Metabolic Reprogramming by Dual-targeting Biomimetic Nanoparticles for Enhanced Tumor Chemo-Immunotherapy

Targeting metastatic cancer

(2021) Karuna Ganesh et al.   NATURE MEDICINE

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

(2021) McLane J. Watson et al.   NATURE

Nano-delivery systems focused on tumor microenvironment regulation and biomimetic strategies for treatment of breast cancer metastasis

(2021) Xiaoyan Gu et al.   JOURNAL OF CONTROLLED RELEASE

Genetically Programmable Fusion Cellular Vesicles for Cancer Immunotherapy

(2021) Qian‐Fang Meng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

(2021) Xiaoqi Mao et al.   Molecular Cancer

Ginsenosides emerging as both bifunctional drugs and nanocarriers for enhanced antitumor therapies

(2021) Hong Wang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Targeting cancer-associated fibroblasts by dual-responsive lipid-albumin nanoparticles to enhance drug perfusion for pancreatic tumor therapy

(2020) Qianwen Yu et al.   JOURNAL OF CONTROLLED RELEASE

Metabolic reprogramming and cancer progression

(2020) Brandon Faubert et al.   SCIENCE

Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy

(2020) Chunai Gong et al.   JOURNAL OF NANOBIOTECHNOLOGY

Bacterial Vesicle-Cancer Cell Hybrid Membrane-Coated Nanoparticles for Tumor Specific Immune Activation and Photothermal Therapy

(2020) Dongdong Wang et al.   ACS Applied Materials & Interfaces

Engineering of Cascade-Responsive Nanoplatform to Inhibit Lactate Efflux for Enhanced Tumor Chemo-Immunotherapy

(2020) Ke Li et al.   ACS Nano

Power of two: Combination of therapeutic approaches involving glucose transporter (GLUT) inhibitors to combat cancer

(2020) Kalpana Tilekar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

PFKFB3 inhibitors as potential anticancer agents: Mechanisms of action, current developments, and structure-activity relationships

(2020) Yinhu Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis

(2020) Lang Rao et al.   Nature Communications

Cancer Stem Cell-Platelet Hybrid Membrane-Coated Magnetic Nanoparticles for Enhanced Photothermal Therapy of Head and Neck Squamous Cell Carcinoma

(2019) Lin-Lin Bu et al.   ADVANCED FUNCTIONAL MATERIALS

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Intratumoral Heterogeneity: More Than Just Mutations

(2019) Kunihiko Hinohara et al.   TRENDS IN CELL BIOLOGY

Intra/Extracellular Lactic Acid Exhaustion for Synergistic Metabolic Therapy and Immunotherapy of Tumors

(2019) Fan Gao et al.   ADVANCED MATERIALS

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Erythrocyte–Cancer Hybrid Membrane Camouflaged Hollow Copper Sulfide Nanoparticles for Prolonged Circulation Life and Homotypic-Targeting Photothermal/Chemotherapy of Melanoma

(2018) Dongdong Wang et al.   ACS Nano

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

Metabolic Symbiosis and Immunomodulation: How Tumor Cell-Derived Lactate May Disturb Innate and Adaptive Immune Responses

(2018) Alexandre Morrot et al.   Frontiers in Oncology

Cell Membrane Coated Semiconducting Polymer Nanoparticles for Enhanced Multimodal Cancer Phototheranostics

(2018) Jingchao Li et al.   ACS Nano

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Lactate: A Metabolic Driver in the Tumour Landscape

(2018) Luigi Ippolito et al.   TRENDS IN BIOCHEMICAL SCIENCES

Optimized biodegradable polymeric reservoir-mediated local and sustained co-delivery of dendritic cells and oncolytic adenovirus co-expressing IL-12 and GM-CSF for cancer immunotherapy

(2017) Eonju Oh et al.   JOURNAL OF CONTROLLED RELEASE

Protein Nanocage Mediated Fibroblast-Activation Protein Targeted Photoimmunotherapy To Enhance Cytotoxic T Cell Infiltration and Tumor Control

(2017) Zipeng Zhen et al.   NANO LETTERS

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Metabolic Interactions in the Tumor Microenvironment

(2017) Costas A. Lyssiotis et al.   TRENDS IN CELL BIOLOGY

The reverse Warburg effect is likely to be an Achilles’ heel of cancer that can be exploited for cancer therapy

(2017) Yaojie Fu et al.   Oncotarget

The Binding Site Barrier Elicited by Tumor-Associated Fibroblasts Interferes Disposition of Nanoparticles in Stroma-Vessel Type Tumors

(2016) Lei Miao et al.   ACS Nano

Cancer-Cell-Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors

(2016) Huiping Sun et al.   ADVANCED MATERIALS

Preferential Cancer Cell Self-Recognition and Tumor Self-Targeting by Coating Nanoparticles with Homotypic Cancer Cell Membranes

(2016) Jing-Yi Zhu et al.   NANO LETTERS

Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy

(2016) Laura Pisarsky et al.   Cell Reports

Breast Cancer-Associated Fibroblasts: Where We Are and Where We Need to Go

(2016) Rachel Buchsbaum et al.   Cancers

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

(2014) Ronnie H. Fang et al.   NANO LETTERS

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

(2014) Ubaldo E. Martinez-Outschoorn et al.   SEMINARS IN CANCER BIOLOGY

Tumor glycolysis as a target for cancer therapy: progress and prospects

(2013) Shanmugasundaram Ganapathy-Kanniappan et al.   Molecular Cancer

Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay

(2012) T. Fiaschi et al.   CANCER RESEARCH

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

(2010) Ming Zhou et al.   Molecular Cancer

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE