Review
Cell Biology
Tzitzijanik Madrigal, Jesus Hernandez-Monge, Luis A. Herrera, Claudia Haydee Gonzalez-De la Rosa, Guadalupe Dominguez-Gomez, Myrna Candelaria, Fernando Luna-Maldonado, Karla G. Calderon Gonzalez, Jose Diaz-Chavez
Summary: Mutations in the DNA-binding domain of p53 can give rise to different variants with new functions, known as Gain-of-function p53 mutants. Recent studies have shown that p53 mutants regulate gene expression by unbalancing specific microRNAs levels, affecting cellular processes such as epithelial-mesenchymal transition, chemoresistance, and cell survival.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Olga Patutina, Daria Chiglintseva, Bahareh Amirloo, David Clarke, Svetlana Gaponova, Valentin Vlassov, Elena Bichenkova, Marina Zenkova
Summary: In this study, BC-miRNases were successfully engineered to recognize and destroy oncogenic miR-17 and miR-21. The sequence of miRNA bulge loops and neighbouring motifs were found to be crucial for efficient miRNA cleavage. The incorporation of a second catalytic peptide increased the potency of BC-miRNase, and the cooperation with RNase H accelerated the rate of miRNA catalytic cleavage, achieving the desired therapeutic effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Rackhyun Park, Minsu Jang, Yea-In Park, Yeonjeong Park, Sim Namkoong, Jin Lee, Junsoo Park
Summary: This study demonstrates that elevated levels of CTRP1 in obesity significantly contribute to tumor progression, potentially by regulating the tumor suppressor p53. The molecular mechanisms linking obesity with cancer remain largely uninvestigated.
Review
Biotechnology & Applied Microbiology
Fang Liu, Rongfeng Qu, Limin Yang, Guang Shi, Shuhong Hao, Chunmei Hu
Summary: Circular RNAs (circRNAs) participate in the occurrence and development of various diseases through different mechanisms, including acting as a miRNA sponge, interacting with RNA-binding proteins, and regulating gene transcription and protein translation. Specifically in tumors, abnormal expression of circRNAs can disrupt the cell cycle network and promote tumor development and metastasis. Extensive studies have been conducted on the abnormal expression of circRNAs in different cancer types, and their ability to regulate the cell cycle through diverse mechanisms holds great significance for tumor diagnosis, treatment, and prognosis. This review provides insights into the circRNA-mediated regulation of the cell cycle in tumors and its potential applications in cancer research and therapy.
ONCOTARGETS AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ullas Valiya Chembazhi, Wesley S. Tung, Hyojeong Hwang, Yuexi Wang, Aryan Lalwani, Ka Lam Nguyen, Sushant Bangru, Danielle Yee, Kristy Chin, Jing Yang, Auinash Kalsotra, Wenyan Mei
Summary: Intestinal epithelial regeneration is driven by intestinal stem cells. Upon the loss of intestinal stem cells, differentiated intestinal epithelial cells, such as Paneth cells, are capable of acquiring multipotency and contributing to regeneration. Depletion of an RNA-binding protein named PTBP1 in mouse intestinal epithelial cells leads to intestinal stem cell death and epithelial regeneration failure.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Endocrinology & Metabolism
Cecilia Catellani, Gloria Ravegnini, Chiara Sartori, Beatrice Righi, Pietro Lazzeroni, Laura Bonvicini, Silvia Poluzzi, Francesca Cirillo, Barbara Predieri, Lorenzo Iughetti, Paolo Giorgi Rossi, Sabrina Angelini, Maria Elisabeth Street
Summary: This study found that the expression of miR-199a-5p, miR-335-5p, and miR-494-3p changed after 3 months of GH treatment in patients with IIGHD, which might reflect the degree of GH deficiency and the sensitivity to treatment. Furthermore, these miRNA changes were of considerable importance in predicting growth response.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Li-Ting Diao, Shu-Juan Xie, Hang Lei, Xiu-Sheng Qiu, Meng-Chun Huang, Shuang Tao, Ya-Rui Hou, Yan-Xia Hu, Yu-Jia Sun, Qi Zhang, Zhen-Dong Xiao
Summary: METTL3 increases mature miRNA levels by modifying pri-miRNA transcripts through m6A, but surprisingly represses muscle-specific miRNAs in C2C12 cells and mouse skeletal muscle regeneration models. This repression may involve both transcriptional and post-transcriptional regulations.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Dimitris C. Kanellis, Jaime A. Espinoza, Asimina Zisi, Elpidoforos Sakkas, Jirina Bartkova, Anna-Maria Katsori, Johan Bostrom, Lars Dyrskjot, Helle Broholm, Mikael Altun, Simon J. Elsasser, Mikael S. Lindstrom, Jiri Bartek
Summary: eIF4A3 plays a role in ribosome biogenesis and p53 regulation, with its depletion leading to cell cycle arrest and changes in cell death regulation pathways. The expression and subnuclear localization of eIF4A3 among clinical cancer specimens correlate with RiBi status, impacting cancer pathogenesis and treatment.
Article
Oncology
Julia Paczkowska, Joanna Janiszewska, Adam Ustaszewski, Julia Bein, Marcin Skalski, Agnieszka Dzikiewicz-Krawczyk, Natalia Rozwadowska, Martin-Leo Hansmann, Sylvia Hartmann, Maciej Giefing
Summary: Studies have shown that miRNAs play an important role in classical Hodgkin lymphoma (cHL), leading to the loss of B-cell phenotype and NF-kappa B activation. Furthermore, miRNAs regulate this process by targeting B-cell-related transcription factors and NF-kappa B inhibitors.
Article
Biochemistry & Molecular Biology
Takahiro Umehara, Ryoichi Mori, Kimberly A. Mace, Katsumi Tanaka, Noriho Sakamoto, Kazuya Ikematsu, Hiroaki Sato
Summary: The dysfunction of microRNAs in diabetic-derived neutrophils and the potential role of circular RNAs in regulating inflammation have been investigated.
Article
Geosciences, Multidisciplinary
Claire E. Rapp, Robyn S. Wilson
Summary: Wildland fire incident management teams require sustained and coordinated decision making. Trust is crucial for efficient information flow and adaptation, but existing trust models mainly focus on routine business teams. Results indicate that ability, integrity, benevolence, predictability, and gender contribute to trustworthiness.
INTERNATIONAL JOURNAL OF DISASTER RISK REDUCTION
(2022)
Article
Plant Sciences
Sang-Jin Kim, Starla Zemelis-Durfee, Brian Mckinley, Rylee Sokoloski, William Aufdemberge, John Mullet, Federica Brandizzi
Summary: Mixed-linkage glucan (MLG) is a component of the cell wall of grasses and plays important roles in carbohydrate storage and structural support. MLG levels are regulated by cellulose synthase-like (CSL) enzymes and lichenases. In this study, three functional sorghum lichenases were identified and characterized, showing that they are involved in MLG degradation in the extracellular space. The expression of the lichenase genes exhibited specific patterns related to development, cell type, and diurnal regulation. These findings have implications for improving sorghum as a feedstock.
Article
Pharmacology & Pharmacy
Sebastian Guelman, Ying Zhou, Ann Brady, Kun Peng
Summary: Autogene cevumeran is a personalized therapy for solid tumors that stimulates and expands neoantigen-specific T cells. In order to evaluate the therapy's performance in patients, lipid and mRNA content in circulation need to be measured, and a method to measure mRNA levels in plasma needs to be established. Special precautions are required to preserve mRNA integrity during sample collection and storage.
Article
Biochemistry & Molecular Biology
Mathieu Lussier-Price, Haytham M. Wahba, Xavier H. Mascle, Laurent Cappadocia, Veronique Bourdeau, Christina Gagnon, Sebastian Igelmann, Kazuyasu Sakaguchi, Gerardo Ferbeyre, James G. Omichinski
Summary: The N-terminal region of SUMO proteins plays an auto-inhibition role in promoting PML-NB formation, and this auto-inhibition can be relieved by zinc, leading to increased PML-NB formation within cells.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
H. Helena Wu, Benfan Wang, Stephen R. Armstrong, Yasser Abuetabh, Sarah Leng, Wilson H. Y. Roa, Azeddine Atfi, Adriano Marchese, Beverly Wilson, Consolato Sergi, Elsa R. Flores, David D. Eisenstat, Roger P. Leng
Summary: The study revealed that Hsp70 regulates the ubiquitination and degradation of p63 isoforms mediated by CHIP, playing a crucial role in the migration and invasion of tumor cells.
NUCLEIC ACIDS RESEARCH
(2021)
