Engineering patient-specific cancer immunotherapies

Cancer nanomedicine for combination cancer immunotherapy

(2019) Jutaek Nam et al.   Nature Reviews Materials

Subcutaneous Nanodisc Vaccination with Neoantigens for Combination Cancer Immunotherapy

(2018) Rui Kuai et al.   BIOCONJUGATE CHEMISTRY

Macromolecule nanotherapeutics: approaches and challenges

(2018) Puneet Tyagi et al.   DRUG DISCOVERY TODAY

Dual TLR agonist nanodiscs as a strong adjuvant system for vaccines and immunotherapy

(2018) Rui Kuai et al.   JOURNAL OF CONTROLLED RELEASE

Separating T Cell Targeting Components onto Magnetically Clustered Nanoparticles Boosts Activation

(2018) Alyssa K. Kosmides et al.   NANO LETTERS

Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells

(2018) Alexander S Cheung et al.   NATURE BIOTECHNOLOGY

Material aid for vaccines

(2018) Darrell Irvine   NATURE MATERIALS

A facile approach to enhance antigen response for personalized cancer vaccination

(2018) Aileen Weiwei Li et al.   NATURE MATERIALS

EVIR: chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens

(2018) Mario Leonardo Squadrito et al.   NATURE METHODS

Personalized vaccines for cancer immunotherapy

(2018) Ugur Sahin et al.   SCIENCE

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer

(2018) Janos L. Tanyi et al.   Science Translational Medicine

Structural absorption by barbule microstructures of super black bird of paradise feathers

(2018) Dakota E. McCoy et al.   Nature Communications

An Albumin-binding Polypeptide Both Targets Cytotoxic T Lymphocyte Vaccines to Lymph Nodes and Boosts Vaccine Presentation by Dendritic Cells

(2018) Peng Wang et al.   Theranostics

Injectable, Tough Alginate Cryogels as Cancer Vaccines

(2018) Ting-Yu Shih et al.   Advanced Healthcare Materials

Elimination of established tumors with nanodisc-based combination chemoimmunotherapy

(2018) Rui Kuai et al.   Science Advances

Low-dose X-ray radiotherapy–radiodynamic therapy via nanoscale metal–organic frameworks enhances checkpoint blockade immunotherapy

(2018) Kuangda Lu et al.   Nature Biomedical Engineering

Actively personalized vaccination trial for newly diagnosed glioblastoma

(2018) Norbert Hilf et al.   NATURE

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

(2018) Derin B. Keskin et al.   NATURE

Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors

(2017) Tyrel T. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound

(2017) Kelsie F Timbie et al.   JOURNAL OF CONTROLLED RELEASE

Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy

(2017) Zinal S. Chheda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers

(2017) Tyrel T. Smith et al.   Nature Nanotechnology

A STING-activating nanovaccine for cancer immunotherapy

(2017) Min Luo et al.   Nature Nanotechnology

Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy

(2017) Yuanzeng Min et al.   Nature Nanotechnology

18F-FDG PET/CT-based early treatment response evaluation of nanoparticle-assisted photothermal cancer therapy

(2017) Kamilla Norregaard et al.   PLoS One

Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors

(2017) Viktor A. Adalsteinsson et al.   Nature Communications

In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma

(2017) Martin Lauss et al.   Nature Communications

Spatial Control of Gene Expression by Nanocarriers Using Heparin Masking and Ultrasound-Targeted Microbubble Destruction

(2016) Beata Chertok et al.   ACS Nano

High-Density Lipoproteins: Nature’s Multifunctional Nanoparticles

(2016) Rui Kuai et al.   ACS Nano

Targeting dendritic cells in lymph node with an antigen peptide-based nanovaccine for cancer immunotherapy

(2016) Yuan Qian et al.   BIOMATERIALS

Folate-conjugated gene-carrying microbubbles with focused ultrasound for concurrent blood-brain barrier opening and local gene delivery

(2016) Ching-Hsiang Fan et al.   BIOMATERIALS

Immune-related adverse events with immune checkpoint blockade: a comprehensive review

(2016) J.M. Michot et al.   EUROPEAN JOURNAL OF CANCER

Dendritic cell–derived exosomes for cancer therapy

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound

(2016) Brian P. Mead et al.   JOURNAL OF CONTROLLED RELEASE

Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

(2016) Jonathan E Rosenberg et al.   LANCET

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Designer vaccine nanodiscs for personalized cancer immunotherapy

(2016) Rui Kuai et al.   NATURE MATERIALS

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

(2016) Alena Gros et al.   NATURE MEDICINE

Systemic activation of antigen-presenting cells via RNA-loaded nanoparticles

(2016) Elias J. Sayour et al.   OncoImmunology

Designing hydrogels for controlled drug delivery

(2016) Jianyu Li et al.   Nature Reviews Materials

The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant

(2015) Kobe Reynders et al.   CANCER TREATMENT REVIEWS

Synthetic Nanoparticles for Vaccines and Immunotherapy

(2015) Darrell J. Irvine et al.   CHEMICAL REVIEWS

Immunogenic peptide discovery in cancer genomes

(2015) Alexandra Snyder et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Gene delivery to the spinal cord using MRI-guided focused ultrasound

(2015) D Weber-Adrian et al.   GENE THERAPY

Tumor neoantigens: building a framework for personalized cancer immunotherapy

(2015) Matthew M. Gubin et al.   JOURNAL OF CLINICAL INVESTIGATION

70-kDa heat shock protein coated magnetic nanocarriers as a nanovaccine for induction of anti-tumor immune response in experimental glioma

(2015) Maxim A. Shevtsov et al.   JOURNAL OF CONTROLLED RELEASE

18F-Fluoride PET Used for Treatment Monitoring of Systemic Cancer Therapy: Results from the National Oncologic PET Registry

(2015) B. E. Hillner et al.   JOURNAL OF NUCLEAR MEDICINE

Myostatin and IGF-I signaling in end-stage human heart failure: a qRT-PCR study

(2015) Júlia Baán et al.   Journal of Translational Medicine

Mutant MHC class II epitopes drive therapeutic immune responses to cancer

(2015) Sebastian Kreiter et al.   NATURE

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

(2015) Edward B. Garon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pembrolizumab versus Ipilimumab in Advanced Melanoma

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

(2015) B. M. Carreno et al.   SCIENCE

Injectable cryogel-based whole-cell cancer vaccines

(2015) Sidi A. Bencherif et al.   Nature Communications

Injectable, Pore-Forming Hydrogels for In Vivo Enrichment of Immature Dendritic Cells

(2015) Catia S. Verbeke et al.   Advanced Healthcare Materials

Review of the Results of WT1 Peptide Vaccination Strategies for Myelodysplastic Syndromes and Acute Myeloid Leukemia from Nine Different Studies

(2015) Antonio Di Stasi et al.   Frontiers in Immunology

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

(2015) Benjamin Besse et al.   OncoImmunology

Role of Local Radiation Therapy in Cancer Immunotherapy

(2015) Sandra Demaria et al.   JAMA Oncology

Targeted Delivery of Small Interfering RNA Using Reconstituted High-Density Lipoprotein Nanoparticles

(2015) Mian M.K. Shahzad et al.   NEOPLASIA

Ultrasound induced cancer immunotherapy

(2014) Johan Unga et al.   ADVANCED DRUG DELIVERY REVIEWS

Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines

(2014) Raquel P Deering et al.   Expert Opinion on Drug Delivery

Combinations of Radiation Therapy and Immunotherapy for Melanoma: A Review of Clinical Outcomes

(2014) Christopher A. Barker et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

State-of-the-art in design rules for drug delivery platforms: Lessons learned from FDA-approved nanomedicines

(2014) Charlene M. Dawidczyk et al.   JOURNAL OF CONTROLLED RELEASE

TBCRC 008: Early Change in 18F-FDG Uptake on PET Predicts Response to Preoperative Systemic Therapy in Human Epidermal Growth Factor Receptor 2-Negative Primary Operable Breast Cancer

(2014) R. M. Connolly et al.   JOURNAL OF NUCLEAR MEDICINE

Textural Parameters of Tumor Heterogeneity in 18F-FDG PET/CT for Therapy Response Assessment and Prognosis in Patients with Locally Advanced Rectal Cancer

(2014) R. A. Bundschuh et al.   JOURNAL OF NUCLEAR MEDICINE

Multifunctional Tumor pH-Sensitive Self-Assembled Nanoparticles for Bimodal Imaging and Treatment of Resistant Heterogeneous Tumors

(2014) Daishun Ling et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

(2014) Mahesh Yadav et al.   NATURE

Structure-based programming of lymph-node targeting in molecular vaccines

(2014) Haipeng Liu et al.   NATURE

Biopolymer implants enhance the efficacy of adoptive T-cell therapy

(2014) Sirkka B Stephan et al.   NATURE BIOTECHNOLOGY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

A carbon nanotube–polymer composite for T-cell therapy

(2014) Tarek R. Fadel et al.   Nature Nanotechnology

Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model

(2014) Zineb Belcaid et al.   PLoS One

Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors

(2013) J. Duraiswamy et al.   CANCER RESEARCH

Towards a vaccine to prevent cancer in Lynch syndrome patients

(2013) Magnus von Knebel Doeberitz et al.   Familial Cancer

Improving ultrasound gene transfection efficiency by controlling ultrasound excitation of microbubbles

(2013) Z. Fan et al.   JOURNAL OF CONTROLLED RELEASE

In vivo targeting of adoptively transferred T-cells with antibody- and cytokine-conjugated liposomes

(2013) Yiran Zheng et al.   JOURNAL OF CONTROLLED RELEASE

Ultrasound-activated Agents Comprised of 5FU-bearing Nanoparticles Bonded to Microbubbles Inhibit Solid Tumor Growth and Improve Survival

(2013) Caitlin W Burke et al.   MOLECULAR THERAPY

Subnanometer Local Temperature Probing and Remotely Controlled Drug Release Based on Azo-Functionalized Iron Oxide Nanoparticles

(2013) Andreas Riedinger et al.   NANO LETTERS

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion

(2013) Yared Hailemichael et al.   NATURE MEDICINE

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

RNA: The new revolution in nucleic acid vaccines

(2013) Andrew J. Geall et al.   SEMINARS IN IMMUNOLOGY

Superparamagnetic Nanoparticle Clusters for Cancer Theranostics Combining Magnetic Resonance Imaging and Hyperthermia Treatment

(2013) Koichiro Hayashi et al.   Theranostics

Scavenger Receptor B1 is a Potential Biomarker of Human Nasopharyngeal Carcinoma and Its Growth is Inhibited by HDL-mimetic Nanoparticles

(2013) Ying Zheng et al.   Theranostics

The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings, relevant to future cancer therapeutics

(2013) Pedro M. R. Cruz et al.   Frontiers in Pharmacology

Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nanosheets Anchored with Magnetic Nanoparticles

(2012) Kai Yang et al.   ADVANCED MATERIALS

BiVax: a peptide/poly-IC subunit vaccine that mimics an acute infection elicits vast and effective anti-tumor CD8 T-cell responses

(2012) Hyun-Il Cho et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Exploiting the Mutanome for Tumor Vaccination

(2012) J. C. Castle et al.   CANCER RESEARCH

Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens

(2012) Frank Wegmann et al.   NATURE BIOTECHNOLOGY

Microfluidic technologies for accelerating the clinical translation of nanoparticles

(2012) Pedro M. Valencia et al.   Nature Nanotechnology

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Developing mRNA-vaccine technologies

(2012) Thomas Schlake et al.   RNA Biology

A phase I study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen

(2011) Kazuhiro Kakimi et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer Risks Associated With Germline Mutations in MLH1, MSH2, and MSH6 Genes in Lynch Syndrome

(2011) Valérie Bonadona   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Microvesicles and exosomes: Opportunities for cell-derived membrane vesicles in drug delivery

(2011) Susan M. van Dommelen et al.   JOURNAL OF CONTROLLED RELEASE

Immune Response in Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Intranodal Autologous Tumor Lysate-dendritic Cell Vaccination After Radiation Chemotherapy

(2011) Camilo E. Fadul et al.   JOURNAL OF IMMUNOTHERAPY

Exchange-coupled magnetic nanoparticles for efficient heat induction

(2011) Jae-Hyun Lee et al.   Nature Nanotechnology

Imaging of cellular therapies

(2010) M. Srinivas et al.   ADVANCED DRUG DELIVERY REVIEWS

Intranodal Vaccination with Naked Antigen-Encoding RNA Elicits Potent Prophylactic and Therapeutic Antitumoral Immunity

(2010) S. Kreiter et al.   CANCER RESEARCH

Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine

(2010) H S Gill et al.   GENE THERAPY

Evaluation of biodistribution and safety of adenovirus vector containing MDR1 in mice

(2010) ZhenZhen Zhao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Therapeutic cell engineering with surface-conjugated synthetic nanoparticles

(2010) Matthias T Stephan et al.   NATURE MEDICINE

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

MRI-visible polymeric vector bearing CD3 single chain antibody for gene delivery to T cells for immunosuppression

(2009) Guihua Chen et al.   BIOMATERIALS

Clinical and Immunologic Effects of Intranodal Autologous Tumor Lysate-Dendritic Cell Vaccine with Aldesleukin (Interleukin 2) and IFN- 2a Therapy in Metastatic Renal Cell Carcinoma Patients

(2009) T. Schwaab et al.   CLINICAL CANCER RESEARCH

Transcutaneous immunization by lipoplex-patch based DNA vaccines is effective vaccination against Japanese encephalitis virus infection

(2009) Jing-Yan Cheng et al.   JOURNAL OF CONTROLLED RELEASE

In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells

(2009) Ekaterina I. Galanzha et al.   Nature Nanotechnology

A novel strategy utilizing ultrasound for antigen delivery in dendritic cell-based cancer immunotherapy

(2008) Ryo Suzuki et al.   JOURNAL OF CONTROLLED RELEASE

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

(2008) Shengming Dai et al.   MOLECULAR THERAPY

Phase Ib Trial of Mutant Herpes Simplex Virus G207 Inoculated Pre-and Post-tumor Resection for Recurrent GBM

(2008) James M Markert et al.   MOLECULAR THERAPY

DNA vaccines: ready for prime time?

(2008) Michele A. Kutzler et al.   NATURE REVIEWS GENETICS