Serine Protease HtrA2/Omi Deficiency Impairs Mitochondrial Homeostasis and Promotes Hepatic Fibrogenesis via Activation of Hepatic Stellate Cells

Mitochondrial disruption in peroxisome deficient cells is hepatocyte selective but is not mediated by common hepatic peroxisomal metabolites

(2018) Abhijit Babaji Shinde et al.   MITOCHONDRION

The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes

(2018) Ian Gaël Rodrigue-Gervais et al.   Scientific Reports

Alcohol-induced mitochondrial DNA damage promotes injurious crosstalk between alveolar epithelial cells and alveolar macrophages

(2018) Ruxana T. Sadikot et al.   ALCOHOL

Excessive mitochondrial fragmentation triggered by erlotinib promotes pancreatic cancer PANC-1 cell apoptosis via activating the mROS-HtrA2/Omi pathways

(2018) Jun Wan et al.   Cancer Cell International

Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis

(2017) Mireille Khacho et al.   HUMAN MOLECULAR GENETICS

RAR-Related Orphan Receptor Gamma (ROR-γ) Mediates Epithelial-Mesenchymal Transition Of Hepatocytes During Hepatic Fibrosis

(2017) Sung Min Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hepatic stellate cell activation and pro-fibrogenic signals

(2017) Chandrashekhar R. Gandhi   JOURNAL OF HEPATOLOGY

Mitochondrial Function and Cell Size: An Allometric Relationship

(2017) Teemu P. Miettinen et al.   TRENDS IN CELL BIOLOGY

GRIM-19 Restricts HCV Replication by Attenuating Intracellular Lipid Accumulation

(2017) Jung-Hee Kim et al.   Frontiers in Microbiology

Technical Improvement and Application of Hydrodynamic Gene Delivery in Study of Liver Diseases

(2017) Mei Huang et al.   Frontiers in Pharmacology

Hepatic inflammation and fibrosis: Functional links and key pathways

(2015) Ekihiro Seki et al.   HEPATOLOGY

Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction

(2015) Yuliya Mikhed et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

(2015) Santhosh Satapati et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Transcriptional and Metabolic Programs Related to Mammalian Cell Size

(2014) Teemu P. Miettinen et al.   CURRENT BIOLOGY

Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome

(2014) Mitchell R. McGill et al.   HEPATOLOGY

HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA

(2013) Hui-Gwan Goo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease

(2013) Karima Begriche et al.   HEPATOLOGY

A novel role for the mitochondrial HTRA2/OMI protease in aging

(2012) Seokwon Kang et al.   Autophagy

Mitochondrial uncouplers inhibit hepatic stellate cell activation

(2012) Eduardo L Guimarães et al.   BMC GASTROENTEROLOGY

Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging

(2012) S Kang et al.   CELL DEATH AND DIFFERENTIATION

Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure

(2012) Pedro E. Marques et al.   HEPATOLOGY

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating cell-free mitochondrial DNA as a novel cancer biomarker: opportunities and challenges

(2012) Man Yu   Mitochondrial DNA

Targeted therapy of liver fibrosis/cirrhosis and its complications

(2011) Klaas Poelstra et al.   JOURNAL OF HEPATOLOGY

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Evolving challenges in hepatic fibrosis

(2010) Scott L. Friedman   Nature Reviews Gastroenterology & Hepatology

Protection against Hepatocyte Mitochondrial Dysfunction Delays Fibrosis Progression in Mice

(2009) Claudia Mitchell et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

(2009) O. Moiseeva et al.   MOLECULAR AND CELLULAR BIOLOGY

The mitochondrial serine protease HtrA2/Omi: an overview

(2008) L Vande Walle et al.   CELL DEATH AND DIFFERENTIATION

Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells

(2008) Samuele De Minicis et al.   HEPATOLOGY

Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease

(2008) S. Krick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA