FTY720, a Sphingosine-1 Phosphate Receptor Modulator, Improves Liver Fibrosis in a Mouse Model by Impairing the Motility of Bone Marrow-Derived Mesenchymal Stem Cells

A Novel Immunomodulator, FTY-720 Reverses Existing Cardiac Hypertrophy and Fibrosis From Pressure Overload by Targeting NFAT (Nuclear Factor of Activated T-cells) Signaling and Periostin

(2013) Wei Liu et al.   Circulation-Heart Failure

Sphingosine 1-Phosphate (S1P) Receptor Agonists Mediate Pro-fibrotic Responses in Normal Human Lung Fibroblasts via S1P2and S1P3Receptors and Smad-independent Signaling

(2013) Katrin Sobel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FTY720 prevents progression of renal fibrosis by inhibiting renal microvasculature endothelial dysfunction in a rat model of chronic kidney disease

(2013) Haifeng Ni et al.   JOURNAL OF MOLECULAR HISTOLOGY

FTY720 attenuates tubulointerstitial inflammation and fibrosis in subtotally nephrectomized rats

(2013) Hai-Feng Ni et al.   RENAL FAILURE

Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection

(2012) Thamirys Guimarães Marques et al.   Acta Cirurgica Brasileira

Bone Marrow-Derived Mesenchymal Stem Cells Differentiate to Hepatic Myofibroblasts by Transforming Growth Factor-β1 via Sphingosine Kinase/Sphingosine 1-Phosphate (S1P)/S1P Receptor Axis

(2012) Le Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

FTY720 mediates activation suppression and G0/G1 cell cycle arrest in a concanavalin A-induced mouse lymphocyte pan-activation model

(2012) Xiangfeng Zeng et al.   INFLAMMATION RESEARCH

Transforming Growth Factor-β1 Induces Transdifferentiation of Myoblasts into Myofibroblasts via Up-Regulation of Sphingosine Kinase-1/S1P3 Axis

(2010) Francesca Cencetti et al.   MOLECULAR BIOLOGY OF THE CELL

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Fingolimod is a potential novel therapy for multiple sclerosis

(2010) Orhan Aktas et al.   Nature Reviews Neurology

Involvement of Sphingosine 1-Phosphate (SIP)/S1P 3 Signaling in Cholestasis-Induced Liver Fibrosis

(2009) Changyong Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor- -stimulated collagen production by cardiac fibroblasts

(2009) N. Gellings Lowe et al.   CARDIOVASCULAR RESEARCH

Negligible Contribution of Bone Marrow-Derived Cells to Collagen Production During Hepatic Fibrogenesis in Mice

(2009) Reiichi Higashiyama et al.   GASTROENTEROLOGY

Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis

(2009) Changyong Li et al.   JOURNAL OF HEPATOLOGY

TGFβ protects mesoangioblasts from apoptosis via sphingosine kinase-1 regulation

(2008) Chiara Donati et al.   CELLULAR SIGNALLING

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Thematic Review Series: Sphingolipids.Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling,

(2008) Deborah A. Lebman et al.   JOURNAL OF LIPID RESEARCH

Sphingosine Kinases and Sphingosine-1-Phosphate Are Critical for Transforming Growth Factor  -Induced Extracellular Signal-Regulated Kinase 1 and 2 Activation and Promotion of Migration and Invasion of Esophageal Cancer Cells

(2008) A. V. Miller et al.   MOLECULAR AND CELLULAR BIOLOGY