Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy

Subcellular compartmentalization of proximal Gαq-receptor signaling produces unique hypertrophic phenotypes in adult cardiac myocytes

(2018) Erika F. Dahl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells

(2018) Qingwen Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compartmentalized cyclic nucleotides have opposing effects on regulation of hypertrophic phospholipase Cε signaling in cardiac myocytes

(2018) Craig A. Nash et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process

(2018) David Dickens et al.   MOLECULAR PHARMACEUTICS

A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action

(2018) Miriam Stoeber et al.   NEURON

G-Protein–Coupled Receptors in Heart Disease

(2018) Jialu Wang et al.   CIRCULATION RESEARCH

Functional selectivity of GPCR-directed drug action through location bias

(2017) Roshanak Irannejad et al.   Nature Chemical Biology

Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription

(2017) Amod Godbole et al.   Nature Communications

G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway

(2015) S. Malik et al.   MOLECULAR BIOLOGY OF THE CELL

Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”

(2015) Yingmin Zhu et al.   Scientific Reports

GPCR signaling along the endocytic pathway

(2014) Roshanak Irannejad et al.   CURRENT OPINION IN CELL BIOLOGY

Endosomal generation of cAMP in GPCR signaling

(2014) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

Phospholipase Cε Hydrolyzes Perinuclear Phosphatidylinositol 4-Phosphate to Regulate Cardiac Hypertrophy

(2013) Lianghui Zhang et al.   CELL

Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca2+ in adult cardiac myocytes

(2013) Clémence Merlen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

Altered Cardiac Electrophysiology and SUDEP in a Model of Dravet Syndrome

(2013) David S. Auerbach et al.   PLoS One

Role of phospholipase Cε in physiological phosphoinositide signaling networks

(2012) Alan V. Smrcka et al.   CELLULAR SIGNALLING

Phospholipase Cϵ Scaffolds to Muscle-specific A Kinase Anchoring Protein (mAKAPβ) and Integrates Multiple Hypertrophic Stimuli in Cardiac Myocytes

(2011) Lianghui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase Cβ1b associates with a Shank3 complex at the cardiac sarcolemma

(2010) David R. Grubb et al.   FASEB JOURNAL

Gq-initiated cardiomyocyte hypertrophy is mediated by phospholipase Cβ1b

(2009) Theresa M. Filtz et al.   FASEB JOURNAL

An Adenylyl Cyclase-mAKAPβ Signaling Complex Regulates cAMP Levels in Cardiac Myocytes

(2009) Michael S. Kapiloff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled Receptors

(2009) Davide Calebiro et al.   PLOS BIOLOGY

Nuclear α1-Adrenergic Receptors Signal Activated ERK Localization to Caveolae in Adult Cardiac Myocytes

(2008) Casey D. Wright et al.   CIRCULATION RESEARCH

Activated Nuclear Metabotropic Glutamate Receptor mGlu5 Couples to Nuclear Gq/11Proteins to Generate Inositol 1,4,5-Trisphosphate-mediated Nuclear Ca2+Release

(2008) Vikas Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY