Journal
CANCER LETTERS
Volume 320, Issue 1, Pages 1-13Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.01.031
Keywords
Skin; UVB; Skin cancer; Bcl-2 family; Apoptosis
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Funding
- Federal Belgian Government [G.0418.08, P6/18]
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Skin cancer has reached epidemic proportions and is considered to be a direct consequence of ultraviolet (UV) radiation exposure. Excessive exposure of epidermal cells to UV results in apoptosis of irreparably damaged cells to avoid malignant transformation. The Bcl-2 family of proteins is emerging as a crucial regulator of epidermal homeostasis and cell's fate in the stressed skin. Not surprisingly, deregulation of Bcl-2 family members is also chiefly involved in skin carcinogenesis and response to cancer therapy. Here we discuss the physiopathological role of epidermal Bcl-2 family members, their implications in skin carcinogenesis and as potential targets in cancer therapy. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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