Article
Multidisciplinary Sciences
Edikan A. Ogunnaike, Alain Valdivia, Mostafa Yazdimamaghani, Ernesto Leon, Seema Nandi, Hannah Hudson, Hongwei Du, Simon Khagi, Zhen Gu, Barbara Savoldo, Frances S. Ligler, Shawn Hingtgen, Gianpietro Dotti
Summary: The delivery of CAR-T cells within the surgical cavity using a fibrin-based gel demonstrates superior antitumor activity compared to direct inoculation into the tumor resection cavity in a model of subtotal glioblastoma resection.
Article
Environmental Sciences
Yan Wang, Na Liu, Xiaoquan Huang, Wangcheng Hu, Ying Ma, Ying Liang, Wenjing Xie, Meng Tang
Summary: The study found that exposure to PM SRM1648a increased LC3II expression and autophagosome accumulation in HUVECs, indicating impaired autophagic degradation function. Through experiments and analysis, it was revealed that the detrimental effects of PM SRM1648a on lysosomal function lead to the blockage of autophagic flux, ultimately resulting in endothelial cell damage.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biology
Ani-Simona Sevastre, Carina Baloi, Oana Alexandru, Ligia Gabriela Tataranu, Oana Stefana Popescu, Anica Dricu
Summary: This study evaluated the antiproliferative effects of six azo-dyes and TMZ on human glioblastoma cells and found that azo-dyes showed stronger cytotoxic effects at equimolar concentrations compared to TMZ. Methyl Orange exhibited the highest potency in inhibiting cell growth. These findings suggest that azo-dyes may be a potential source of agents for cancer treatment.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Moli Wu, Danyang Song, Hui Li, Nisar Ahmad, Hong Xu, Xiaobo Yang, Qian Wang, Xiaoxin Cheng, Sa Deng, Xiaohong Shu
Summary: Chemoresistance is a challenge in the treatment of glioblastoma (GBM), and the activity of O6-methylguanine-DNA methyltransferase (MGMT) and signal transducer and of transcription 3 (STAT3) have been linked to GBM resistance. Resveratrol (Res) inhibits tumor growth and improves chemosensitivity by targeting STAT3 signaling. This study found that Res effectively improved chemosensitivity of GBM cells to temozolomide (TMZ) and downregulated STAT3 activity, leading to inhibition of cell proliferation, migration, and induction of apoptosis. The combination therapy of Res and TMZ also reversed TMZ resistance and decreased MGMT and STAT3 levels. Therefore, Res may be an ideal candidate for combined chemotherapy with TMZ in GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Mohummad Aminur Rahman, Agnete S. T. Engelsen, Shahin Sarowar, Christian Bindesboll, Even Birkeland, Dorota Goplen, Maria L. L. Lotsberg, Stian Knappskog, Anne Simonsen, Martha Chekenya
Summary: The study found that bortezomib can enhance the efficacy of temozolomide by inhibiting autophagic flux, thereby increasing the treatment effect on glioblastoma and increasing the occurrence of cell apoptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Ondrej Honc, Jiri Novotny
Summary: It has been found that methadone, a drug containing opioids, can increase the sensitivity of glioblastoma cells to temozolomide by increasing intracellular calcium concentration, oxidative stress, and DNA damage. This study provides evidence for the potential value of methadone in the treatment of glioblastoma with temozolomide and sheds light on the molecular mechanism of synergistic action of these two drugs.
Article
Pharmacology & Pharmacy
Sajid Jalal, Ting Zhang, Jia Deng, Jie Wang, Ting Xu, Tianhua Zhang, Chuanxin Zhai, Ruqiang Yuan, Hongming Teng, Lin Huang
Summary: This study found that LXX-8250 treatment can induce apoptosis in melanoma cells by inhibiting autophagic flux and glycolysis. This effect is mediated by suppression of PFKFB4 expression. The research provides a novel strategy for the treatment of melanoma.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Tetsuya Yamada, Shohei Tsuji, Shinsuke Nakamura, Yusuke Egashira, Masamitsu Shimazawa, Noriyuki Nakayama, Hirohito Yano, Toru Iwama, Hideaki Hara
Summary: Riluzole demonstrates significant growth-inhibitory effects on all GBM cell lines in a time- and dose-dependent manner. It synergistically enhances the antitumor effect of TMZ in MGMT-positive GBM cell lines, while suppressing MGMT expression and TMZ-induced MGMT upregulation. Combinatorial TMZ/riluzole treatment significantly suppresses tumor growth in an intracranial MGMT-positive GBM model, suggesting it as a promising therapeutic regimen for MGMT-positive GBMs.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Michela Campolo, Marika Lanza, Giovanna Casili, Irene Paterniti, Alessia Filippone, Maria Caffo, Salvatore M. Cardali, Ivana Puliafito, Cristina Colarossi, Gabriele Raciti, Salvatore Cuzzocrea, Emanuela Esposito
Summary: The study revealed that 5Z-7-oxozeaenol plays an important role in increasing the sensitivity of glioblastoma cells to chemotherapy, potentially serving as an effective adjuvant to current chemotherapeutic regimens. It also highlighted the continuous involvement of mitogen-activated protein kinase in tumorigenesis following chemotherapy.
Article
Biochemistry & Molecular Biology
Shota Ando, Chiami Moyama, Naoto Kojima, Mitsugu Fujita, Kaito Ohta, Yukina Kohno, Hiromi Ii, Susumu Nakata
Summary: JCI-20679, a mitochondrial complex I inhibitor, enhances the anti-proliferative effects of temozolomide in glioblastoma cells. It inhibits temozolomide-induced autophagy and blocks the increase of ATP levels, leading to improved therapeutic efficacy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
I de Souza, L. K. S. Monteiro, C. B. Guedes, M. M. Silva, M. Andrade-Tomaz, B. Contieri, M. T. Latancia, D. Mendes, B. F. M. M. Porchia, M. Lazarini, L. R. Gomes, C. R. R. Rocha
Summary: The study reveals the role of NRF2 in modulating ferroptosis in glioblastoma cells, as well as its correlation with ABCC1 expression. Moreover, high levels of NRF2 result in collateral sensitivity and contribute to GSH depletion when the system xc(-) is blocked. These findings suggest that ferroptosis induction could be a potential therapeutic strategy to reverse drug resistance in gliomas.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Ying Yu, Wen-Xian Ou-Yang, Hui Zhang, Tao Jiang, Lian Tang, Yan-Fang Tan, Hai-Yan Luo, Zheng-Hui Xiao, Shuang-Jie Li
Summary: The downregulation of miR-125b in septic cardiomyopathy leads to the hyperactivation of STAT3/HMGB1, resulting in excessive ROS generation and impaired autophagic flux, ultimately causing myocardial dysfunction.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Ryan C. Gimple, Guoxin Zhang, Shuai Wang, Tengfei Huang, Jina Lee, Suchet Taori, Deguan Lv, Deobrat Dixit, Matthew E. Halbert, Andrew R. Morton, Reilly L. Kidwell, Zhen Dong, Briana C. Prager, Leo J. Y. Kim, Zhixin Qiu, Linjie Zhao, Qi Xie, Qiulian Wu, Sameer Agnihotri, Jeremy N. Rich
Summary: In this study, the researchers found that SNX10 was selectively expressed in glioblastoma stem cells (GSCs) compared with non-neoplastic neural stem cells (NSCs). SNX10 was essential for GSC survival and promoted GSC proliferation and stem cell signaling pathways through posttranscriptional regulation of PDGFR tyrosine kinase. Targeting SNX10 expression decreased GSC viability and self-renewal capacity. High expression of SNX10 correlated with poor prognosis in glioblastoma patients.
Article
Oncology
Zijin Zhao, Miaomiao Liu, Wenyong Long, Jian Yuan, Haoyu Li, Chi Zhang, Guodong Tang, Weixi Jiang, Xianrui Yuan, Minghua Wu, Qing Liu
Summary: CRNDE is a poor prognosis factor for GBM patients, upregulated in TMZ-resistant patients, and closely associated with chemotherapeutic response to TMZ treatment. Knockdown of CRNDE significantly reduces glioma cell viability and proliferation, enhances cell apoptosis, and improves sensitivity to TMZ treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Eryan Yang, Lin Wang, Weili Jin, Xing Liu, Qixue Wang, Ye Wu, Yanli Tan, Yunfei Wang, Xiaoteng Cui, Jixing Zhao, Fei Tong, Biao Hong, Menglin Xiao, Xiaomin Liu, Chuan Fang, Chunsheng Kang
Summary: This study highlights the importance of PTRF in glioblastoma and its role as a predictor of prognosis in GBM patients treated with temozolomide. It also identifies a novel mechanism contributing to temozolomide resistance. Furthermore, this study provides a new idea for GBM therapy.
Article
Chemistry, Applied
Douglas O. Ochora, Esezah Kakudidi, Jane Namukobe, Matthias Heydenreich, Paolo Coghi, Li Jun Yang, Edwin W. Mwakio, Ben Andagalu, Amanda Roth, Hoseah M. Akala, Vincent K. W. Wong, Abiy Yenesew
Summary: Extracts from Securidaca longipedunculata exhibited antiplasmodial activities against reference clones and clinical isolates, with a new benzophenone and known compounds showing potential anti-malarial properties. However, these compounds also displayed weak activity against cancer cell-lines while being non-toxic to normal cells.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Giovanni Ribaudo, Paolo Coghi, Li Jun Yang, Jerome P. L. Ng, Andrea Mastinu, Maurizio Memo, Vincent Kam Wai Wong, Alessandra Gianoncelli
Summary: The study found that chloroquine binds more efficiently to RBD than artemisinins, which may help combat the novel coronavirus. Artemisinin and its derivatives are also being considered as potential antiviral agents.
NATURAL PRODUCT RESEARCH
(2022)
Review
Medicine, Research & Experimental
Carmen Sze-Ching Lo, Karrie Mei-Yee Kiang, Gilberto Ka-Kit Leung
Summary: Vitamin D demonstrates anti-tumoral activity in glioblastoma by promoting cell death and inhibiting tumor growth, while also reducing cell migration and invasiveness. Upregulation of vitamin D receptors may enhance its anti-tumor effects by its analogs in glioblastoma.
LABORATORY INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Wen-Qiao Qiu, Wei Ai, Feng-Dan Zhu, Yue Zhang, Min-Song Guo, Betty Yuen-Kwan Law, Jian-Ming Wu, Vincent Kam-Wai Wong, Yong Tang, Lu Yu, Qi Chen, Chong-Lin Yu, Jian Liu, Da-Lian Qin, Xiao-Gang Zhou, An-Guo Wu
Summary: This study demonstrates that triterpenoid saponins in Radix Polygalae inhibit the activation of the NLRP3 inflammasome via SHP-2-mediated mitophagy, suggesting therapeutic potential in neurodegenerative diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Medicinal
Bin Tang, Wu Zeng, Lin Lin Song, Hui Miao Wang, Li Qun Qu, Hang Hong Lo, Lu Yu, An Guo Wu, Vincent Kam Wai Wong, Betty Yuen Kwan Law
Summary: Exosomes, nano-sized extracellular vesicles secreted by cells, have been explored as carriers to transport compounds across the blood-brain barrier for targeting the central nervous system. This study compared different methods for loading exosomes with natural compounds of varying molecular weights and investigated their efficacy both in vitro and in vivo. The results showed a positive correlation between the efficiency of compound loading and its molecular weight. Moreover, certain exosome-encapsulated natural compounds were found to effectively reduce levels of neurodegenerative disease mutant proteins. Additionally, exosome-encapsulated-neferine was shown to improve motor deficits and decrease beta-amyloid levels in the brain. This research provides a rationale for using exosomes to target blood-brain barrier permeability and treat neurodegenerative diseases.
Article
Chemistry, Applied
Paolo Coghi, Xiao Yun Yun, Jerome P. L. Ng, Betty Yuan Kwan Law, Maurizio Memo, Alessandra Gianoncelli, Vincent Kam Wai Wong, Giovanni Ribaudo
Summary: This study investigates the interaction of tanshinones with the Delta RBD and compares it with known antimalarial drugs. The results show that tanshinones have a strong binding affinity with the Delta RBD, while methylene blue exhibits slightly decreased affinity.
NATURAL PRODUCT RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Si-Yu Yuan, Hai-Bo Yu, Zhen Yang, Yi-Ping Qin, Ji-Hua Ren, Sheng-Tao Cheng, Fang Ren, Betty Yuen Kwan Law, Vincent Kam Wai Wong, Jerome P. L. Ng, Yu-Jiao Zhou, Xin He, Ming Tan, Zhen-Zhen Zhang, Juan Chen
Summary: This study identified pimobendan as a potential drug with strong antiviral activity against hepatitis B virus (HBV). Pimobendan inhibits HBV transcription, leading to reduced production of HBsAg. These findings provide a promising lead for the development of new anti-HBV agents.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ren Fang, Tan Ming, Jerome P. L. Ng, Wu An Guo, Yuan Si Yu, Zhang Hui, Ren Ji Hua, Cheng Sheng Tao, Zhang Juan, Lo Hang Hong, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Chen Juan
Summary: A compound called Ciliatoside A, extracted from the plant Peristrophe japonica, has been identified as a potential antiviral agent against hepatitis B. It functions by inducing autophagy to degrade viral proteins and inhibit HBV replication. This study provides important insights for the development of hepatitis B cure drugs.
ANTIVIRAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Giovanni Ribaudo, Xiaoyun Yun, Alberto Ongaro, Erika Oselladore, Jerome P. L. Ng, Richard K. Haynes, Betty Yuen Kwan Law, Maurizio Memo, Vincent Kam Wai Wong, Paolo Coghi, Alessandra Gianoncelli
Summary: By utilizing computational tools, this study identified two potential antimalarial drugs, amodiaquine and methylene blue, as possible PLpro inhibitors. These findings provide a starting point for the development of new PLpro inhibitors.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Review
Plant Sciences
Li Zhang, Yuan-Yuan Yong, Lan Deng, Jing Wang, Betty Yuen-Kwan Law, Meng-Ling Hu, Jian-Ming Wu, Lu Yu, Vincent Kam-Wai Wong, Chong-Lin Yu, Da-Lian Qin, Xiao-Gang Zhou, An-Guo Wu
Summary: Polygala genus and its major bioactive component, Polygala saponins, have shown therapeutic potential in various neurological diseases, exhibiting neuroprotective effects and modulating inflammation and oxidative stress. However, Polygala saponins can induce gastrointestinal toxicity, which can be ameliorated using specific processing methods.
Article
Plant Sciences
Chang-Long He, Yong Tang, Xue Chen, Tao Long, Yan-Ni He, Jing Wei, Jian-Ming Wu, Cai Lan, Lu Yu, Fei-Hong Huang, Cong-Wei Gu, Jian Liu, Chong-Lin Yu, Vincent Kam-Wai Wong, Betty Yuen-Kwan Law, Da-Lian Qin, An-Guo Wu, Xiao-Gang Zhou
Summary: In this study, natural autophagy enhancers were screened from traditional Chinese medicines (TCMs), and they showed potent neuroprotective potential in multiple neurodegenerative disease (ND) models.
Article
Clinical Neurology
Joseph H. C. Lai, Jiaxin Liu, Tian Yang, Jianpan Huang, Yang Liu, Zilin Chen, Youngjin Lee, Gilberto K. K. Leung, Kannie W. Y. Chan
Summary: In this study, researchers used CEST magnetic resonance imaging to monitor molecular changes in hematoma after intracerebral hemorrhage (ICH). The results showed that this technique could noninvasively monitor and guide treatments. Specifically, the researchers observed differences in contrasts between rNOE and amide proton transfer at different time points and locations, and these contrast changes were highly consistent with histological findings. Based on the results, CEST magnetic resonance imaging can be used to monitor molecular changes and related tissue characteristics during ICH and treatment.
Article
Chemistry, Physical
Yunjian Ma, Zongquan Li, Hao Zhang, Vincent Kam Wai Wong, Frank Hollmann, Yonghua Wang
Summary: This study proposes a parallel cascade using aryl alcohol oxidase (PeAAOx) from Pleurotus eryngii and unspecific peroxygenase (AaeUPO) from Agrocybe aegerita to convert aromatic primary alcohols into high-value aromatic aldehydes. Key factors such as enzyme dosage, pH, and temperature were investigated. The study evaluates the universality of PeAAOx coupled with AaeUPO cascade catalysis for the synthesis of aromatic aldehyde flavor compounds.
Article
Pharmacology & Pharmacy
Yuan-Qing Qu, Lin-Lin Song, Su-Wei Xu, Margaret Sum Yee Yu, Onat Kadioglu, Francesco Michelangeli, Betty Yuen Kwan Law, Thomas Efferth, Christopher Wai- Kei Lam, Vincent Kam Wai Wong
Summary: In this study, pomiferin, a natural product from Osage Orange, was found to activate autophagy and inhibit drug efflux to overcome innate and acquired drug resistance in cancer cells. It also exhibited tumor suppression and anti-metastatic effects in animal models. Pomiferin could serve as a novel effective agent for circumventing drug resistance in clinical applications.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Biotechnology & Applied Microbiology
Shijie Fu, Yujian Lan, Guoyou Wang, Dingsu Bao, Bo Qin, Qiu Zheng, Huan Liu, Vincent Kam Wai Wong
Summary: Injuries at the tendon-bone interface are common and complex, affecting patients' quality of life. Restoring stability and promoting healing of the tendon-bone interface is essential. This review discusses the effects of extracorporeal shock waves, low-intensity pulsed ultrasound, and mechanical stress on tendon-bone healing, focusing on their possible mechanisms of action. The aim is to provide potential therapeutic approaches for clinical treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
