Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells

Deregulation of energy metabolism promotes antifibrotic effects in human hepatic stellate cells and prevents liver fibrosis in a mouse model

(2016) Swathi Karthikeyan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Melatonin: the dawning of a treatment for fibrosis?

(2016) Wei Hu et al.   JOURNAL OF PINEAL RESEARCH

Exosome Adherence and Internalization by Hepatic Stellate Cells Triggers Sphingosine 1-Phosphate-dependent Migration

(2015) Ruisi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin suppresses activation of hepatic stellate cells through RORα-mediated inhibition of 5-lipoxygenase

(2015) Shiva Shajari et al.   JOURNAL OF PINEAL RESEARCH

Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis

(2015) Beatriz San-Miguel et al.   JOURNAL OF PINEAL RESEARCH

Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells

(2015) Raquel Ordoñez et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

(2015) Anna Fernández et al.   JOURNAL OF PINEAL RESEARCH

Sphingosine-1-phosphate lyase is an endogenous suppressor of pulmonary fibrosis: role of S1P signalling and autophagy

(2015) Long Shuang Huang et al.   THORAX

Melatonin limits the expression of profibrogenic genes and ameliorates the progression of hepatic fibrosis in mice

(2015) Irene Crespo et al.   Translational Research

Drugging Sphingosine Kinases

(2014) Webster L. Santos et al.   ACS Chemical Biology

Cellular and molecular mechanisms in liver fibrogenesis

(2014) Erica Novo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

FTY720, a Sphingosine-1 Phosphate Receptor Modulator, Improves Liver Fibrosis in a Mouse Model by Impairing the Motility of Bone Marrow-Derived Mesenchymal Stem Cells

(2014) Yaxian Kong et al.   INFLAMMATION

Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway

(2013) Xing Wang et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells

(2013) S Carbajo-Pescador et al.   BRITISH JOURNAL OF CANCER

Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis

(2013) Le Yang et al.   JOURNAL OF HEPATOLOGY

Melatonin treatment reduces endoplasmic reticulum stress and modulates the unfolded protein response in rabbits with lethal fulminant hepatitis of viral origin

(2013) María J. Tuñón et al.   JOURNAL OF PINEAL RESEARCH

Bone Marrow-Derived Mesenchymal Stem Cells Differentiate to Hepatic Myofibroblasts by Transforming Growth Factor-β1 via Sphingosine Kinase/Sphingosine 1-Phosphate (S1P)/S1P Receptor Axis

(2012) Le Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Building a better sphingosine kinase-1 inhibitor

(2012) Kevin R. Lynch   BIOCHEMICAL JOURNAL

Sphingosine-1-phosphate as a mediator involved in development of fibrotic diseases

(2012) Yoh Takuwa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingosine-1-phosphate: A Janus-faced mediator of fibrotic diseases

(2012) Stephanie Schwalm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A review of the molecular aspects of melatonin’s anti-inflammatory actions: recent insights and new perspectives

(2012) José L. Mauriz et al.   JOURNAL OF PINEAL RESEARCH

Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway

(2012) Juan Huang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1α inactivation in hypoxic PC-3 prostate cancer cells

(2011) Sung-Yun Cho et al.   JOURNAL OF PINEAL RESEARCH

Acidic Sphingomyelinase Controls Hepatic Stellate Cell Activation and in Vivo Liver Fibrogenesis

(2010) Anna Moles et al.   AMERICAN JOURNAL OF PATHOLOGY

Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation

(2010) Xihong Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus

(2010) María J. Tuñón et al.   JOURNAL OF PINEAL RESEARCH

Transforming Growth Factor-β1 Induces Transdifferentiation of Myoblasts into Myofibroblasts via Up-Regulation of Sphingosine Kinase-1/S1P3 Axis

(2010) Francesca Cencetti et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of sphingosine kinase and sphingolipid signaling

(2010) Stuart M. Pitson   TRENDS IN BIOCHEMICAL SCIENCES

Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor- -stimulated collagen production by cardiac fibroblasts

(2009) N. Gellings Lowe et al.   CARDIOVASCULAR RESEARCH

Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis

(2009) Changyong Li et al.   JOURNAL OF HEPATOLOGY

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2

(2008) Hitoshi Ikeda et al.   JOURNAL OF LIPID RESEARCH