Flavonoids and Wnt/β-Catenin Signaling: Potential Role in Colorectal Cancer Therapies

Silibinin Suppresses Growth of Human Colorectal Carcinoma SW480 Cells in Culture and Xenograft through Down-regulation of β-Catenin-Dependent Signaling

(2015) Manjinder Kaur et al.   NEOPLASIA

Targeting the Tcf4 G13ANDE17 Binding Site To Selectively Disrupt β-Catenin/T-Cell Factor Protein–Protein Interactions

(2013) Zheng Huang et al.   ACS Chemical Biology

A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation-Driven Colorectal Tumor Growth

(2013) T. Lau et al.   CANCER RESEARCH

Effects of Natural Compounds on Xenopus Embryogenesis: A Potential Read Out for Functional Drug Discovery Targeting Wnt/β-catenin Signaling

(2013) Nathalia G. Amado et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Potential Targets for Colorectal Cancer Prevention

(2013) Sally Temraz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of Tankyrase Inhibiting Flavones with Increased Potency and Isoenzyme Selectivity

(2013) Mohit Narwal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epigallocatechin-3-Gallate Inhibits Hepatoblastoma Growth by Reactivating the Wnt Inhibitor SFRP1

(2013) Jan Gödeke et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells

(2013) Licheng He et al.   TOXICOLOGY

Selective Small Molecule Targeting β-Catenin Function Discovered by In Vivo Chemical Genetic Screen

(2013) Jijun Hao et al.   Cell Reports

A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice

(2012) J. Waaler et al.   CANCER RESEARCH

Wnt/beta-Catenin Signaling and Small Molecule Inhibitors

(2012) Andrey Voronkov et al.   CURRENT PHARMACEUTICAL DESIGN

[1,2,4]Triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: Antagonists of the Wnt Pathway That Inhibit Tankyrases 1 and 2 via Novel Adenosine Pocket Binding

(2012) Michael D. Shultz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis of Selective Inhibition of Human Tankyrases

(2012) Mohit Narwal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Structure-Based Discovery of a Novel Inhibitor Targeting the β-Catenin/Tcf4 Interaction

(2011) Wang Tian et al.   BIOCHEMISTRY

The diagnostic value of symptoms for colorectal cancer in primary care: a systematic review

(2011) Margaret Astin et al.   BRITISH JOURNAL OF GENERAL PRACTICE

A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis

(2011) Wei Wang et al.   CELL RESEARCH

Dietary Flavonoids as Cancer Prevention Agents

(2011) HUA YAO et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Citrus Flavonoids Luteolin, Apigenin, and Quercetin Inhibit Glycogen Synthase Kinase-3β Enzymatic Activity by Lowering the Interaction Energy Within the Binding Cavity

(2011) Jodee L. Johnson et al.   JOURNAL OF MEDICINAL FOOD

Flavonoids: Potential Wnt/beta-catenin signaling modulators in cancer

(2011) Nathália G. Amado et al.   LIFE SCIENCES

An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway

(2011) F. C. Gonsalves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatitis B viral X protein interacts with tumor suppressor adenomatous polyposis coli to activate Wnt/β-catenin signaling

(2010) Antony Hsieh et al.   CANCER LETTERS

A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription

(2010) K. Ewan et al.   CANCER RESEARCH

Inhibition of β-catenin/Tcf signaling by flavonoids

(2010) Seyeon Park et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

(2010) Curtis A Thorne et al.   Nature Chemical Biology

Cancer Prevention With Natural Compounds

(2010) Norleena P. Gullett et al.   SEMINARS IN ONCOLOGY

Isoquercitrin isolated from Hyptis fasciculata reduces glioblastoma cell proliferation and changes β-catenin cellular localization

(2009) Nathália G. Amado et al.   ANTI-CANCER DRUGS

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Discovery and Characterization of a Small Molecule Inhibitor of the PDZ Domain of Dishevelled

(2009) David Grandy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Inhibition of Wnt signaling by Dishevelled PDZ peptides

(2009) Yingnan Zhang et al.   Nature Chemical Biology

Molecular Basis of Colorectal Cancer

(2009) Sanford D. Markowitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multitargeted cancer prevention by quercetin

(2008) Akira Murakami et al.   CANCER LETTERS

WIF-1 promoter region hypermethylation as an adjuvant diagnostic marker for non-small cell lung cancer-related malignant pleural effusions

(2008) Tsung-Ming Yang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1

(2008) Keith A. Menear et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficacy of Selected Natural Products as Therapeutic Agents against Cancer⊥

(2008) Sanjeev Banerjee et al.   JOURNAL OF NATURAL PRODUCTS