Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health

Structural evidence of quercetin multi-target bioactivity: A reverse virtual screening strategy

(2017) Diego Carvalho et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways

(2017) Marisa Granato et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis

(2017) Gabriela Carrasco-Torres et al.   Oxidative Medicine and Cellular Longevity

Investigation of the anti-cancer effect of quercetin on HepG2 cells in vivo

(2017) Jin Zhou et al.   PLoS One

Targeting Inflammation in Cancer Prevention and Therapy

(2016) J. Todoric et al.   Cancer Prevention Research

Quercetin alters the DNA damage response in human hematopoietic stem and progenitor cellsviaTopoII- and PI3K-dependent mechanisms synergizing in leukemogenic rearrangements

(2016) Shahar Biechonski et al.   INTERNATIONAL JOURNAL OF CANCER

Combination chemoprevention with grape antioxidants

(2016) Chandra K. Singh et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Quercetin induces caspase-dependent extrinsic apoptosis through inhibition of signal transducer and activator of transcription 3 signaling in HER2-overexpressing BT-474 breast cancer cells

(2016) HYE-SOOK SEO et al.   ONCOLOGY REPORTS

Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy

(2016) Barbara Marengo et al.   Oxidative Medicine and Cellular Longevity

Quercetin, Inflammation and Immunity

(2016) Yao Li et al.   Nutrients

Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?

(2016) Santa Cirmi et al.   Nutrients

Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis

(2016) Shikha Srivastava et al.   Scientific Reports

Quercetin in Cancer Treatment, Alone or in Combination with Conventional Therapeutics?

(2015) Ana Brito et al.   CURRENT MEDICINAL CHEMISTRY

Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling

(2015) Zongyuan Yang et al.   FEBS Journal

Quercetin: A flavonol with multifaceted therapeutic applications?

(2015) Gabriele D'Andrea   FITOTERAPIA

The role for autophagy in cancer

(2015) Eileen White   JOURNAL OF CLINICAL INVESTIGATION

Cancer Prevention: Obstacles, Challenges, and the Road Ahead

(2015) Frank L. Meyskens et al.   JNCI-Journal of the National Cancer Institute

Quercetin regulates β-catenin signaling and reduces the migration of triple negative breast cancer

(2015) Asha Srinivasan et al.   MOLECULAR CARCINOGENESIS

Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death

(2015) JI-HONG MOON et al.   ONCOLOGY REPORTS

Quercetin Affects Hsp70/IRE1αMediated Protection from Death Induced by Endoplasmic Reticulum Stress

(2015) Antonello Storniolo et al.   Oxidative Medicine and Cellular Longevity

Inhibition of autophagy induced by quercetin at a late stage enhances cytotoxic effects on glioma cells

(2015) Yunke Bi et al.   TUMOR BIOLOGY

The critical role of quercetin in autophagy and apoptosis in HeLa cells

(2015) Yijun Wang et al.   TUMOR BIOLOGY

Diet-Based Strategies for Cancer Chemoprevention: The Role of Combination Regimens Using Dietary Bioactive Components

(2015) Christina DiMarco-Crook et al.   Annual Review of Food Science and Technology

Polyphenol Compound as a Transcription Factor Inhibitor

(2015) Seyeon Park   Nutrients

Cancer Prevention: Obstacles, Challenges, and the Road Ahead

(2015) Frank L. Meyskens et al.   JNCI-Journal of the National Cancer Institute

A Potent Inhibitor of Phosphoinositide 3-Kinase (PI3K) and Mitogen Activated Protein (MAP) Kinase Signalling, Quercetin (3, 3', 4', 5, 7-Pentahydroxyflavone) Promotes Cell Death in Ultraviolet (UV)-B-Irradiated B16F10 Melanoma Cells

(2015) Rather A. Rafiq et al.   PLoS One

Flavonoids and Wnt/β-Catenin Signaling: Potential Role in Colorectal Cancer Therapies

(2014) Nathália Amado et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents

(2014) Min Hye Yang et al.   LIFE SCIENCES

Targeting RAS–ERK signalling in cancer: promises and challenges

(2014) Ahmed A. Samatar et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer

(2014) N Hasima et al.   Cell Death & Disease

Editorial (Hot Topic: Inhibition of PI3K/Akt/mTOR Signaling by Natural Products)

(2013) Shile Huang   Anti-Cancer Agents in Medicinal Chemistry

Quercetin Potentiates Apoptosis by Inhibiting Nuclear Factor-kappaB Signaling in H460 Lung Cancer Cells

(2013) HyeSook Youn et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Cancer chemoprevention: a rapidly evolving field

(2013) W P Steward et al.   BRITISH JOURNAL OF CANCER

Molecular mechanisms underlying chronic inflammation-associated cancers

(2013) Yongzhong Wu et al.   CANCER LETTERS

Bioavailability of Quercetin: Problems and Promises

(2013) X. Cai et al.   CURRENT MEDICINAL CHEMISTRY

Quercetin Induces Apoptosis via the Mitochondrial Pathway in KB and KBv200 Cells

(2013) Jian-ye Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Diet and cancer: Risk factors and epidemiological evidence

(2013) Raúl Baena Ruiz et al.   MATURITAS

Structural Basis of the Unfolded Protein Response

(2012) Alexei Korennykh et al.   Annual Review of Cell and Developmental Biology

Influence of Quercetin-Rich Food Intake on microRNA Expression in Lung Cancer Tissues

(2012) T. K. Lam et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling

(2011) Kui Wang et al.   Autophagy

The flavonoid quercetin in disease prevention and therapy: Facts and fancies

(2011) Maria Russo et al.   BIOCHEMICAL PHARMACOLOGY

Proteasome inhibition by quercetin triggers macroautophagy and blocks mTOR activity

(2011) Anja K. Klappan et al.   HISTOCHEMISTRY AND CELL BIOLOGY

UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer

(2011) Gerd P. Pfeifer et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk

(2010) Tram Kim Lam et al.   CARCINOGENESIS

NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3 , C/EBP  and ATF3

(2010) S. H. Lee et al.   CARCINOGENESIS

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Cancer Chemoprevention by Natural Products: How Far Have We Come?

(2010) Rajendra G. Mehta et al.   PHARMACEUTICAL RESEARCH

Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin

(2010) Lara Gibellini et al.   Cancers

Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials

(2009) E. N. Scott et al.   Cancer Prevention Research

Inhibition of reactive oxygen species and pre-neoplastic lesions by quercetin through an antioxidant defense mechanism

(2009) Verónica R. Vásquez-Garzón et al.   FREE RADICAL RESEARCH

Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells

(2009) Su-Yu Chien et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Effects of Quercetin and Catechin on Hepatic Glutathione-S Transferase (GST), NAD(P)H Quinone Oxidoreductase 1 (NQO1), and Antioxidant Enzyme Activity Levels in Rats

(2009) Heike Wiegand et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Stabilization of p53 Is Involved in Quercetin-Induced Cell Cycle Arrest and Apoptosis in HepG2 Cells

(2008) Shunsuke TANIGAWA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Stabilization of Quercetin Paradoxically Reduces Its Proapoptotic Effect on UVB-Irradiated Human Keratinocytes

(2008) E. R. Olson et al.   Cancer Prevention Research

ROS and p53: A versatile partnership

(2008) Bin Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression

(2008) Jae-Hoon Jeong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Quercetin promotes degradation of survivin and thereby enhances death-receptor–mediated apoptosis in glioma cells

(2008) Markus D. Siegelin et al.   NEURO-ONCOLOGY

Cell cycle control as a basis for cancer chemoprevention through dietary agents

(2007) Syed Musthapa Meeran   Frontiers in Bioscience-Landmark