The remote allosteric control of Orai channel gating

A novel STIM1-Orai1 gating interface essential for CRAC channel activation

(2019) Carmen Butorac et al.   CELL CALCIUM

Molecular understanding of calcium permeation through the open Orai channel

(2019) Xiaofen Liu et al.   PLOS BIOLOGY

Cross-linking of Orai1 channels by STIM proteins

(2018) Yandong Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating

(2018) Priscilla S.-W. Yeung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Communication between N terminus and loop2 tunes Orai activation

(2017) Marc Fahrner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription

(2017) Irene Frischauf et al.   Science Signaling

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate

(2017) Megumi Yamashita et al.   Nature Communications

Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription

(2017) Irene Frischauf et al.   Science Signaling

The STIM1-binding site nexus remotely controls Orai1 channel gating

(2016) Yandong Zhou et al.   Nature Communications

Diseases caused by mutations inORAI1andSTIM1

(2015) Rodrigo S. Lacruz et al.   Annals of the New York Academy of Sciences

Critical role for Orai1 C-terminal domain and TM4 in CRAC channel gating

(2015) Raz Palty et al.   CELL RESEARCH

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

STIM1 dimers undergo unimolecular coupling to activate Orai1 channels

(2015) Yandong Zhou et al.   Nature Communications

Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding

(2015) Leidamarie Tirado-Lee et al.   PLoS One

Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis

(2014) V. Nesin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel

(2014) Aparna Gudlur et al.   Nature Communications

The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1

(2013) Isabella Derler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orai Channel Pore Properties and Gating by STIM: Implications from the Orai Crystal Structure

(2013) B. S. Rothberg et al.   Science Signaling

STIM proteins: dynamic calcium signal transducers

(2012) Jonathan Soboloff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

(2012) X. Hou et al.   SCIENCE

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation

(2008) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY