Deadenylation: enzymes, regulation, and functional implications

Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs

(2013) Kathrin Leppek et al.   CELL

Poly(A)-specific ribonuclease (PARN): An allosterically regulated, processive and mRNA cap-interacting deadenylase

(2013) Anders Virtanen et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Exonuclease hDIS3L2 specifies an exosome-independent 3′-5′ degradation pathway of human cytoplasmic mRNA

(2013) Michal Lubas et al.   EMBO JOURNAL

The exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway

(2013) Michal Malecki et al.   EMBO JOURNAL

GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation

(2013) Latifa Zekri et al.   EMBO JOURNAL

Pbp1 Is Involved in Ccr4- and Khd1-Mediated Regulation of Cell Growth through Association with Ribosomal Proteins Rpl12a and Rpl12b

(2013) Yuichi Kimura et al.   EUKARYOTIC CELL

The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2

(2013) B. Loh et al.   GENES & DEVELOPMENT

Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1)

(2013) Monika Hämmerle et al.   HEPATOLOGY

Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1

(2013) W. Zhou et al.   JOURNAL OF CELL SCIENCE

A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28–let-7 pathway

(2013) Hao-Ming Chang et al.   NATURE

Cytoplasmic RNA: a case of the tail wagging the dog

(2013) Chris J. Norbury   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure and assembly of the NOT module of the human CCR4–NOT complex

(2013) Andreas Boland et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and RNA-binding properties of the Not1–Not2–Not5 module of the yeast Ccr4–Not complex

(2013) Varun Bhaskar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by tristetraprolin

(2013) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Biochemical and Biophysical Characterization of the Deadenylase CrCaf1 from Chlamydomonas reinhardtii

(2013) Jia-Quan Zhang et al.   PLoS One

C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex

(2013) Fabienne Mauxion et al.   RNA Biology

NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain

(2013) Praveen Bawankar et al.   RNA Biology

Phosphorylation at intrinsically disordered regions of PAM2 motif-containing proteins modulates their interactions with PABPC1 and influences mRNA fate

(2013) K.-L. Huang et al.   RNA

Alterations of Deadenylase Expression in Acute Leukemias: Evidence for Poly(A)-Specific Ribonuclease as a Potential Biomarker

(2012) Panayiotis Maragozidis et al.   ACTA HAEMATOLOGICA

Modulation of Poly(A)-specific Ribonuclease (PARN): Current Knowledge and Perspectives

(2012) N. A.A. Balatsos et al.   CURRENT MEDICINAL CHEMISTRY

Human Pumilio Proteins Recruit Multiple Deadenylases to Efficiently Repress Messenger RNAs

(2012) Jamie Van Etten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architecture of the Nuclease Module of the Yeast Ccr4-Not Complex: the Not1-Caf1-Ccr4 Interaction

(2012) Jérôme Basquin et al.   MOLECULAR CELL

Translational control by changes in poly(A) tail length: recycling mRNAs

(2012) Laure Weill et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4–NOT deadenylase complex

(2012) Alain-Pierre Petit et al.   NUCLEIC ACIDS RESEARCH

The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets

(2012) Eric Huntzinger et al.   NUCLEIC ACIDS RESEARCH

Antiproliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic polyadenylation element-binding protein CPEB

(2012) K Ogami et al.   ONCOGENE

A Deadenylase Assay by Size-Exclusion Chromatography

(2012) Guang-Jun He et al.   PLoS One

Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming

(2012) H. Berndt et al.   RNA

Nocturnin: at the crossroads of clocks and metabolism

(2012) Jeremy J. Stubblefield et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The PARN Deadenylase Targets a Discrete Set of mRNAs for Decay and Regulates Cell Motility in Mouse Myoblasts

(2012) Jerome E. Lee et al.   PLoS Genetics

Poly(A) binding proteins: are they all created equal?

(2012) Dixie J. Goss et al.   Wiley Interdisciplinary Reviews-RNA

Distinct expression patterns of the subunits of the CCR4–NOT deadenylase complex during neural development

(2011) Chuan Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Global architecture of human poly(A)-specific ribonuclease by atomic force microscopy in liquid and dynamic light scattering

(2011) Anna Niedzwiecka et al.   BIOPHYSICAL CHEMISTRY

Promoter Elements Regulate Cytoplasmic mRNA Decay

(2011) Almog Bregman et al.   CELL

Single-Molecule mRNA Decay Measurements Reveal Promoter- Regulated mRNA Stability in Yeast

(2011) Tatjana Trcek et al.   CELL

Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response?

(2011) H. Christian Reinhardt et al.   CELL CYCLE

Coordinate regulation of mRNA decay networks by GU-rich elements and CELF1

(2011) Irina Vlasova-St. Louis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase

(2011) Nao Hosoda et al.   EMBO JOURNAL

Nucleophosmin deposition during mRNA 3′ end processing influences poly(A) tail length

(2011) Fumihiko Sagawa et al.   EMBO JOURNAL

Insights into the structure of the CCR4-NOT complex by electron microscopy

(2011) Fariborz Nasertorabi et al.   FEBS LETTERS

The Ccr4–Not complex

(2011) Martine A. Collart et al.   GENE

Dissimilar Roles of the Four Conserved Acidic Residues in the Thermal Stability of Poly(A)-Specific Ribonuclease

(2011) Guang-Jun He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells

(2011) Christoph Weber et al.   Journal of Proteomics

The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4–Not complex contribute to the prevention of cell death and senescence

(2011) Saloni Mittal et al.   MOLECULAR BIOLOGY OF THE CELL

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

(2011) Joerg E. Braun et al.   MOLECULAR CELL

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT

(2011) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing motifs

(2011) Marina Chekulaeva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Saccharomyces cerevisiae Ngl3p is an active 3′–5′ exonuclease with a specificity towards poly-A RNA reminiscent of cellular deadenylases

(2011) Ane Feddersen et al.   NUCLEIC ACIDS RESEARCH

Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin

(2011) Heike Sandler et al.   NUCLEIC ACIDS RESEARCH

PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria

(2011) Joanna Rorbach et al.   NUCLEIC ACIDS RESEARCH

Human 2′-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover

(2011) Jesper Buchhave Poulsen et al.   NUCLEIC ACIDS RESEARCH

Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation

(2011) Y. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modifications of Small RNAs and Their Associated Proteins

(2010) Young-Kook Kim et al.   CELL

To polyadenylate or to deadenylate

(2010) Xiaokan Zhang et al.   CELL CYCLE

Nuclear deadenylation/polyadenylation factors regulate 3′ processing in response to DNA damage

(2010) Murat A Cevher et al.   EMBO JOURNAL

Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity

(2010) Hui Wang et al.   EMBO JOURNAL

MAPKAP Kinase 2 Blocks Tristetraprolin-directed mRNA Decay by Inhibiting CAF1 Deadenylase Recruitment

(2010) Francesco P. Marchese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Characterization of Pumilio1 and Pumilio2 inXenopusOocytes

(2010) Ryoma Ota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Tristetraprolin by MK2 Impairs AU-Rich Element mRNA Decay by Preventing Deadenylase Recruitment

(2010) S. L. Clement et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization

(2010) H. Christian Reinhardt et al.   MOLECULAR CELL

Distinct roles for Caf1, Ccr4, Edc3 and CutA in the co-ordination of transcript deadenylation, decapping and P-body formation inAspergillus nidulans

(2010) Igor Y. Morozov et al.   MOLECULAR MICROBIOLOGY

Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo

(2010) Christel Rouget et al.   NATURE

Phosphorylation of Not4p Functions Parallel to BUR2 to Regulate Resistance to Cellular Stresses in Saccharomyces cerevisiae

(2010) Nga-Chi Lau et al.   PLoS One

MicroRNA-122 Modulates the Rhythmic Expression Profile of the Circadian Deadenylase Nocturnin in Mouse Liver

(2010) Shihoko Kojima et al.   PLoS One

NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs

(2010) Atsushi Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of deadenylation-dependent decay

(2010) Chyi-Ying A. Chen et al.   Wiley Interdisciplinary Reviews-RNA

Control of poly(A) tail length

(2010) Christian R. Eckmann et al.   Wiley Interdisciplinary Reviews-RNA

Human Ccr4–Not complexes contain variable deadenylase subunits

(2009) Nga-Chi Lau et al.   BIOCHEMICAL JOURNAL

Regulating the Regulators: Posttranslational Modifications of RNA Silencing Factors

(2009) Inha Heo et al.   CELL

Phosphorylation Dynamics during Early Differentiation of Human Embryonic Stem Cells

(2009) Dennis Van Hoof et al.   Cell Stem Cell

Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs

(2009) Vidya Balagopal et al.   CURRENT OPINION IN CELL BIOLOGY

Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance

(2009) Gaurang P. Deshpande et al.   DNA REPAIR

Conformational stability and multistate unfolding of poly(A)-specific ribonuclease

(2009) Guang-Jun He et al.   FEBS Journal

The Ccr4-Pop2-NOT mRNA Deadenylase Contributes to Septin Organization in Saccharomyces cerevisiae

(2009) Ana Traven et al.   GENETICS

Recognition of Adenosine Residues by the Active Site of Poly(A)-specific Ribonuclease

(2009) Niklas Henriksson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the Antiproliferative Activity of the Tob-hCaf1 Complex

(2009) Masataka Horiuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ccr4–Not Deadenylase Subunits CNOT7 and CNOT8 Have Overlapping Roles and Modulate Cell Proliferation

(2009) Akhmed Aslam et al.   MOLECULAR BIOLOGY OF THE CELL

Arabidopsis Deadenylases AtCAF1a and AtCAF1b Play Overlapping and Distinct Roles in Mediating Environmental Stress Responses

(2009) J. W. Walley et al.   PLANT PHYSIOLOGY

The activity and selectivity of fission yeast Pop2p are affected by a high affinity for Zn2+ and Mn2+ in the active site

(2009) K. R. Andersen et al.   RNA

Structural Basis of m7GpppG Binding to Poly(A)-Specific Ribonuclease

(2009) Mousheng Wu et al.   STRUCTURE

BTG/TOB factors impact deadenylases

(2009) Fabienne Mauxion et al.   TRENDS IN BIOCHEMICAL SCIENCES

To localize or not to localize: mRNA fate is in 3′UTR ends

(2009) Catia Andreassi et al.   TRENDS IN CELL BIOLOGY

Allosteric regulation of human poly(A)-specific ribonuclease by cap and potassium ions

(2008) Wei-Feng Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Arabidopsis homologs of CCR4-associated factor 1 show mRNA deadenylation activity and play a role in plant defence responses

(2008) Wenxing Liang et al.   CELL RESEARCH

3′ end mRNA processing: molecular mechanisms and implications for health and disease

(2008) Sven Danckwardt et al.   EMBO JOURNAL

Finishing touches: Post-translational modification of protein factors involved in mammalian pre-mRNA 3′ end formation

(2008) Kevin Ryan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells

(2008) Dinghai Zheng et al.   JOURNAL OF CELL BIOLOGY

A role for Q/N-rich aggregation-prone regions in P-body localization

(2008) M. A. M. Reijns et al.   JOURNAL OF CELL SCIENCE

Drosophila Maternal Hsp83 mRNA Destabilization Is Directed by Multiple SMAUG Recognition Elements in the Open Reading Frame

(2008) J. L. Semotok et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome wide expression analysis of the CCR4-NOT complex indicates that it consists of three modules with the NOT module controlling SAGA-responsive genes

(2008) Yajun Cui et al.   MOLECULAR GENETICS AND GENOMICS

Multifunctional deadenylase complexes diversify mRNA control

(2008) Aaron C. Goldstrohm et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biophysical and biochemical characterization of recombinant human Pop2 deadenylase

(2008) Wei-Feng Liu et al.   PROTEIN EXPRESSION AND PURIFICATION