Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis

The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C

(2019) Brandon M. D'Arcy et al.   MOLECULAR CANCER THERAPEUTICS

The RIF1-PP1 Axis Controls Abscission Timing in Human Cells

(2019) Rahul Bhowmick et al.   CURRENT BIOLOGY

Hyperphosphorylation of CDH1 in glioblastoma cancer stem cells attenuates APC/CCDH1 activity and pharmacological inhibition of APC/CCDH1/CDC20 compromises viability

(2019) Kuntal De et al.   MOLECULAR CANCER RESEARCH

Role of Polo-like kinase 1 in the regulation of the action of p31comet in the disassembly of mitotic checkpoint complexes

(2019) Sharon Kaisari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Division of labour between PP2A-B56 isoforms at the centromere and kinetochore

(2019) Giulia Vallardi et al.   eLife

Protein phosphatases in chromatin structure and function

(2018) Raquel Sales Gil et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cyclin A-cdk1-Dependent Phosphorylation of Bora Is the Triggering Factor Promoting Mitotic Entry

(2018) Suzanne Vigneron et al.   DEVELOPMENTAL CELL

Phosphoproteome dynamics during mitotic exit in budding yeast

(2018) Sandra A Touati et al.   EMBO JOURNAL

Global assessment of its network dynamics reveals that the kinase Plk1 inhibits the phosphatase PP6 to promote Aurora A activity

(2018) Arminja N. Kettenbach et al.   Science Signaling

Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins

(2018) Isha Nasa et al.   Science Signaling

PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells

(2018) Otto Kauko et al.   Science Translational Medicine

The Importance of Kinase–Phosphatase Integration: Lessons from Mitosis

(2018) Lendert Gelens et al.   TRENDS IN CELL BIOLOGY

Global assessment of its network dynamics reveals that the kinase Plk1 inhibits the phosphatase PP6 to promote Aurora A activity

(2018) Arminja N. Kettenbach et al.   Science Signaling

Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins

(2018) Isha Nasa et al.   Science Signaling

Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B

(2018) Agnieszka Krzyzosiak et al.   CELL

Protein phosphatase 2A as therapeutic targets in various disease models

(2018) Rathinasamy Baskaran et al.   LIFE SCIENCES

Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13

(2018) Claudio Alfieri et al.   NATURE

Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells

(2018) Scott Rata et al.   CURRENT BIOLOGY

Protein phosphatases in the regulation of mitosis

(2018) Jakob Nilsson   JOURNAL OF CELL BIOLOGY

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation

(2018) Matthias Weith et al.   MOLECULAR CELL

A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase

(2018) Meghna Kataria et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates

(2017) Taekyung Kim et al.   GENES & DEVELOPMENT

The Evolution and Functional Diversification of the Deubiquitinating Enzyme Superfamily

(2017) Caitlyn Vlasschaert et al.   Genome Biology and Evolution

New Functions of APC/C Ubiquitin Ligase in the Nervous System and Its Role in Alzheimer’s Disease

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The PP2AB56phosphatase promotes the association of Cdc20 with APC/C in mitosis

(2017) Sun Joo Lee et al.   JOURNAL OF CELL SCIENCE

FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model

(2017) Agata Szymiczek et al.   Journal of Translational Medicine

PP2A Cdc55 Phosphatase Imposes Ordered Cell-Cycle Phosphorylation by Opposing Threonine Phosphorylation

(2017) Molly Godfrey et al.   MOLECULAR CELL

An Attachment-Independent Biochemical Timer of the Spindle Assembly Checkpoint

(2017) Junbin Qian et al.   MOLECULAR CELL

Basis of catalytic assembly of the mitotic checkpoint complex

(2017) Alex C. Faesen et al.   NATURE

Distinct kinetics of serine and threonine dephosphorylation are essential for mitosis

(2017) Jamin B. Hein et al.   NATURE CELL BIOLOGY

Genomics and evolution of protein phosphatases

(2017) Mark J. Chen et al.   Science Signaling

The Ndc80 complex targets Bod1 to human mitotic kinetochores

(2017) Katharina Schleicher et al.   Open Biology

Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C)

(2017) Claudio Alfieri et al.   Open Biology

Genomics and evolution of protein phosphatases

(2017) Mark J. Chen et al.   Science Signaling

Promoter Methylation Analysis of SIRT3, SMARCA5, HTERT and CDH1 Genes in Aging and Alzheimer's Disease

(2017) Patrícia Natália Oliveira Silva et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanisms regulating phosphatase specificity and the removal of individual phosphorylation sites during mitotic exit

(2016) Samuel Rogers et al.   BIOESSAYS

Condensin-Based Chromosome Organization from Bacteria to Vertebrates

(2016) Tatsuya Hirano   CELL

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C

(2016) Nicholas G. Brown et al.   CELL

Safety, Tolerability, and Preliminary Activity of LB-100, an Inhibitor of Protein Phosphatase 2A, in Patients with Relapsed Solid Tumors: An Open-Label, Dose Escalation, First-in-Human, Phase I Trial

(2016) Vincent Chung et al.   CLINICAL CANCER RESEARCH

Two Bistable Switches Govern M Phase Entry

(2016) Satoru Mochida et al.   CURRENT BIOLOGY

A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit

(2016) Michael J. Cundell et al.   JOURNAL OF CELL BIOLOGY

PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells

(2016) Samuel Rogers et al.   JOURNAL OF CELL SCIENCE

Greatwall dephosphorylation and inactivation upon mitotic exit is triggered by PP1

(2016) Sheng Ma et al.   JOURNAL OF CELL SCIENCE

Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex

(2016) Norman E. Davey et al.   MOLECULAR CELL

A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase

(2016) Emil Peter Thrane Hertz et al.   MOLECULAR CELL

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation

(2016) Masaya Yamaguchi et al.   MOLECULAR CELL

Molecular mechanism of APC/C activation by mitotic phosphorylation

(2016) Suyang Zhang et al.   NATURE

Molecular basis of APC/C regulation by the spindle assembly checkpoint

(2016) Claudio Alfieri et al.   NATURE

SMC complexes: from DNA to chromosomes

(2016) Frank Uhlmann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation

(2016) Allison Craney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of APC/CCDC20activation by mitotic phosphorylation

(2016) Renping Qiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclin-dependent kinase 1-dependent activation of APC/C ubiquitin ligase

(2016) K. Fujimitsu et al.   SCIENCE

Expanding the PP2A Interactome by Defining a B56-Specific SLiM

(2016) Xinru Wang et al.   STRUCTURE

Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization

(2016) Jiao Wang et al.   Protein & Cell

The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores

(2016) Sushama Sivakumar et al.   eLife

The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism

(2016) Ganesan Senthil Kumar et al.   eLife

Quantitative framework for ordered degradation of APC/C substrates

(2015) Dan Lu et al.   BMC BIOLOGY

Phosphorylation ofXenopusp31cometpotentiates mitotic checkpoint exit

(2015) Min Mo et al.   CELL CYCLE

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

The ABBA Motif Binds APC/C Activators and Is Shared by APC/C Substrates and Regulators

(2015) Barbara Di Fiore et al.   DEVELOPMENTAL CELL

Protein phosphatase 1 is essential for Greatwall inactivation at mitotic exit

(2015) A. Heim et al.   EMBO REPORTS

All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase

(2015) Jaya Sangodkar et al.   FEBS Journal

The selective inhibition of protein phosphatase-1 results in mitotic catastrophe and impaired tumor growth

(2015) C. Winkler et al.   JOURNAL OF CELL SCIENCE

Metals in the active site of native protein phosphatase-1

(2015) Ewald Heroes et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs

(2015) Rachael A. McCloy et al.   MOLECULAR & CELLULAR PROTEOMICS

Atomic structure of the APC/C and its mechanism of protein ubiquitination

(2015) Leifu Chang et al.   NATURE

Reconstitution of mitotic chromatids with a minimum set of purified factors

(2015) Keishi Shintomi et al.   NATURE CELL BIOLOGY

Spatiotemporal regulation of the anaphase-promoting complex in mitosis

(2015) Sushama Sivakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling

(2015) Y. Hiruma et al.   SCIENCE

Centromeric binding and activity of Protein Phosphatase 4

(2015) Zoltan Lipinszki et al.   Nature Communications

Cdk1 orders mitotic events through coordination of a chromosome-associated phosphatase switch

(2015) Junbin Qian et al.   Nature Communications

Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer

(2015) Hao Liu et al.   Oncotarget

Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells

(2015) Susanne Lub et al.   Oncotarget

Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells

(2015) Conrad von Schubert et al.   Cell Reports

Activation of the APC/C Ubiquitin Ligase by Enhanced E2 Efficiency

(2014) Vanessa A. Van Voorhis et al.   CURRENT BIOLOGY

PP2A delays APC/C-dependent degradation of separase-associated but not free securin

(2014) S. Hellmuth et al.   EMBO JOURNAL

APC/Cdh E3 ubiquitin ligase in the pathophysiology of Alzheimer׳s disease

(2014) Jose Vina et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phosphorylation Regulates the p31Comet-Mitotic Arrest-deficient 2 (Mad2) Interaction to Promote Spindle Assembly Checkpoint (SAC) Activity

(2014) Dipali A. Date et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cdc20-binding Phe Box of the Spindle Checkpoint Protein BubR1 Maintains the Mitotic Checkpoint Complex During Mitosis

(2014) Laura A. Diaz-Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing

(2014) Antonio Espert et al.   JOURNAL OF CELL BIOLOGY

KIF4A and PP2A–B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle

(2014) Ricardo Nunes Bastos et al.   JOURNAL OF CELL BIOLOGY

Multiple mechanisms determine the order of APC/C substrate degradation in mitosis

(2014) Dan Lu et al.   JOURNAL OF CELL BIOLOGY

Usingin VivoBiotinylated Ubiquitin to Describe a Mitotic Exit Ubiquitome from Human Cells

(2014) Mingwei Min et al.   MOLECULAR & CELLULAR PROTEOMICS

The spindle and kinetochore–associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit

(2014) Sushama Sivakumar et al.   MOLECULAR BIOLOGY OF THE CELL

The Cdk/Cdc14 Module Controls Activation of the Yen1 Holliday Junction Resolvase to Promote Genome Stability

(2014) Christie L. Eissler et al.   MOLECULAR CELL

Microtubule-Dependent Regulation of Mitotic Protein Degradation

(2014) Ling Song et al.   MOLECULAR CELL

Dephosphorylation Enables the Recruitment of 53BP1 to Double-Strand DNA Breaks

(2014) Dong-Hyun Lee et al.   MOLECULAR CELL

The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C

(2014) Daisuke Izawa et al.   NATURE

Molecular architecture and mechanism of the anaphase-promoting complex

(2014) Leifu Chang et al.   NATURE

A PP1–PP2A phosphatase relay controls mitotic progression

(2014) Agnes Grallert et al.   NATURE

Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C

(2014) Katharine L. Sackton et al.   NATURE

Negative feedback at kinetochores underlies a responsive spindle checkpoint signal

(2014) Wilco Nijenhuis et al.   NATURE CELL BIOLOGY

Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling

(2014) Kirti Sharma et al.   Cell Reports

Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers

(2014) Byron C Williams et al.   eLife

Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with γ-tubulin

(2013) Martin Voss et al.   CELL CYCLE

Inhibition of Protein Phosphatase 2A Radiosensitizes Pancreatic Cancers by Modulating CDC25C/CDK1 and Homologous Recombination Repair

(2013) D. Wei et al.   CLINICAL CANCER RESEARCH

Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C–Cdc20 complex

(2013) Garry G Sedgwick et al.   EMBO JOURNAL

Regulation of α-endosulfine, an inhibitor of protein phosphatase 2A, by multisite phosphorylation

(2013) Satoru Mochida   FEBS Journal

Panta rhei: The APC/C at steady state

(2013) Ivana Primorac et al.   JOURNAL OF CELL BIOLOGY

Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression

(2013) T. Kruse et al.   JOURNAL OF CELL SCIENCE

CDC20 overexpression predicts a poor prognosis for patients with colorectal cancer

(2013) Wen-jing Wu et al.   Journal of Translational Medicine

Global Analysis of Cdc14 Dephosphorylation Sites Reveals Essential Regulatory Role in Mitosis and Cytokinesis

(2013) Li Kao et al.   MOLECULAR & CELLULAR PROTEOMICS

B56  Tumor-Associated Mutations Provide New Mechanisms for B56 -PP2A Tumor Suppressor Activity

(2013) Y. Nobumori et al.   MOLECULAR CANCER RESEARCH

The BEG (PP2A-B55/ENSA/Greatwall) Pathway Ensures Cytokinesis follows Chromosome Separation

(2013) Michael J. Cundell et al.   MOLECULAR CELL

Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex

(2013) Jun He et al.   MOLECULAR CELL

Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation

(2013) Lilian Kabeche et al.   NATURE

Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown

(2013) Jeremiah J Frye et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cks confers specificity to phosphorylation-dependent CDK signaling pathways

(2013) Denise A McGrath et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multisite phosphorylation networks as signal processors for Cdk1

(2013) Mardo Kõivomägi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin

(2013) T. Nishiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bod1 regulates protein phosphatase 2A at mitotic kinetochores

(2013) Iain M. Porter et al.   Nature Communications

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Spatial Positive Feedback at the Onset of Mitosis

(2012) Silvia D.M. Santos et al.   CELL

CDK-Dependent Potentiation of MPS1 Kinase Activity Is Essential to the Mitotic Checkpoint

(2012) Violeta Morin et al.   CURRENT BIOLOGY

Separase Sensor Reveals Dual Roles for Separase Coordinating Cohesin Cleavage and Cdk1 Inhibition

(2012) Norihisa Shindo et al.   DEVELOPMENTAL CELL

The Kinetochore-Bound Ska1 Complex Tracks Depolymerizing Microtubules and Binds to Curved Protofilaments

(2012) Jens C. Schmidt et al.   DEVELOPMENTAL CELL

Dephosphorylation of Cdc20 is required for its C-box-dependent activation of the APC/C

(2012) Helene Labit et al.   EMBO JOURNAL

Structural basis for protein phosphatase 1 regulation and specificity

(2012) Wolfgang Peti et al.   FEBS Journal

The PP1 binding code: a molecular-lego strategy that governs specificity

(2012) Ewald Heroes et al.   FEBS Journal

Aurora B controls kinetochore–microtubule attachments by inhibiting Ska complex–KMN network interaction

(2012) Ying Wai Chan et al.   JOURNAL OF CELL BIOLOGY

Overexpression of CDC20 predicts poor prognosis in primary non-small cell lung cancer patients

(2012) Tatsuya Kato et al.   JOURNAL OF SURGICAL ONCOLOGY

Determinants for Activation of the Atypical AGC Kinase Greatwall during M Phase Entry

(2012) K. A. Blake-Hodek et al.   MOLECULAR AND CELLULAR BIOLOGY

Structure of the mitotic checkpoint complex

(2012) William C. H. Chao et al.   NATURE

Phosphorylation-enabled binding of SGO1–PP2A to cohesin protects sororin and centromeric cohesion during mitosis

(2012) Hong Liu et al.   NATURE CELL BIOLOGY

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

(2012) Emily A. Foley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural analysis of human Cdc20 supports multisite degron recognition by APC/C

(2012) W. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Quantitative Model for Ordered Cdk Substrate Dephosphorylation during Mitotic Exit

(2011) Céline Bouchoux et al.   CELL

The Spatial Arrangement of Chromosomes during Prometaphase Facilitates Spindle Assembly

(2011) Valentin Magidson et al.   CELL

PP1/Repo-Man Dephosphorylates Mitotic Histone H3 at T3 and Regulates Chromosomal Aurora B Targeting

(2011) Junbin Qian et al.   CURRENT BIOLOGY

Repo-Man Coordinates Chromosomal Reorganization with Nuclear Envelope Reassembly during Mitotic Exit

(2011) Paola Vagnarelli et al.   DEVELOPMENTAL CELL

The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II

(2011) S. Abe et al.   GENES & DEVELOPMENT

Cdc14 Phosphatases Preferentially Dephosphorylate a Subset of Cyclin-dependent kinase (Cdk) Sites Containing Phosphoserine

(2011) Steven C. Bremmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the Mechanisms Controlling Greatwall Activity

(2011) S. Vigneron et al.   MOLECULAR AND CELLULAR BIOLOGY

Human Cancer-Associated Mutations in the A  Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in A  Knock-In and Knockout Mice

(2011) R. Ruediger et al.   MOLECULAR AND CELLULAR BIOLOGY

Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast

(2011) Yuu Kimata et al.   MOLECULAR BIOLOGY OF THE CELL

Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited

(2011) Tamara A. Potapova et al.   MOLECULAR BIOLOGY OF THE CELL

Modulation of Protein Phosphatase 2A Activity Alters Androgen-Independent Growth of Prostate Cancer Cells: Therapeutic Implications

(2011) A. Bhardwaj et al.   MOLECULAR CANCER THERAPEUTICS

Structural basis for the subunit assembly of the anaphase-promoting complex

(2011) Anne Schreiber et al.   NATURE

Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase

(2011) Emily A. Foley et al.   NATURE CELL BIOLOGY

Cubism and the cell cycle: the many faces of the APC/C

(2011) Jonathon Pines   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint-Dependent Mitotic Arrest in the Absence of Spindle Damage

(2010) Xing Zeng et al.   CANCER CELL

Targeting Mitotic Exit Leads to Tumor Regression In Vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ Phosphatase

(2010) Eusebio Manchado et al.   CANCER CELL

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E

(2010) Yumi Kim et al.   CELL

Sli15INCENP Dephosphorylation Prevents Mitotic Checkpoint Reengagement Due to Loss of Tension at Anaphase Onset

(2010) Lesia Mirchenko et al.   CURRENT BIOLOGY

Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis

(2010) Olivier Gavet et al.   DEVELOPMENTAL CELL

How cyclin A destruction escapes the spindle assembly checkpoint

(2010) Barbara Di Fiore et al.   JOURNAL OF CELL BIOLOGY

Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase

(2010) Dan Liu et al.   JOURNAL OF CELL BIOLOGY

Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2

(2010) Kang Zeng et al.   JOURNAL OF CELL BIOLOGY

Driving the cell cycle with a minimal CDK control network

(2010) Damien Coudreuse et al.   NATURE

Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells

(2010) Michael H. A. Schmitz et al.   NATURE CELL BIOLOGY

The Substrate of Greatwall Kinase, Arpp19, Controls Mitosis by Inhibiting Protein Phosphatase 2A

(2010) A. Gharbi-Ayachi et al.   SCIENCE

Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2A That Is Essential for Mitosis

(2010) S. Mochida et al.   SCIENCE

Survivin Reads Phosphorylated Histone H3 Threonine 3 to Activate the Mitotic Kinase Aurora B

(2010) Alexander E. Kelly et al.   SCIENCE

Protein Architecture of the Human Kinetochore Microtubule Attachment Site

(2009) Xiaohu Wan et al.   CELL

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

Protein phosphatases take the mitotic stage

(2009) Peter De Wulf et al.   CURRENT OPINION IN CELL BIOLOGY

BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis

(2009) Eunhee Choi et al.   EMBO JOURNAL

Regulated activity of PP2A–B55δ is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts

(2009) Satoru Mochida et al.   EMBO JOURNAL

Polo Kinase Regulates Mitotic Chromosome Condensation by Hyperactivation of Condensin DNA Supercoiling Activity

(2009) Julie St-Pierre et al.   MOLECULAR CELL

Structure and Function of the PP2A-Shugoshin Interaction

(2009) Zheng Xu et al.   MOLECULAR CELL

Irreversibility of mitotic exit is the consequence of systems-level feedback

(2009) Sandra López-Avilés et al.   NATURE

PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation

(2009) Judy Qiju Wu et al.   NATURE CELL BIOLOGY

Phosphorylation of H2A by Bub1 Prevents Chromosomal Instability Through Localizing Shugoshin

(2009) S. A. Kawashima et al.   SCIENCE

Regulation of Skp2-p27 Axis by the Cdh1/Anaphase-Promoting Complex Pathway in Colorectal Tumorigenesis

(2008) Takeo Fujita et al.   AMERICAN JOURNAL OF PATHOLOGY

The Cdc14B-Cdh1-Plk1 Axis Controls the G2 DNA-Damage-Response Checkpoint

(2008) Florian Bassermann et al.   CELL

Dissection of the APCCdh1-Skp2 Cascade in Breast Cancer

(2008) T. Fujita et al.   CLINICAL CANCER RESEARCH

APC/CCdh1 Targets Aurora Kinase to Control Reorganization of the Mitotic Spindle at Anaphase

(2008) Suzanne Floyd et al.   CURRENT BIOLOGY

Cdk-counteracting phosphatases unlock mitotic exit

(2008) Ethel Queralt et al.   CURRENT OPINION IN CELL BIOLOGY

Cdc20 and Cks Direct the Spindle Checkpoint-Independent Destruction of Cyclin A

(2008) Rob Wolthuis et al.   MOLECULAR CELL

A Role for the Fizzy/Cdc20 Family of Proteins in Activation of the APC/C Distinct from Substrate Recruitment

(2008) Yuu Kimata et al.   MOLECULAR CELL

Positive feedback sharpens the anaphase switch

(2008) Liam J. Holt et al.   NATURE

The TBP–PP2A mitotic complex bookmarks genes by preventing condensin action

(2008) Hongyan Xing et al.   NATURE CELL BIOLOGY

Genomic stability and tumour suppression by the APC/C cofactor Cdh1

(2008) Irene García-Higuera et al.   NATURE CELL BIOLOGY

The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

(2008) Jakob Nilsson et al.   NATURE CELL BIOLOGY

Linear Motif Atlas for Phosphorylation-Dependent Signaling

(2008) M. L. Miller et al.   Science Signaling