High-Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates

Acetonitrile Activation: An Effective Two-Carbon Unit for Cyclization

(2019) Qixue Qin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Synthesis of Cyclobutenes from Alkynes and Alkenyl Derivatives

(2019) Mahesh M. Parsutkar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Synthesis of Boryl-Functionalized Cyclobutanols

(2019) Andrew Whyte et al.   ACS Catalysis

A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flow

(2018) Damith Perera et al.   SCIENCE

Catalytic approaches to assemble cyclobutane motifs in natural product synthesis

(2018) Meng Wang et al.   Organic Chemistry Frontiers

Asymmetric Synthesis of Cyclobutanone via Lewis Acid Catalyzed Tandem Cyclopropanation/Semipinacol Rearrangement

(2018) Su Yong Shim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carbopalladation of C–C σ-bonds enabled by strained boronate complexes

(2018) Alexander Fawcett et al.   Nature Chemistry

Pd(II)-Catalyzed Enantioselective C(sp3)–H Borylation

(2017) Jian He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cobalt Catalysis for Enantioselective Cyclobutanone Construction

(2017) Daniel K. Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cyclopropyl- and Cyclobutylboronates and -silanes: A Stereo­selective Approach

(2017) Mariola Tortosa et al.   SYNTHESIS-STUTTGART

Enantioselective Synthesis of Cyclobutylboronates via a Copper-Catalyzed Desymmetrization Approach

(2016) Manuel Guisán-Ceinos et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantiospecific Alkynylation of Alkylboronic Esters

(2016) Yahui Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cyclobutenones and Benzocyclobutenones: Versatile Synthons in Organic Synthesis

(2016) Peng-hao Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Synthesis of α-Methyl-β-cyclopropyldihydrocinnamates

(2016) Melodie Christensen et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and Biopharmaceutical Evaluation of Imatinib Analogues Featuring Unusual Structural Motifs

(2015) Kyriacos C. Nicolaou et al.   ChemMedChem

Access to functionalized 3-amino-benzothiophenes using keteniminium intermediates

(2015) Alexandre Lumbroso et al.   TETRAHEDRON LETTERS

Enantioselective Synthesis of Boron-Substituted Quaternary Carbon Stereogenic Centers through NHC-Catalyzed Conjugate Additions of (Pinacolato)boron Units to Enones

(2014) Suttipol Radomkit et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Naturally occurring bioactive Cyclobutane-containing (CBC) alkaloids in fungi, fungal endophytes, and plants

(2014) Valery M. Dembitsky   PHYTOMEDICINE

Enantioselective Intermolecular [2+2] Photocycloadditions of Isoquinolone Mediated by a Chiral Hydrogen-Bonding Template

(2013) Susannah C. Coote et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

(2012) Antonia F. Stepan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rhodium-Catalyzed and Zinc(II)-Triflate-Promoted Asymmetric Hydrogenation of Tetrasubstituted α,β-Unsaturated Ketones

(2012) Joel R. Calvin et al.   ORGANIC LETTERS

Enantioselective Construction of Quaternary Stereogenic Centers from Tertiary Boronic Esters: Methodology and Applications

(2011) Ravindra P. Sonawane et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Methylation Effect in Medicinal Chemistry

(2011) Eliezer J. Barreiro et al.   CHEMICAL REVIEWS

Discovery of Two Clinical Histamine H3Receptor Antagonists:trans-N-Ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) andtrans-3-Fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764)

(2011) Travis T. Wager et al.   JOURNAL OF MEDICINAL CHEMISTRY

Complete Stereoretention in the Rhodium-Catalyzed 1,2-Addition of Chiral Secondary and Tertiary Alkyl Potassium Trifluoroborate Salts to Aldehydes

(2009) Abel Ros et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic enantioselective boron conjugate addition to cyclic carbonyl compounds: a new approach to cyclic β-hydroxy carbonyls

(2009) Xinhui Feng et al.   CHEMICAL COMMUNICATIONS

Catalytic Asymmetric Synthesis of Chiral Tertiary Organoboronic Esters through Conjugate Boration of β-Substituted Cyclic Enones

(2009) I-Hon Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY