Mutations in the sonic hedgehog pathway cause macrocephaly‐associated conditions due to crosstalk to the PI3K/AKT/mTOR pathway

Crosstalk between Notch and Sonic hedgehog signaling in a mouse model of amyotrophic lateral sclerosis

(2017) Xiaoxing Ma et al.   NEUROREPORT

Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells

(2017) Yoshikazu Koike et al.   Breast Cancer

A Recurrent Mosaic Mutation in SMO , Encoding the Hedgehog Signal Transducer Smoothened, Is the Major Cause of Curry-Jones Syndrome

(2016) Stephen R.F. Twigg et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways

(2016) Tilman Borggrefe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hedgehog signalling

(2016) Raymond Teck Ho Lee et al.   DEVELOPMENT

Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer

(2016) Zhaohui Yang et al.   Disease Models & Mechanisms

Association of chloride intracellular channel 4 and Indian hedgehog proteins with survival of patients with pancreatic ductal adenocarcinoma

(2016) Qiong Zou et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition

(2016) Yumi Miyazaki et al.   Molecular Cancer

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Translating Hedgehog in Cancer: Controlling Protein Synthesis

(2016) Davide D’Amico et al.   TRENDS IN MOLECULAR MEDICINE

DYRK1B blocks canonical and promotes non-canonical Hedgehog signaling through activation of the mTOR/AKT pathway

(2016) Rajeev Singh et al.   Oncotarget

Crosstalk between SHH and stemness state signaling pathways in esophageal squamous cell carcinoma

(2016) Maryam Najafi et al.   Journal of Cell Communication and Signaling

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

(2016) Tadas Rimkus et al.   Cancers

A familial 7q36.3 duplication associated with agenesis of the corpus callosum

(2015) Keith Wong et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcoma

(2015) Ulrike Graab et al.   Oncotarget

PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth

(2015) Narinder Sharma et al.   Oncotarget

Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ

(2015) Rie Sonamoto et al.   Scientific Reports

The Hedgehog Signalling Pathway in Cell Migration and Guidance: What We Have Learned from Drosophila melanogaster

(2015) Sofia Araújo   Cancers

Wing tips: The wing disc as a platform for studying Hedgehog signaling

(2014) Tom A. Hartl et al.   METHODS

Reconstruction of the Gene Regulatory Network Involved in the Sonic Hedgehog Pathway with a Potential Role in Early Development of the Mouse Brain

(2014) Jinhua Liu et al.   PLoS Computational Biology

RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells

(2013) Bradley S. Gordon et al.   CELLULAR SIGNALLING

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities

(2013) Mariella Gruber Filbin et al.   NATURE MEDICINE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

The Crosstalk of mTOR/S6K1 and Hedgehog Pathways

(2012) Yan Wang et al.   CANCER CELL

A large duplication involving the IHH locus mimics acrocallosal syndrome

(2012) Memnune Yuksel-Apak et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A mutation in KIF7 is responsible for the autosomal recessive syndrome of macrocephaly, multiple epiphyseal dysplasia and distinctive facial appearance

(2012) Bassam R Ali et al.   Orphanet Journal of Rare Diseases

Review: Targeting the Hedgehog pathway in cancer

(2010) Sachin Gupta et al.   Therapeutic Advances in Medical Oncology

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

(2008) E. Dessaud et al.   DEVELOPMENT

PTCH1 duplication in a family with microcephaly and mild developmental delay

(2008) Katarzyna Derwińska et al.   EUROPEAN JOURNAL OF HUMAN GENETICS