase Inhibitor Exhibits Antitumor Activity via Apoptosis Induction, F-Actin Disruption and Gene Acetylation in Lung Cancer

(2010) Yen-An Tang et al.   PLoS One

Histone Deacetylase Inhibitors Downregulate Checkpoint Kinase 1 Expression to Induce Cell Death in Non-Small Cell Lung Cancer Cells

(2010) William Brazelle et al.   PLoS One

ATF3 transcription factor and its emerging roles in immunity and cancer

(2009) Matthew R. Thompson et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Anticancer Agent Chaetocin Is a Competitive Substrate and Inhibitor of Thioredoxin Reductase

(2008) Jennifer D. Tibodeau et al.   ANTIOXIDANTS & REDOX SIGNALING

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY