Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin

L1 drives IFN in senescent cells and promotes age-associated inflammation

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Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

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Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options

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In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

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Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

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Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

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The Cockayne Syndrome Natural History (CoSyNH) study: clinical findings in 102 individuals and recommendations for care

(2015) Brian T. Wilson et al.   GENETICS IN MEDICINE

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells

(2015) Michael C. Velarde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants – past, present and future

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Senescence and apoptosis: dueling or complementary cell fates?

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IFN- -Induced TNF-  Expression Is Regulated by Interferon Regulatory Factors 1 and 8 in Mouse Macrophages

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Involvement of ERCC1 in the pathogenesis of osteoarthritis through the modulation of apoptosis and cellular senescence

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Understanding nucleotide excision repair and its roles in cancer and ageing

(2014) Jurgen A. Marteijn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Age-related dystrophic changes in corneal endothelium from DNA repair-deficient mice

(2013) Danny S. Roh et al.   AGING CELL

DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria

(2013) Ismene Karakasilioti et al.   Cell Metabolism

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

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Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism

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NF-κB inhibition delays DNA damage–induced senescence and aging in mice

(2012) Jeremy S. Tilstra et al.   JOURNAL OF CLINICAL INVESTIGATION

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Physiological consequences of defects in ERCC1–XPF DNA repair endonuclease

(2011) Siobhán Q. Gregg et al.   DNA REPAIR

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

The essence of senescence

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

TNF-α Impairs the S-G2/M Cell Cycle Checkpoint and Cyclobutane Pyrimidine Dimer Repair in Premalignant Skin Cells: Role of the PI3K–Akt Pathway

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