Article
Medicine, Research & Experimental
Rattanaporn Jaidee, Veerapol Kukongviriyapan, Laddawan Senggunprai, Auemduan Prawan, Apinya Jusakul, Phatthamon Laphanuwat, Sarinya Kongpetch
Summary: Knockdown of FGFR2 suppressed cell growth and colony formation in CCA cells through G2/M cell cycle arrest and downregulation of STAT3, cyclin A, and cyclin B1. Silencing FGFR2 enhanced the suppressive effect of gemcitabine on cell migration and invasion.
Article
Biology
Chao Xu, Qinwen Ye, Chao Ye, Shaojun Liu
Summary: circACTR2 is down-regulated in pancreatic cancer cells and can reverse chemoresistance by inhibiting the PI3K/AKT signaling pathway through sponge miR-221-3p and upregulating PTEN expression.
Article
Medical Laboratory Technology
Zhenfeng Tian, Ying Tan, Xingyi Lin, Mingxin Su, Lele Pan, Lijun Lin, Guangsheng Ou, Yinting Chen
Summary: TIMP1 and p-mTOR are elevated in pancreatic ductal adenocarcinoma (PDAC) patients and are associated with worse overall survival. The TIMP1/PI3K/AKT/mTOR pathway is involved in epithelial-mesenchymal transition and apoptosis, and can be suppressed by the combination of ATO and GEM, leading to sensitization and reversal of GEM resistance. The combination therapy has synergistic anticancer effects in vitro and in vivo.
TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Keisuke Okuno, Caiming Xu, Silvia Pascual-Sabater, Masanori Tokunaga, Haiyong Han, Cristina Fillat, Yusuke Kinugasa, Ajay Goel
Summary: This study shows that Berberine (BBR) can enhance the chemosensitivity of pancreatic ductal adenocarcinoma (PDAC) cells to Gemcitabine (Gem). Cell culture and patient-derived organoid experiments demonstrate that the combination of BBR and Gem has better anti-cancer effects in Gem-resistant PDAC cells. Furthermore, the study reveals that the Rap1/PI3K-Akt signaling pathway plays a key role in BBR-mediated chemosensitization in PDAC.
Article
Oncology
Sheng Wang, Wei Feng, Wulin Wang, Xiaoman Ye, Hao Chen, Chunzhao Yu
Summary: This study aims to increase the sensitivity of gemcitabine chemotherapy for pancreatic cancer by silencing the Girdin gene, showing that Girdin may enhance chemotherapy resistance to gemcitabine through regulating autophagy activity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fangyu Zhao, Gang Yang, Jiangdong Qiu, Yueze Liu, Jinxin Tao, Guangyu Chen, Dan Su, Lei You, Lianfang Zheng, Taiping Zhang, Yupei Zhao
Summary: Pancreatic ductal adenocarcinoma (PDAC) has a poor response to gemcitabine. STC1 regulates chemoresistance in pancreatic cancer and may serve as a potential prognostic factor and therapeutic target for PDAC treatment.
MOLECULAR CARCINOGENESIS
(2022)
Article
Biochemistry & Molecular Biology
Jianyou Gu, Wenjie Huang, Xianxing Wang, Junfeng Zhang, Tian Tao, Yao Zheng, Songsong Liu, Jiali Yang, Zhe-Sheng Chen, Chao-Yun Cai, Jinsui Li, Huaizhi Wang, Yingfang Fan
Summary: This study investigated the potential mechanisms of microRNAs and ABC transporters related signaling pathways for PC resistance to gemcitabine. The results suggest that hsa-miR-3178 promotes gemcitabine resistance via RhoB/PI3K/Akt signaling pathway-mediated upregulation of ABC transporters.
Article
Biochemistry & Molecular Biology
Jing Cui, Yao Guo, Heshui Wu, Jiongxin Xiong, Tao Peng
Summary: The study found that everolimus (Evr) can overcome gemcitabine (GEM) resistance in pancreatic cancer by inhibiting aerobic glycolysis and promoting apoptosis. The therapeutic effect of Evr in GEM-resistant cells was significantly better than in GEM-sensitive cells.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Kai Wu, Hao Chen, Yue Fu, Xiang Cao, Chunzhao Yu
Summary: This study focuses on the role of insulin in the migration and proliferation of pancreatic cancer cells and its molecular mechanisms. It was found that insulin promotes the proliferation and migration of pancreatic cancer cells by up-regulating the expression of PLK1. Inhibition of PLK1 expression can counteract the effects of insulin on the biological behavior of pancreatic cancer cells. Additionally, insulin activates the PI3K/AKT pathway in pancreatic cancer cells, and inhibiting this pathway suppresses PLK1 expression. The findings suggest that the up-regulation of PLK1 by insulin via the PI3K/AKT pathway enhances the migration and proliferation of pancreatic cancer cells, contributing to the poor prognosis of pancreatic cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Jifan Chen, Yuheng Bao, Yue Song, Cong Zhang, Fuqiang Qiu, Yu Sun, Lei Xin, Jing Cao, Yifan Jiang, Jiali Luo, Chao Zhang, Guowei Wang, Qunyin Li, Yajing Liu, Weijun Tong, Pintong Huang
Summary: A nanoplatform was developed to alleviate hypoxia in pancreatic cancer by catalyzing peroxide to oxygen with Pt nanoparticles, releasing drugs quickly in lysosome microenvironment to enhance cancer cell sensitivity to chemotherapy, and converting the produced oxygen into highly cytotoxic singlet oxygen under ultrasound exposure.
Article
Oncology
Kai Lin, Endi Zhou, Ting Shi, Siqing Zhang, Jinfan Zhang, Ziruo Zheng, Yuetian Pan, Wentao Gao, Yabin Yu
Summary: It has been found that fat mass and obesity-associated protein (FTO) plays a regulatory role in chemoresistance in pancreatic cancer. FTO demethylates NEDD4 RNA in a m6A-dependent manner, which then influences the PTEN expression level and affects the PI3K/AKT pathway, leading to the development of drug resistance.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Tianli Zhang, Mengmeng Liu, Qing Liu, Gary Guishan Xiao
Summary: Wogonin can enhance the sensitivity of pancreatic cancer cells to gemcitabine chemotherapy, possibly by promoting apoptosis through inhibiting the Akt signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Shengqin Su, Gagan Chhabra, Chandra K. Singh, Mary A. Ndiaye, Nihal Ahmad
Summary: This review discusses the role of PLK1 in cancer and the advantages of combining PLK1 inhibitors with other drugs for cancer treatment. PLK1 inhibitors in combination with chemotherapy drugs and targeted small molecules have shown superior effects against cancer both in vitro and in vivo. However, further research is needed to identify the best combination targets and drug combinations.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Juan Zhang, Hong-Xi Xu, William Chi Shing Cho, Wah Cheuk, Yang Li, Qiong-Hui Huang, Wen Yang, Yan-Fang Xian, Zhi-Xiu Lin
Summary: This study found that Brucein D (BD) can enhance the chemosensitivity of gemcitabine (GEM) in pancreatic ductal adenocarcinoma (PDAC) by inhibiting the Nrf2 pathway. This discovery provides hope for the further development of BD as a novel adjuvant therapy for PDAC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Yao Guo, Heshui Wu, Jiongxin Xiong, Shanmiao Gou, Jing Cui, Tao Peng
Summary: This study found that miR-222-3p delivered by M2 macrophage-derived extracellular vesicles (M2 MDEs) plays an important role in the chemoresistance of pancreatic cancer (PCa). Co-culture with M2 MDEs enriched with miR-222-3p reduced sensitivity to gemcitabine, promoted proliferation, and suppressed apoptosis in PCa cells. In vivo experiments showed that the injection of miR-222-3p inhibitor by M2 MDEs suppressed tumor growth and increased sensitivity of cancer cells to gemcitabine. Additionally, miR-222-3p was found to inhibit TSC1 expression and activate the PI3K/AKT/mTOR pathway.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)