Heterogeneity of HBV-Specific CD8+ T-Cell Failure: Implications for Immunotherapy

Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

(2019) Anita Schuch et al.   GUT

Anti-PD-1 Blockade with Nivolumab with and without Therapeutic Vaccination for Virally Suppressed Chronic Hepatitis B: A Pilot Study

(2019) Edward Gane et al.   JOURNAL OF HEPATOLOGY

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

(2019) Francesca Alfei et al.   NATURE

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

(2019) Omar Khan et al.   NATURE

Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection

(2019) Chen Yao et al.   NATURE IMMUNOLOGY

Epigenetic signature of PD-1+ TCF1+ CD8 T cells that act as resource cells during chronic viral infection and respond to PD-1 blockade

(2019) Rohit R. Jadhav et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

(2018) Bertram Bengsch et al.   IMMUNITY

Intrahepatic Cross-Presentation and Hepatocellular Antigen Presentation Play Distinct Roles in the Induction of HBV-Specific CD8+ T Cell Responses

(2018) Yasuhiro Murata et al.   JOURNAL OF VIROLOGY

Phenotype and function of HBV-specific T cells is determined by the targeted epitope in addition to the stage of infection

(2018) Ruben C Hoogeveen et al.   GUT

Spatio-temporal differences in presentation of CD8 T cell epitopes during HBV infection.

(2018) Atefeh Khakpoor et al.   JOURNAL OF VIROLOGY

Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection

(2017) Janine Kah et al.   JOURNAL OF CLINICAL INVESTIGATION

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

(2017) Anthony B El-Khoueiry et al.   LANCET

Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B

(2017) Paola Fisicaro et al.   NATURE MEDICINE

TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation

(2017) Dominik Wieland et al.   Nature Communications

Hepatitis B Virus–Specific and Global T-Cell Dysfunction in Chronic Hepatitis B

(2016) Jang-June Park et al.   GASTROENTEROLOGY

T Cell Factor 1-Expressing Memory-like CD8 + T Cells Sustain the Immune Response to Chronic Viral Infections

(2016) Daniel T. Utzschneider et al.   IMMUNITY

Randomized phase II study of GS-4774 as a therapeutic vaccine in virally suppressed patients with chronic hepatitis B

(2016) Anna S. Lok et al.   JOURNAL OF HEPATOLOGY

Adaptive immunity in HBV infection

(2016) Antonio Bertoletti et al.   JOURNAL OF HEPATOLOGY

Demethylation of the PD-1 Promoter Is Imprinted during the Effector Phase of CD8 T Cell Exhaustion

(2016) Eunseon Ahn et al.   JOURNAL OF VIROLOGY

Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

(2016) Ran He et al.   NATURE

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

The epigenetic landscape of T cell exhaustion

(2016) D. R. Sen et al.   SCIENCE

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

(2016) K. E. Pauken et al.   SCIENCE

Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host

(2016) Anna Schurich et al.   Cell Reports

Current treatments for chronic hepatitis B virus infections

(2016) Fabien Zoulim et al.   Current Opinion in Virology

Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities

(2015) Robert G. Gish et al.   ANTIVIRAL RESEARCH

The effect of therapeutic vaccination for the treatment of chronic hepatitis B virus infection

(2015) Yun Bin Lee et al.   JOURNAL OF MEDICAL VIROLOGY

T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance

(2015) B Ye et al.   Cell Death & Disease

Dysfunctional CD8+T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction

(2014) Peter D. Kurktschiev et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation

(2014) Bertram Bengsch et al.   JOURNAL OF HEPATOLOGY

Epigenetic Manipulation Restores Functions of Defective CD8+ T Cells From Chronic Viral Infection

(2014) Fuqin Zhang et al.   MOLECULAR THERAPY

Inhibitory Phenotype of HBV-Specific CD4+ T-Cells Is Characterized by High PD-1 Expression but Absent Coregulation of Multiple Inhibitory Molecules

(2014) Bijan Raziorrouh et al.   PLoS One

T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection

(2014) Marcus Buggert et al.   PLoS Pathogens

Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: Experiences and findings

(2013) Dao-Zhen Xu et al.   JOURNAL OF HEPATOLOGY

Immunological and Antiviral Responses After Therapeutic DNA Immunization in Chronic Hepatitis B Patients Efficiently Treated by Analogues

(2013) O Godon et al.   MOLECULAR THERAPY

Blockade of Tim-3 signaling restores the virus-specific CD8+T-cell response in patients with chronic hepatitis B

(2012) Wei Wu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Restored Function of HBV-Specific T Cells After Long-term Effective Therapy With Nucleos(t)ide Analogues

(2012) Carolina Boni et al.   GASTROENTEROLOGY

IL-10-Producing Regulatory B Cells in the Pathogenesis of Chronic Hepatitis B Virus Infection

(2012) A. Das et al.   JOURNAL OF IMMUNOLOGY

Upregulation of the Tim-3/Galectin-9 Pathway of T Cell Exhaustion in Chronic Hepatitis B Virus Infection

(2012) Gaia Nebbia et al.   PLoS One

Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection

(2012) M. A. Paley et al.   SCIENCE

Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection

(2011) Anna Schurich et al.   HEPATOLOGY

The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function

(2010) Bijan Raziorrouh et al.   HEPATOLOGY

Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1

(2010) Xinyuan Zhou et al.   IMMUNITY

Coexpression of PD-1, 2B4, CD160 and KLRG1 on Exhausted HCV-Specific CD8+ T Cells Is Linked to Antigen Recognition and T Cell Differentiation

(2010) Bertram Bengsch et al.   PLoS Pathogens

Antiviral Intrahepatic T-Cell Responses Can Be Restored by Blocking Programmed Death-1 Pathway in Chronic Hepatitis B

(2009) Paola Fisicaro et al.   GASTROENTEROLOGY

The Size of the Viral Inoculum Contributes to the Outcome of Hepatitis B Virus Infection

(2009) S. Asabe et al.   JOURNAL OF VIROLOGY

Immune effectors required for hepatitis B virus clearance

(2009) P. L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HBV-Specific Adaptive Immunity

(2009) Antonio Bertoletti et al.   Viruses-Basel

Bim-mediated deletion of antigen-specific CD8+ T cells in patients unable to control HBV infection

(2008) A. Ross Lopes et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection

(2008) Abhishek Das et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Selective expansion of a subset of exhausted CD8 T cells by  PD-L1 blockade

(2008) S. D. Blackburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA