Role of the Microenvironment in Regulating Normal and Cancer Stem Cell Activity: Implications for Breast Cancer Progression and Therapy Response

Cancer Stem Cells: The Architects of the Tumor Ecosystem

(2019) Briana C. Prager et al.   Cell Stem Cell

Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition

(2019) Yoko Katsuno et al.   Science Signaling

Extracellular matrix-mediated regulation of cancer stem cells and chemoresistance

(2019) Yazmin Brown et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Hypoxia‐induced secretion stimulates breast cancer stem cell regulatory signalling pathways

(2019) Hanna Jacobsson et al.   Molecular Oncology

Exosomes secreted by mesenchymal stromal/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway

(2019) Shihua Wang et al.   Stem Cell Research & Therapy

Single-Cell Transcriptome Analysis Reveals Estrogen Signaling Coordinately Augments One-Carbon, Polyamine, and Purine Synthesis in Breast Cancer

(2019) Detu Zhu et al.   Cell Reports

Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells

(2019) Yanding Zhao et al.   BMC Medical Genomics

Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer

(2019) Yulia Liubomirski et al.   Frontiers in Immunology

Cancer stem cells in triple-negative breast cancer: a potential target and prognostic marker

(2018) Christopher J O'Conor et al.   Biomarkers in Medicine

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

(2018) Shicheng Su et al.   CELL

Transcriptome Characterization of Matched Primary Breast and Brain Metastatic Tumors to Detect Novel Actionable Targets

(2018) Damir Varešlija et al.   JNCI-Journal of the National Cancer Institute

Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland

(2018) Anna M. Lilja et al.   NATURE CELL BIOLOGY

Publisher Correction: Early lineage segregation of multipotent embryonic mammary gland progenitors

(2018) Aline Wuidart et al.   NATURE CELL BIOLOGY

Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

(2018) Rumela Chakrabarti et al.   SCIENCE

Tumor-associated macrophage-derived cytokines enhance cancer stem-like characteristics through epithelial–mesenchymal transition

(2018) Yongxu Chen et al.   OncoTargets and Therapy

Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer

(2018) Aurélie S. Cazet et al.   Nature Communications

Transcriptome Characterization of Matched Primary Breast and Brain Metastatic Tumors to Detect Novel Actionable Targets

(2018) Damir Varešlija et al.   JNCI-Journal of the National Cancer Institute

Breast Cancers Activate Stromal Fibroblast-Induced Suppression of Progenitors in Adjacent Normal Tissue

(2018) Sumanta Chatterjee et al.   Stem Cell Reports

Cancer Stem Cells, Bone and Tumor Microenvironment: Key Players in Bone Metastases

(2018) Ilaria Roato et al.   Cancers

Adipose-derived stem cells enhance human breast cancer growth and cancer stem cell-like properties through adipsin

(2018) Hideaki Goto et al.   ONCOGENE

C/EBPδ links IL-6 and HIF-1 signaling to promote breast cancer stem cell-associated phenotypes

(2018) Kuppusamy Balamurugan et al.   ONCOGENE

Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment

(2018) Jie Lan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF-2α promotes conversion to a stem cell phenotype and induces chemoresistance in breast cancer cells by activating Wnt and Notch pathways

(2018) Yuanyuan Yan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Senescent Breast Luminal Cells Promote Carcinogenesis through Interleukin-8-Dependent Activation of Stromal Fibroblasts

(2018) Huda H. Al-Khalaf et al.   MOLECULAR AND CELLULAR BIOLOGY

Toward understanding cancer stem cell heterogeneity in the tumor microenvironment

(2018) Federico Bocci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breast Tumor Microenvironment Can Transform Naïve Mesenchymal Stem Cells into Tumor Forming Cells in Nude Mice

(2018) Philipp M Wörner et al.   STEM CELLS AND DEVELOPMENT

Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

(2018) Michael Bartoschek et al.   Nature Communications

The Crosstalk between Cancer Stem Cells and Microenvironment Is Critical for Solid Tumor Progression: The Significant Contribution of Extracellular Vesicles

(2018) Chiara Ciardiello et al.   Stem Cells International

Metastatic Breast Cancer Cells Enter Into Dormant State and Express Cancer Stem Cells Phenotype Under Chronic Hypoxia

(2017) Alessandra Carcereri de Prati et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Intratumor Heterogeneity: Novel Approaches for Resolving Genomic Architecture and Clonal Evolution

(2017) Ravi G. Gupta et al.   MOLECULAR CANCER RESEARCH

Soluble bone-derived osteopontin promotes migration and stem-like behavior of breast cancer cells

(2017) Graciella M. Pio et al.   PLoS One

Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells

(2017) Chen Zhao et al.   SCIENCE

Mammary Stem Cells: Premise, Properties, and Perspectives

(2017) Bethan Lloyd-Lewis et al.   TRENDS IN CELL BIOLOGY

Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells

(2017) Zhengda Sun et al.   Oncotarget

Mesenchymal stem cells from tumor microenvironment favour breast cancer stem cell proliferation, cancerogenic and metastatic potential, via ionotropic purinergic signalling

(2017) A. Maffey et al.   Scientific Reports

Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells

(2017) Hiroyuki Ogawa et al.   Scientific Reports

Impact of the physical microenvironment on tumor progression and metastasis

(2016) Fabian Spill et al.   CURRENT OPINION IN BIOTECHNOLOGY

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

Pygo2 activates MDR1 expression and mediates chemoresistance in breast cancer via the Wnt/β-catenin pathway

(2016) Z-M Zhang et al.   ONCOGENE

Microenvironmental networks promote tumor heterogeneity and enrich for metastatic cancer stem-like cells in Luminal-A breast tumor cells

(2016) Polina Weitzenfeld et al.   Oncotarget

The concept of immune surveillance against tumors: The first theories

(2016) Domenico Ribatti   Oncotarget

Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation

(2016) Rosa Divella et al.   Journal of Cancer

Targeting exosomes from preadipocytes inhibits preadipocyte to cancer stem cell signaling in early-stage breast cancer

(2015) Ramkishore Gernapudi et al.   BREAST CANCER RESEARCH AND TREATMENT

Mammary gland development: cell fate specification, stem cells and the microenvironment

(2015) J. L. Inman et al.   DEVELOPMENT

The first five years of single-cell cancer genomics and beyond

(2015) Nicholas E. Navin   GENOME RESEARCH

Role of TGFβ in regulation of the tumor microenvironment and drug delivery (Review)

(2015) PANAGIOTIS PAPAGEORGIS et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Of Mice and Women: A Comparative Tissue Biology Perspective of Breast Stem Cells and Differentiation

(2015) Gabriela Dontu et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis

(2015) Bo Ri Seo et al.   Science Translational Medicine

Single-Cell Analysis in Cancer Genomics

(2015) Assieh Saadatpour et al.   TRENDS IN GENETICS

Interaction Between Breast Cancer Cells and Adipose Tissue Cells Derived from Fat Grafting

(2015) Michela Massa et al.   Aesthetic Surgery Journal

Tumor Twitter: Cellular Communication in the Breast Cancer Stem Cell Niche

(2015) M. D. Brooks et al.   Cancer Discovery

Adipocytes promote prostate cancer stem cell self-renewal through amplification of the cholecystokinin autocrine loop

(2015) Kai-Dun Tang et al.   Oncotarget

Lung-Derived Factors Mediate Breast Cancer Cell Migration through CD44 Receptor-Ligand Interactions in a Novel Ex Vivo System for Analysis of Organ-Specific Soluble Proteins

(2015) Jenny E. Chu et al.   NEOPLASIA

Enriched CD44+/CD24− population drives the aggressive phenotypes presented in triple-negative breast cancer (TNBC)

(2014) Fei Ma et al.   CANCER LETTERS

Metastatic Stem Cells: Sources, Niches, and Vital Pathways

(2014) Thordur Oskarsson et al.   Cell Stem Cell

Cellular and physical mechanisms of branching morphogenesis

(2014) Victor D. Varner et al.   DEVELOPMENT

Clonal evolution in breast cancer revealed by single nucleus genome sequencing

(2014) Yong Wang et al.   NATURE

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages

(2014) Haihui Lu et al.   NATURE CELL BIOLOGY

Mesenchymal Stem Cell-Induced Doxorubicin Resistance in Triple Negative Breast Cancer

(2014) Dar-Ren Chen et al.   Biomed Research International

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

(2014) Suling Liu et al.   Stem Cell Reports

Regulation of angiogenesis via Notch signaling in breast cancer and cancer stem cells

(2013) Weiqiang Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Inflammation and cancer stem cells

(2013) Sarah Shigdar et al.   CANCER LETTERS

HER2 Drives Luminal Breast Cancer Stem Cells in the Absence of HER2 Amplification: Implications for Efficacy of Adjuvant Trastuzumab

(2013) S. Ithimakin et al.   CANCER RESEARCH

A Role for Matrix Metalloproteinases in Regulating Mammary Stem Cell Function via the Wnt Signaling Pathway

(2013) Kai Kessenbrock et al.   Cell Stem Cell

Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells

(2013) Seog-Young Kim et al.   CELLULAR SIGNALLING

The hemopexin domain of MMP3 is responsible for mammary epithelial invasion and morphogenesis through extracellular interaction with HSP90 

(2013) A. L. Correia et al.   GENES & DEVELOPMENT

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Mapping genetic alterations causing chemoresistance in cancer: identifying the roads by tracking the drivers

(2013) P E Lønning et al.   ONCOGENE

Embryonic Stem Cells Are Redirected to Non-Tumorigenic Epithelial Cell Fate by Interaction with the Mammary Microenvironment

(2013) Corinne A. Boulanger et al.   PLoS One

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

(2013) L. M. Coussens et al.   SCIENCE

Mesenchymal Stem Cells Directly Interact with Breast Cancer Cells and Promote Tumor Cell Growth In Vitro and In Vivo

(2013) Katharina Mandel et al.   STEM CELLS AND DEVELOPMENT

Developmental Changes in the in Vitro Activated Regenerative Activity of Primitive Mammary Epithelial Cells

(2013) Maisam Makarem et al.   PLOS BIOLOGY

CCL2 Mediates Cross-talk between Cancer Cells and Stromal Fibroblasts That Regulates Breast Cancer Stem Cells

(2012) A. Tsuyada et al.   CANCER RESEARCH

Targeting CXCR1/2 Significantly Reduces Breast Cancer Stem Cell Activity and Increases the Efficacy of Inhibiting HER2 via HER2-Dependent and -Independent Mechanisms

(2012) J. K. Singh et al.   CLINICAL CANCER RESEARCH

Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population

(2012) Hasan Korkaya et al.   MOLECULAR CELL

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

(2012) S. J. Conley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?

(2012) Andrew Jarnicki et al.   Cell Division

Myoepithelial Cell Contraction and Milk Ejection Are Impaired in Mammary Glands of Mice Lacking Smooth Muscle Alpha-Actin1

(2011) Carol J. Haaksma et al.   BIOLOGY OF REPRODUCTION

A Dynamic Inflammatory Cytokine Network in the Human Ovarian Cancer Microenvironment

(2011) H. Kulbe et al.   CANCER RESEARCH

Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks

(2011) Suling Liu et al.   CANCER RESEARCH

Multidrug Efflux Pumps and Cancer Stem Cells: Insights Into Multidrug Resistance and Therapeutic Development

(2011) K Moitra et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Breast cancer stem cells, cytokine networks, and the tumor microenvironment

(2011) Hasan Korkaya et al.   JOURNAL OF CLINICAL INVESTIGATION

Cells of origin in cancer

(2011) Jane E. Visvader   NATURE

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Functional Heterogeneity of Breast Fibroblasts Is Defined by a Prostaglandin Secretory Phenotype that Promotes Expansion of Cancer-Stem Like Cells

(2011) Jenny A. Rudnick et al.   PLoS One

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

(2011) D. Iliopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mouse Mammary Microenvironment Redirects Mesoderm-Derived Bone Marrow Cells to a Mammary Epithelial Progenitor Cell Fate

(2011) Corinne A. Boulanger et al.   STEM CELLS AND DEVELOPMENT

Alternatively Activated Macrophages and Collagen Remodeling Characterize the Postpartum Involuting Mammary Gland across Species

(2010) Jenean O'Brien et al.   AMERICAN JOURNAL OF PATHOLOGY

Impact of the hypoxic tumor microenvironment on the regulation of cancer stem cell characteristics

(2010) Qun Lin et al.   CANCER BIOLOGY & THERAPY

Human Bone Marrow-Derived MSCs Can Home to Orthotopic Breast Cancer Tumors and Promote Bone Metastasis

(2010) R. H. Goldstein et al.   CANCER RESEARCH

BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells

(2010) Gemma Molyneux et al.   Cell Stem Cell

Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture

(2010) Yi Arial Zeng et al.   Cell Stem Cell

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell

Cancer Stem Cells and Self-renewal

(2010) C. A. O'Brien et al.   CLINICAL CANCER RESEARCH

The cancer stem cell paradigm: a new understanding of tumor development and treatment

(2010) Johnathan D Ebben et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

(2010) Christophe Ginestier et al.   JOURNAL OF CLINICAL INVESTIGATION

Normal stem cells and cancer stem cells: similar and different

(2010) Mark Shackleton   SEMINARS IN CANCER BIOLOGY

Stem Cells in the Human Breast

(2010) O. W. Petersen et al.   Cold Spring Harbor Perspectives in Biology

Integrins and Extracellular Matrix in Mechanotransduction

(2010) M. A. Schwartz   Cold Spring Harbor Perspectives in Biology

A novel orthotopic and metastatic mouse model of breast cancer in human mammary microenvironment

(2009) Jue Wang et al.   BREAST CANCER RESEARCH AND TREATMENT

Immune-Induced Epithelial to Mesenchymal Transition In vivo Generates Breast Cancer Stem Cells

(2009) M. Santisteban et al.   CANCER RESEARCH

Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

(2009) Emmanuelle Charafe-Jauffret et al.   CANCER RESEARCH

Tissue-resident stem cells promote breast cancer growth and metastasis

(2009) Fabian L. Muehlberg et al.   CARCINOGENESIS

Autocrine TGF-β Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors

(2009) Hiroaki Ikushima et al.   Cell Stem Cell

Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis

(2009) Jennifer N. Lilla et al.   DEVELOPMENTAL BIOLOGY

The in vivo life span of normal and preneoplastic mouse mammary glands: a serial transplantation study

(2009) Charles W. Daniel et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells

(2009) N J Sullivan et al.   ONCOGENE

Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments

(2008) Mark A. LaBarge et al.   Integrative Biology

Hyaluronan-CD44 Interaction Activates Stem Cell Marker Nanog, Stat-3-mediated MDR1 Gene Expression, and Ankyrin-regulated Multidrug Efflux in Breast and Ovarian Tumor Cells

(2008) Lilly Y. W. Bourguignon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Implications of the Cancer Stem-Cell Hypothesis for Breast Cancer Prevention and Therapy

(2008) Madhuri Kakarala et al.   JOURNAL OF CLINICAL ONCOLOGY

β1 Integrin deletion from the basal compartment of the mammary epithelium affects stem cells

(2008) Ilaria Taddei et al.   NATURE CELL BIOLOGY

A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability

(2008) Peter Eirew et al.   NATURE MEDICINE

The role of oxygen availability in embryonic development and stem cell function

(2008) M. Celeste Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion

(2008) H Korkaya et al.   ONCOGENE

Mechanisms of Disease: cancer stem cells—targeting the evil twin

(2008) Andreas Trumpp et al.   Nature clinical practice. Oncology