The Intrinsically Disordered C-Terminal Domain Triggers Nucleolar Localization and Function Switch of PARN in Response to DNA Damage

Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease

(2019) Caitlin M. Roake et al.   MOLECULAR CELL

The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation

(2019) Siddharth Shukla et al.   MOLECULAR CELL

PNLDC1, mouse pre‐piRNA Trimmer, is required for meiotic and post‐meiotic male germ cell development

(2018) Toru Nishimura et al.   EMBO REPORTS

PARN and TOE1 Constitute a 3′ End Maturation Module for Nuclear Non-coding RNAs

(2018) Ahyeon Son et al.   Cell Reports

Poly(A)-specific ribonuclease sculpts the 3' ends of microRNAs

(2018) Dooyoung Lee et al.   RNA

Elucidating binding mechanisms and dynamics of intrinsically disordered protein complexes using NMR spectroscopy

(2018) Robert Schneider et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

PARN Modulates Y RNA Stability and Its 3′-End Formation

(2017) Siddharth Shukla et al.   MOLECULAR AND CELLULAR BIOLOGY

Short poly(A) tails are a conserved feature of highly expressed genes

(2017) Sarah Azoubel Lima et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Poly(A)-specific ribonuclease is a nuclear ribosome biogenesis factor involved in human 18S rRNA maturation

(2017) Christian Montellese et al.   NUCLEIC ACIDS RESEARCH

PNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice

(2017) Deqiang Ding et al.   Nature Communications

Short poly(A) tails are a conserved feature of highly expressed genes

(2017) Sarah Azoubel Lima et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Poly(A) tail length regulates PABPC1 expression to tune translation in the heart

(2017) Sandip Chorghade et al.   eLife

Identification and Functional Analysis of the Pre-piRNA 3′ Trimmer in Silkworms

(2016) Natsuko Izumi et al.   CELL

Coupled binding and folding of intrinsically disordered proteins: what can we learn from kinetics?

(2016) Stefano Gianni et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Regulation of Poly(A) Tail and Translation during the Somatic Cell Cycle

(2016) Jong-Eun Park et al.   MOLECULAR CELL

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

(2016) Siddharth Shukla et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

(2016) Siddharth Shukla et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Depletion of poly(A)-specific ribonuclease (PARN) inhibits proliferation of human gastric cancer cells by blocking cell cycle progression

(2015) Li-Na Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita

(2015) Hemanth Tummala et al.   JOURNAL OF CLINICAL INVESTIGATION

Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component

(2015) Diane H Moon et al.   NATURE GENETICS

Destabilization of microRNAs in human cells by 3′ deadenylation mediated by PARN and CUGBP1

(2015) Takayuki Katoh et al.   NUCLEIC ACIDS RESEARCH

PARN deadenylase is involved in miRNA-dependent degradation of TP53 mRNA in mammalian cells

(2015) Xiaokan Zhang et al.   NUCLEIC ACIDS RESEARCH

A Polyadenylation-Dependent 3′ End Maturation Pathway Is Required for the Synthesis of the Human Telomerase RNA

(2015) Duy Nguyen et al.   Cell Reports

Human Telomerase RNA Processing and Quality Control

(2015) Chi-Kang Tseng et al.   Cell Reports

Self-association of poly(A)-specific ribonuclease (PARN) triggered by the R3H domain

(2014) Guang-Jun He et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

(2014) Alaji Bah et al.   NATURE

Poly(A)-tail profiling reveals an embryonic switch in translational control

(2014) Alexander O. Subtelny et al.   NATURE

Destabilization of nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fibre formation

(2014) Anne Cammas et al.   Nature Communications

Deadenylation: enzymes, regulation, and functional implications

(2014) Yong-Bin Yan   Wiley Interdisciplinary Reviews-RNA

Distinct roles of the R3H and RRM domains in poly(A)-specific ribonuclease structural integrity and catalysis

(2013) Guang-Jun He et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Poly(A)-specific ribonuclease (PARN): An allosterically regulated, processive and mRNA cap-interacting deadenylase

(2013) Anders Virtanen et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Positive and negative feedback loops in the p53 and mRNA 3′ processing pathways

(2013) Emral Devany et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(A)-Specific Ribonuclease Mediates 3′-End Trimming of Argonaute2-Cleaved Precursor MicroRNAs

(2013) Mayuko Yoda et al.   Cell Reports

Alterations of Deadenylase Expression in Acute Leukemias: Evidence for Poly(A)-Specific Ribonuclease as a Potential Biomarker

(2012) Panayiotis Maragozidis et al.   ACTA HAEMATOLOGICA

Modulation of Poly(A)-specific Ribonuclease (PARN): Current Knowledge and Perspectives

(2012) N. A.A. Balatsos et al.   CURRENT MEDICINAL CHEMISTRY

A Deadenylase Assay by Size-Exclusion Chromatography

(2012) Guang-Jun He et al.   PLoS One

Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming

(2012) H. Berndt et al.   RNA

Global architecture of human poly(A)-specific ribonuclease by atomic force microscopy in liquid and dynamic light scattering

(2011) Anna Niedzwiecka et al.   BIOPHYSICAL CHEMISTRY

NoD: a Nucleolar localization sequence detector for eukaryotic and viral proteins

(2011) Michelle S Scott et al.   BMC BIOINFORMATICS

To polyadenylate or to deadenylate

(2010) Xiaokan Zhang et al.   CELL CYCLE

Nuclear deadenylation/polyadenylation factors regulate 3′ processing in response to DNA damage

(2010) Murat A Cevher et al.   EMBO JOURNAL

DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization

(2010) H. Christian Reinhardt et al.   MOLECULAR CELL

The protein kingdom extended: Ordered and intrinsically disordered proteins, their folding, supramolecular complex formation, and aggregation

(2010) Konstantin K. Turoverov et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Conformational stability and multistate unfolding of poly(A)-specific ribonuclease

(2009) Guang-Jun He et al.   FEBS Journal

Recognition of Adenosine Residues by the Active Site of Poly(A)-specific Ribonuclease

(2009) Niklas Henriksson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the Antiproliferative Activity of the Tob-hCaf1 Complex

(2009) Masataka Horiuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of m7GpppG Binding to Poly(A)-Specific Ribonuclease

(2009) Mousheng Wu et al.   STRUCTURE

Allosteric regulation of human poly(A)-specific ribonuclease by cap and potassium ions

(2008) Wei-Feng Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crystal Structure of the RRM Domain of Poly(A)-Specific Ribonuclease Reveals a Novel m7G-Cap-Binding Mode

(2008) Thomas Monecke et al.   JOURNAL OF MOLECULAR BIOLOGY

Multifunctional deadenylase complexes diversify mRNA control

(2008) Aaron C. Goldstrohm et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY