Late-Stage Functionalization of Histidine in Unprotected Peptides

Contemporary approaches to site-selective protein modification

(2019) Emily A. Hoyt et al.   Nature Reviews Chemistry

Site-Selective δ-C(sp3 )−H Alkylation of Amino Acids and Peptides with Maleimides via a Six-Membered Palladacycle

(2018) Bei-Bei Zhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Late-Stage Peptide Diversification by Position-Selective C-H Activation

(2018) Wei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

On the design principles of peptide–drug conjugates for targeted drug delivery to the malignant tumor site

(2018) Eirinaios I Vrettos et al.   Beilstein Journal of Organic Chemistry

Therapeutic peptides: Historical perspectives, current development trends, and future directions

(2018) Jolene L. Lau et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Late-Stage Functionalization of Drug-Like Molecules Using Diversinates

(2018) Christian A. Kuttruff et al.   ChemMedChem

Peptide modification and cyclization via transition-metal catalysis

(2018) Lara R Malins   CURRENT OPINION IN CHEMICAL BIOLOGY

Site-selective C-H Bond Activation/Functionalization on Alpha-Amino Acids and Peptide-like Derivatives

(2018) Tobias Brandhofer et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Selective Radical Trifluoromethylation of Native Residues in Proteins

(2018) Mateusz Imiołek et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engaging sulfinate salts via Ni/photoredox dual catalysis enables facile Csp2–SO2R coupling

(2018) María Jesús Cabrera-Afonso et al.   Chemical Science

Protecting group free radical C–H trifluoromethylation of peptides

(2018) Naoko Ichiishi et al.   Chemical Science

Late-Stage Peptide Diversification through Cobalt-Catalyzed C−H Activation: Sequential Multicatalysis for Stapled Peptides

(2018) Mélanie M. Lorion et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alkyl Sulfinates: Radical Precursors Enabling Drug Discovery

(2018) Joel M. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Current State of Peptide Drug Discovery: Back to the Future?

(2017) Antoine Henninot et al.   JOURNAL OF MEDICINAL CHEMISTRY

Late stage modification of peptides via C H activation reactions

(2017) Saumitra Sengupta et al.   TETRAHEDRON LETTERS

Mild and Regioselective Pd(OAc)2-Catalyzed C–H Arylation of Tryptophans by [ArN2]X, Promoted by Tosic Acid

(2017) Alan J. Reay et al.   ACS Catalysis

Stapled Peptides by Late-Stage C(sp3 )−H Activation

(2016) Anaïs F. M. Noisier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

(2016) Tim Cernak et al.   CHEMICAL SOCIETY REVIEWS

Oral Administration of Peptide-Based Drugs: Beyond Lipinski's Rule

(2016) Gabriela B. Santos et al.   ChemMedChem

Radicals: Reactive Intermediates with Translational Potential

(2016) Ming Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Review cyclic peptides on a merry-go-round; towards drug design

(2015) Anthi Tapeinou et al.   BIOPOLYMERS

Advances in Chemical Protein Modification

(2015) Omar Boutureira et al.   CHEMICAL REVIEWS

Late-Stage Peptide Diversification by Bioorthogonal Catalytic CH Arylation at 23 °C in H2O

(2015) Yingjun Zhu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chemo- and Regioselective Ethynylation of Tryptophan-Containing Peptides and Proteins

(2015) Morten Borre Hansen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Unified mild reaction conditions for C2-selective Pd-catalysed tryptophan arylation, including tryptophan-containing peptides

(2015) Alan J. Reay et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

New peptide architectures through C–H activation stapling between tryptophan–phenylalanine/tyrosine residues

(2015) Lorena Mendive-Tapia et al.   Nature Communications

Radical CH Functionalization of Heteroarenes under Electrochemical Control

(2014) Alexander G. O'Brien et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Targeting of Rab-GTPase-Effector Interactions

(2014) Jochen Spiegel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Simple Sulfinate Synthesis Enables CH Trifluoromethylcyclopropanation

(2014) Ryan Gianatassio et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C–H Functionalization in the Synthesis of Amino Acids and Peptides

(2014) Anaïs F. M. Noisier et al.   CHEMICAL REVIEWS

Late-Stage Diversification of Peptides by Metal-Free CH Arylation

(2014) Yingjun Zhu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Site-Selective C(sp3)–H Functionalization of Di-, Tri-, and Tetrapeptides at the N-Terminus

(2014) Wei Gong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Synthesis of Fluorinated Heteroarylether Bioisosteres

(2013) Qianghui Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The multiple roles of histidine in protein interactions

(2013) Si-Ming Liao et al.   Chemistry Central Journal

Bioconjugation by Native Chemical Tagging of C–H Bonds

(2013) Qianghui Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical-Based Regioselective C–H Functionalization of Electron-Deficient Heteroarenes: Scope, Tunability, and Predictability

(2013) Fionn O’Hara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Innate C-H trifluoromethylation of heterocycles

(2011) Y. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic potential of neuropeptide Y (NPY) receptor ligands

(2010) Shaun P. Brothers et al.   EMBO Molecular Medicine

Postsynthetic Modification of Peptides: Chemoselective C-Arylation of Tryptophan Residues

(2009) Javier Ruiz-Rodríguez et al.   CHEMISTRY-A EUROPEAN JOURNAL

Eleven Amino Acid Glucagon-like Peptide-1 Receptor Agonists with Antidiabetic Activity

(2009) Claudio Mapelli et al.   JOURNAL OF MEDICINAL CHEMISTRY