A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging

Nano-palladium is a cellular catalyst for in vivo chemistry

(2017) Miles A. Miller et al.   Nature Communications

Improved Deconvolution of Protein Targets for Bioactive Compounds Using a Palladium Cleavable Chloroalkane Capture Tag

(2016) Rachel Friedman Ohana et al.   ACS Chemical Biology

Palladium-Triggered Chemical Rescue of Intracellular Proteins via Genetically Encoded Allene-Caged Tyrosine

(2016) Jie Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development and application of bond cleavage reactions in bioorthogonal chemistry

(2016) Jie Li et al.   Nature Chemical Biology

Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

(2016) Barbara Bernardim et al.   Nature Communications

Transition-metal-mediated uncaging in living human cells—an emerging alternative to photolabile protecting groups

(2015) Timo Völker et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Organometallic palladium reagents for cysteine bioconjugation

(2015) Ekaterina V. Vinogradova et al.   NATURE

Palladium: a future key player in the nanomedical field?

(2015) Anaëlle Dumas et al.   Chemical Science

Transition metal-catalyzed C–H bond functionalizations by the use of diverse directing groups

(2015) Zhengkai Chen et al.   Organic Chemistry Frontiers

Palladium-Mediated Dealkylation of N-Propargyl-Floxuridine as a Bioorthogonal Oxygen-Independent Prodrug Strategy

(2015) Jason T. Weiss et al.   Scientific Reports

Progress towards Bioorthogonal Catalysis with Organometallic Compounds

(2014) Timo Völker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ado-trastuzumab Emtansine (T-DM1): An Antibody–Drug Conjugate (ADC) for HER2-Positive Breast Cancer

(2014) John M. Lambert et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development and Bioorthogonal Activation of Palladium-Labile Prodrugs of Gemcitabine

(2014) Jason T. Weiss et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genetic Encoding of Photocaged Cysteine Allows Photoactivation of TEV Protease in Live Mammalian Cells

(2014) Duy P. Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diels-Alder reaction–triggered bioorthogonal protein decaging in living cells

(2014) Jie Li et al.   Nature Chemical Biology

Palladium-triggered deprotection chemistry for protein activation in living cells

(2014) Jie Li et al.   Nature Chemistry

Click to Release: Instantaneous Doxorubicin Elimination upon Tetrazine Ligation

(2013) Ron M. Versteegen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed C–H Alkenylation of Arenes Using Thioethers as Directing Groups

(2012) Ming Yu et al.   ORGANIC LETTERS

A Traceless Vascular-Targeting Antibody-Drug Conjugate for Cancer Therapy

(2011) Gonçalo J. L. Bernardes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-mediated site-selective Suzuki–Miyaura protein modification at genetically encoded aryl halides

(2011) Christopher D. Spicer et al.   CHEMICAL COMMUNICATIONS

Preclinical screening of anti-HER2 nanobodies for molecular imaging of breast cancer

(2011) Ilse Vaneycken et al.   FASEB JOURNAL

Sulfur-Directed Olefin Oxidations: Observation of Divergent Reaction Mechanisms in the Palladium-Mediated Acetoxylation of Unsaturated Thioacetals

(2011) Sam E. Mann et al.   ORGANOMETALLICS

A Highly Efficient, Practical, and General Route for the Synthesis of (R3P)2Pd(0): Structural Evidence on the Reduction Mechanism of Pd(II) to Pd(0)

(2010) Hongbo Li et al.   ORGANIC LETTERS

Illuminating the Chemistry of Life: Design, Synthesis, and Applications of “Caged” and Related Photoresponsive Compounds

(2009) Hsien-Ming Lee et al.   ACS Chemical Biology

Allyl Sulfides Are Privileged Substrates in Aqueous Cross-Metathesis: Application to Site-Selective Protein Modification

(2008) Yuya A. Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mitochondria-Targeted Chemotherapeutics: The Rational Design of Gold(I)N-Heterocyclic Carbene Complexes That Are Selectively Toxic to Cancer Cells and Target Protein Selenols in Preference to Thiols

(2008) James L. Hickey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY