The Medial Septum Is Insulin Resistant in the AD Presymptomatic Phase: Rescue by Nerve Growth Factor-Driven IRS1 Activation
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Medial Septum Is Insulin Resistant in the AD Presymptomatic Phase: Rescue by Nerve Growth Factor-Driven IRS1 Activation
Authors
Keywords
Basal forebrain cholinergic neurons, Brain insulin resistance, Alzheimer’s disease, NGF, IRS1
Journal
MOLECULAR NEUROBIOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2018-05-07
DOI
10.1007/s12035-018-1038-4
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease
- (2017) Ramon Velazquez et al. NEUROBIOLOGY OF AGING
- The Input-Output Relationship of the Cholinergic Basal Forebrain
- (2017) Matthew R. Gielow et al. Cell Reports
- Subcortical Shape Changes, Hippocampal Atrophy and Cortical Thinning in Future Alzheimer's Disease Patients
- (2017) Andrea M. Kälin et al. Frontiers in Aging Neuroscience
- Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents
- (2017) Nadia Canu et al. Frontiers in Molecular Neuroscience
- NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease
- (2016) Viviana Triaca et al. AGING CELL
- Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I
- (2016) Ana M. Fernandez et al. DIABETES
- Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline
- (2016) Elizabeth C. Ballinger et al. NEURON
- Reference and working memory deficits in the 3xTg-AD mouse between 2 and 15-months of age: A cross-sectional study
- (2015) Leanne M. Stevens et al. BEHAVIOURAL BRAIN RESEARCH
- Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer’s disease
- (2015) Alaina Baker-Nigh et al. BRAIN
- Alterations in synaptic plasticity coincide with deficits in spatial working memory in presymptomatic 3xTg-AD mice
- (2015) Jason K. Clark et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Insulin resistance-induced hyperglycemia decreased the activation of Akt/CREB in hippocampus neurons: Molecular evidence for mechanism of diabetes-induced cognitive dysfunction
- (2015) Qiong Xiang et al. NEUROPEPTIDES
- Modulation of Hippocampal Neural Plasticity by Glucose-Related Signaling
- (2015) Marco Mainardi et al. NEURAL PLASTICITY
- Insulin Regulates the Activity of the High-Affinity Choline Transporter CHT
- (2015) Katherine J. Fishwick et al. PLoS One
- THE 3XTG-AD MOUSE MODEL OF ALZHEIMER'S DISEASE EXHIBITS AGE-DEPENDENT IMPAIRED GLUCOSE TOLERANCE
- (2014) Milene Vandal et al. Alzheimers & Dementia
- Insulin Action in Brain Regulates Systemic Metabolism and Brain Function
- (2014) A. Kleinridders et al. DIABETES
- The Temporal Pattern of cfos Activation in Hypothalamic, Cortical, and Brainstem Nuclei in Response to Fasting and Refeeding in Male Mice
- (2014) Qunli Wu et al. ENDOCRINOLOGY
- GLUT2-Mediated Glucose Uptake and Availability Are Required for Embryonic Brain Development in Zebrafish
- (2014) Rubén Marín-Juez et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Nerve growth factor metabolic dysfunction in Alzheimer's disease and Down syndrome
- (2014) M. Florencia Iulita et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Insulin in the Brain: Its Pathophysiological Implications for States Related with Central Insulin Resistance, Type 2 Diabetes and Alzheimer’s Disease
- (2014) Enrique Blázquez et al. Frontiers in Endocrinology
- Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
- (2013) Jessica Freiherr et al. CNS DRUGS
- Nerve Growth Factor Receptor TrkA, a New Receptor in Insulin Signaling Pathway in PC12 Cells
- (2013) Thangiah Geetha et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Acetyl-CoA the Key Factor for Survival or Death of Cholinergic Neurons in Course of Neurodegenerative Diseases
- (2013) Andrzej Szutowicz et al. NEUROCHEMICAL RESEARCH
- Intranasal Administration of CNS Therapeutics to Awake Mice
- (2013) Leah R. Hanson et al. Jove-Journal of Visualized Experiments
- Contribution of serine racemase/d-serine pathway to neuronal apoptosis
- (2012) Simona Esposito et al. AGING CELL
- Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
- (2012) K. D. Copps et al. DIABETOLOGIA
- An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
- (2012) Theresa R. Bomfim et al. JOURNAL OF CLINICAL INVESTIGATION
- Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
- (2012) Konrad Talbot et al. JOURNAL OF CLINICAL INVESTIGATION
- Loss of NGF-TrkA Signaling from the CNS Is Not Sufficient to Induce Cognitive Impairments in Young Adult or Intermediate-Aged Mice
- (2012) M. Muller et al. JOURNAL OF NEUROSCIENCE
- Regulation of glucose transport by insulin: traffic control of GLUT4
- (2012) Dara Leto et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
- (2012) Marina R. Picciotto et al. NEURON
- Insulin in the brain: There and back again
- (2012) William A. Banks et al. PHARMACOLOGY & THERAPEUTICS
- Cortical Neurons Develop Insulin Resistance and Blunted Akt Signaling: A Potential Mechanism Contributing to Enhanced Ischemic Injury in Diabetes
- (2011) Bhumsoo Kim et al. ANTIOXIDANTS & REDOX SIGNALING
- Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism
- (2011) V. Ott et al. DIABETES OBESITY & METABOLISM
- Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimerʼs Disease
- (2011) Suzanne M. de la Monte DRUGS
- Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models
- (2010) Rachel M. Nicholson et al. BRAIN RESEARCH
- Cell Signaling by Receptor Tyrosine Kinases
- (2010) Mark A. Lemmon et al. CELL
- Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice
- (2010) Sylvia E. Perez et al. NEUROBIOLOGY OF DISEASE
- -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin
- (2009) Q.-L. Ma et al. JOURNAL OF NEUROSCIENCE
- Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3β signaling pathways and changes in protein expression
- (2008) Ana I. Duarte et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease
- (2008) Leah R Hanson et al. BMC NEUROSCIENCE
- Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications
- (2008) Elliott J Mufson et al. Expert Review of Neurotherapeutics
- Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
- (2008) Aileen M. Moloney et al. NEUROBIOLOGY OF AGING
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now