pH/ATP cascade-responsive nano-courier with efficient tumor targeting and siRNA unloading for photothermal-immunotherapy

Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy

(2019) Quan Zhou et al.   Nature Nanotechnology

Rekindling RNAi Therapy: Materials Design Requirements for In Vivo siRNA Delivery

(2019) Byungji Kim et al.   ADVANCED MATERIALS

Activating Antitumor Immunity and Antimetastatic Effect Through Polydopamine‐Encapsulated Core–Shell Upconversion Nanoparticles

(2019) Shuangqian Yan et al.   ADVANCED MATERIALS

Tumor‐Targeted Drug and CpG Delivery System for Phototherapy and Docetaxel‐Enhanced Immunotherapy with Polarization toward M1‐Type Macrophages on Triple Negative Breast Cancers

(2019) Lv Chen et al.   ADVANCED MATERIALS

Enhanced Tumor Retention Effect by Click Chemistry for Improved Cancer Immunochemotherapy

(2018) Ling Mei et al.   ACS Applied Materials & Interfaces

Size/Charge Changeable Acidity-Responsive Micelleplex for Photodynamic-Improved PD-L1 Immunotherapy with Enhanced Tumor Penetration

(2018) Liangliang Dai et al.   ADVANCED FUNCTIONAL MATERIALS

Near-Infrared-Light-Activatable Nanomaterial-Mediated Phototheranostic Nanomedicines: An Emerging Paradigm for Cancer Treatment

(2018) Raviraj Vankayala et al.   ADVANCED MATERIALS

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer

(2018) Jutaek Nam et al.   Nature Communications

Charge and Assembly Reversible Micelles Fueled by Intracellular ATP for Improved siRNA Transfection

(2018) Zhanwei Zhou et al.   ACS Applied Materials & Interfaces

A size-shrinkable nanoparticle-based combined anti-tumor and anti-inflammatory strategy for enhanced cancer therapy

(2018) Zhengze Lu et al.   Nanoscale

ATP-activated decrosslinking and charge-reversal vectors for siRNA delivery and cancer therapy

(2018) Zhanwei Zhou et al.   Theranostics

Palmitoylation stabilizes PD-L1 to promote breast tumor growth

(2018) Yi Yang et al.   CELL RESEARCH

PD-L1 knockdown via hybrid micelle promotes paclitaxel induced Cancer-Immunity Cycle for melanoma treatment

(2018) Xian Tang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

(2017) Jinfang Zhang et al.   NATURE

Systemic siRNA Delivery with a Dual pH-Responsive and Tumor-targeted Nanovector for Inhibiting Tumor Growth and Spontaneous Metastasis in Orthotopic Murine Model of Breast Carcinoma

(2017) Bo Fan et al.   Theranostics

Tumor-Microenvironment-Adaptive Nanoparticles Codeliver Paclitaxel and siRNA to Inhibit Growth and Lung Metastasis of Breast Cancer

(2016) Shan Tang et al.   ADVANCED FUNCTIONAL MATERIALS

Phenylboronic acid-sugar grafted polymer architecture as a dual stimuli-responsive gene carrier for targeted anti-angiogenic tumor therapy

(2016) Jinhwan Kim et al.   BIOMATERIALS

Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy

(2016) Xiaodong Zhang et al.   International Journal of Nanomedicine

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

(2016) Chia-Wei Li et al.   Nature Communications

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy

(2016) Qian Chen et al.   Nature Communications

Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (β-amino ester) nanoparticles co-delivering two siRNA and paclitaxel

(2015) Shan Tang et al.   BIOMATERIALS

Tumor Acidity-Sensitive Polymeric Vector for Active Targeted siRNA Delivery

(2015) Chun-Yang Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Live cell imaging of duplex siRNA intracellular trafficking

(2015) Markus Hirsch et al.   NUCLEIC ACIDS RESEARCH

A Reduction and pH Dual-Sensitive Polymeric Vector for Long-Circulating and Tumor-Targeted siRNA Delivery

(2014) Jingguo Li et al.   ADVANCED MATERIALS

Paclitaxel loaded liposomes decorated with a multifunctional tandem peptide for glioma targeting

(2014) Yayuan Liu et al.   BIOMATERIALS

Progress of drug-loaded polymeric micelles into clinical studies

(2014) Horacio Cabral et al.   JOURNAL OF CONTROLLED RELEASE

ATP-triggered anticancer drug delivery

(2014) Ran Mo et al.   Nature Communications

Phenylboronic Acid-Installed Polymeric Micelles for Targeting Sialylated Epitopes in Solid Tumors

(2013) Stephanie Deshayes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biomolecular robotics for chemomechanically driven guest delivery fuelled by intracellular ATP

(2013) Shuvendu Biswas et al.   Nature Chemistry

Near-Infrared Light-Responsive Intracellular Drug and siRNA Release Using Au Nanoensembles with Oligonucleotide-Capped Silica Shell

(2012) Yi-Ting Chang et al.   ADVANCED MATERIALS

The Two Faces of Interferon-  in Cancer

(2011) M. R. Zaidi et al.   CLINICAL CANCER RESEARCH

Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles

(2010) Chunbai He et al.   BIOMATERIALS

Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles

(2008) Frank Alexis et al.   MOLECULAR PHARMACEUTICS