Journal
NEUROSCIENCE RESEARCH
Volume 139, Issue -, Pages 21-25Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2018.07.008
Keywords
Axon; Wallerian degeneration; Apoptosis; E3 ubiquitin ligase; Proteasome; Autophagy; Kinase
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science
- Intramural Research Grant for Neurological and Psychiatric Disorders of NCNP
- Takeda Science Foundation
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ZNRF1 is an E3 ubiquitin ligase constitutively expressed in almost all neurons in the central and peripheral nervous systems during development and in adulthood. From this expression profile, the role of ZNRF1 is assumed to be common to many different types of neurons. We have analyzed the roles of ZNRF1-dependent degradation of target proteins in neurons. In mature neurons, ZNRF1 is activated in response to different types of stress that cause neuronal/axonal degeneration, and degrade AKT to activate GSK3B. Here we summarize the subcellular signaling events downstream of GSK3B activation, and their roles in the progression of neuronal/axonal degeneration. (C) 2018 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.
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