Linking Molecular Pathways and Large-Scale Computational Modeling to Assess Candidate Disease Mechanisms and Pharmacodynamics in Alzheimer's Disease

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

It’s all about tau

(2019) Cheril Tapia-Rojas et al.   PROGRESS IN NEUROBIOLOGY

Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight

(2019) Taro Bannai et al.   Scientific Reports

Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer’s Disease and Systemic Inflammation

(2019) Jian Zhou et al.   NEUROCHEMICAL RESEARCH

Aluminum in Neurological and Neurodegenerative Disease

(2019) Donald R. C. McLachlan et al.   MOLECULAR NEUROBIOLOGY

Microglia in Alzheimer's disease: A target for immunotherapy

(2019) Shoutang Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Non-Alzheimer’s contributions to dementia and cognitive resilience in The 90+ Study

(2018) John L. Robinson et al.   ACTA NEUROPATHOLOGICA

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Electromagnetic signatures of the preclinical and prodromal stages of Alzheimer’s disease

(2018) Akinori Nakamura et al.   BRAIN

Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated

(2018) John L Robinson et al.   BRAIN

Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease

(2018) Lawrence S. Honig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Amyloid β causes excitation/inhibition imbalance through dopamine receptor 1-dependent disruption of fast-spiking GABAergic input in anterior cingulate cortex

(2018) Si-Qiang Ren et al.   Scientific Reports

Dementia: assessment, management and support: summary of updated NICE guidance

(2018) Joshua Pink et al.   BMJ-British Medical Journal

Infection of Fungi and Bacteria in Brain Tissue From Elderly Persons and Patients With Alzheimer’s Disease

(2018) Ruth Alonso et al.   Frontiers in Aging Neuroscience

Phase-lags in large scale brain synchronization: Methodological considerations and in-silico analysis

(2018) Spase Petkoski et al.   PLoS Computational Biology

Dementia: assessment, management and support: summary of updated NICE guidance

(2018) Joshua Pink et al.   BMJ-British Medical Journal

Differentiation of Alzheimer's disease based on local and global parameters in personalized Virtual Brain models

(2018) J. Zimmermann et al.   NeuroImage-Clinical

Impact of the biological definition of Alzheimer’s disease using amyloid, tau and neurodegeneration (ATN): what about the role of vascular changes, inflammation, Lewy body pathology?

(2018) S. Gauthier et al.   Translational Neurodegeneration

Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mild-to-moderate Alzheimer’s disease (BLAZE)

(2018) Stephen Salloway et al.   Alzheimers Research & Therapy

Grasping at straws: the failure of solanezumab to modify mild Alzheimer’s disease

(2018) Sheila A. Doggrell   EXPERT OPINION ON BIOLOGICAL THERAPY

Are antibodies directed against amyloid-β (Aβ) oligomers the last call for the Aβ hypothesis of Alzheimer's disease?

(2018) Francesco Panza et al.   Immunotherapy

The Blood brain-barrier and its role in Alzheimer’s disease

(2018) Steffen E. Storck et al.   Neuroforum

Memantine for Alzheimer’s Disease: An Updated Systematic Review and Meta-analysis

(2017) Taro Kishi et al.   JOURNAL OF ALZHEIMERS DISEASE

Dynamic models of large-scale brain activity

(2017) Michael Breakspear   NATURE NEUROSCIENCE

The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread

(2017) V.K. Jirsa et al.   NEUROIMAGE

Functional connectivity dynamically evolves on multiple time-scales over a static structural connectome: Models and mechanisms

(2017) Joana Cabral et al.   NEUROIMAGE

Treatment effects between monotherapy of donepezil versus combination with memantine for Alzheimer disease: A meta-analysis

(2017) Ruey Chen et al.   PLoS One

The dynamics of resting fluctuations in the brain: metastability and its dynamical cortical core

(2017) Gustavo Deco et al.   Scientific Reports

Electroencephalographic markers in dementia

(2016) N. Malek et al.   ACTA NEUROLOGICA SCANDINAVICA

Default mode network connectivity is linked to cognitive functioning and CSF Aβ1–42 levels in Alzheimer’s disease

(2016) Ozlem Celebi et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

The economic burden of dementia in China, 1990–2030: implications for health policy

(2016) Junfang Xu et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders

(2016) Robert W. Mahley   JOURNAL OF MOLECULAR MEDICINE-JMM

A multi-modal parcellation of human cerebral cortex

(2016) Matthew F. Glasser et al.   NATURE

Cortical sources of resting state EEG rhythms are related to brain hypometabolism in subjects with Alzheimer's disease: an EEG-PET study

(2016) Claudio Babiloni et al.   NEUROBIOLOGY OF AGING

Transcranial direct current stimulation changes resting state functional connectivity: A large-scale brain network modeling study

(2016) Tim Kunze et al.   NEUROIMAGE

Denoising of diffusion MRI using random matrix theory

(2016) Jelle Veraart et al.   NEUROIMAGE

PET Imaging of Tau Deposition in the Aging Human Brain

(2016) Michael Schöll et al.   NEURON

PETPVC: a toolbox for performing partial volume correction techniques in positron emission tomography

(2016) Benjamin A Thomas et al.   PHYSICS IN MEDICINE AND BIOLOGY

Safety and tolerability of BAN2401 - a clinical study in Alzheimer’s disease with a protofibril selective Aβ antibody

(2016) Veronika Logovinsky et al.   Alzheimers Research & Therapy

Cerebrovascular disease in ageing and Alzheimer’s disease

(2015) Seth Love et al.   ACTA NEUROPATHOLOGICA

Clinicopathologic and11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer’s disease spectrum

(2015) Melissa E. Murray et al.   BRAIN

Diagnostic accuracy of 18F amyloid PET tracers for the diagnosis of Alzheimer’s disease: a systematic review and meta-analysis

(2015) Elizabeth Morris et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Prevalence of Amyloid PET Positivity in Dementia Syndromes

(2015) Rik Ossenkoppele et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Brain Amyloid-  Burden Is Associated with Disruption of Intrinsic Functional Connectivity within the Medial Temporal Lobe in Cognitively Normal Elderly

(2015) Z. Song et al.   JOURNAL OF NEUROSCIENCE

Amyloid-  Impairs Synaptic Inhibition via GABAA Receptor Endocytosis

(2015) D. Ulrich   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

SIFT2: Enabling dense quantitative assessment of brain white matter connectivity using streamlines tractography

(2015) Robert E. Smith et al.   NEUROIMAGE

Mathematical framework for large-scale brain network modeling in The Virtual Brain

(2015) Paula Sanz-Leon et al.   NEUROIMAGE

An automated pipeline for constructing personalized virtual brains from multimodal neuroimaging data

(2015) Michael Schirner et al.   NEUROIMAGE

The Rediscovery of Slowness: Exploring the Timing of Cognition

(2015) Morten L. Kringelbach et al.   TRENDS IN COGNITIVE SCIENCES

The Virtual Brain: Modeling Biological Correlates of Recovery after Chronic Stroke

(2015) Maria Inez Falcon et al.   Frontiers in Neurology

Intracellular Accumulation of Amyloid-  (A ) Protein Plays a Major Role in A -Induced Alterations of Glutamatergic Synaptic Transmission and Plasticity

(2014) C. Ripoli et al.   JOURNAL OF NEUROSCIENCE

Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50–89 years: a cross-sectional study

(2014) Clifford R Jack et al.   LANCET NEUROLOGY

Amyloid-Beta: A Crucial Factor in Alzheimer's Disease

(2014) Saeed Sadigh-Eteghad et al.   MEDICAL PRINCIPLES AND PRACTICE

MSM: A new flexible framework for Multimodal Surface Matching

(2014) Emma C. Robinson et al.   NEUROIMAGE

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Amyloidosis in Alzheimer’s Disease: The Toxicity of Amyloid Beta (Aβ), Mechanisms of Its Accumulation and Implications of Medicinal Plants for Therapy

(2013) Anchalee Prasansuklab et al.   Evidence-based Complementary and Alternative Medicine

Systematic approximations of neural fields through networks of neural masses in the virtual brain

(2013) A. Spiegler et al.   NEUROIMAGE

The minimal preprocessing pipelines for the Human Connectome Project

(2013) Matthew F. Glasser et al.   NEUROIMAGE

Determination of the appropriatebvalue and number of gradient directions for high-angular-resolution diffusion-weighted imaging

(2013) J.-Donald Tournier et al.   NMR IN BIOMEDICINE

From Oscillatory Transcranial Current Stimulation to Scalp EEG Changes: A Biophysical and Physiological Modeling Study

(2013) Isabelle Merlet et al.   PLoS One

Inhibitory Neuron and Hippocampal Circuit Dysfunction in an Aged Mouse Model of Alzheimer's Disease

(2013) Anupam Hazra et al.   PLoS One

The Virtual Brain: a simulator of primate brain network dynamics

(2013) Paula Sanz Leon et al.   Frontiers in Neuroinformatics

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

What is the Source of the EEG?

(2012) Timo Kirschstein et al.   CLINICAL EEG AND NEUROSCIENCE

Within-subject template estimation for unbiased longitudinal image analysis

(2012) Martin Reuter et al.   NEUROIMAGE

Anatomically-constrained tractography: Improved diffusion MRI streamlines tractography through effective use of anatomical information

(2012) Robert E. Smith et al.   NEUROIMAGE

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of functional GABAA receptors in the Alzheimer diseased brain

(2012) A. Limon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease

(2012) Christine Grienberger et al.   Nature Communications

Use of Florbetapir-PET for Imaging β-Amyloid Pathology

(2011) Christopher M. Clark   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

FSL

(2011) Mark Jenkinson et al.   NEUROIMAGE

Modeling Brain Resonance Phenomena Using a Neural Mass Model

(2011) Andreas Spiegler et al.   PLoS Computational Biology

Brainstorm: A User-Friendly Application for MEG/EEG Analysis

(2011) François Tadel et al.   Computational Intelligence and Neuroscience

EEG and MEG Data Analysis in SPM8

(2011) Vladimir Litvak et al.   Computational Intelligence and Neuroscience

Connecting Mean Field Models of Neural Activity to EEG and fMRI Data

(2010) Ingo Bojak et al.   BRAIN TOPOGRAPHY

The economic impact of dementia in Europe in 2008-cost estimates from the Eurocode project

(2010) A. Wimo et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Bifurcation analysis of neural mass models: Impact of extrinsic inputs and dendritic time constants

(2010) Andreas Spiegler et al.   NEUROIMAGE

Fundamental limits of spatial resolution in PET

(2010) William W. Moses   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

High Striatal Amyloid β-Peptide Deposition Across Different Autosomal Alzheimer Disease Mutation Types

(2009) Victor L. Villemagne et al.   ARCHIVES OF NEUROLOGY

Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease

(2009) Clifford R. Jack et al.   BRAIN

Neural field dynamics with local and global connectivity and time delay

(2009) V. K Jirsa   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Bayesian analysis of neuroimaging data in FSL

(2008) Mark W. Woolrich et al.   NEUROIMAGE

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE

The Dynamic Brain: From Spiking Neurons to Neural Masses and Cortical Fields

(2008) Gustavo Deco et al.   PLoS Computational Biology

A Low Dimensional Description of Globally Coupled Heterogeneous Neural Networks of Excitatory and Inhibitory Neurons

(2008) Roxana A. Stefanescu et al.   PLoS Computational Biology

Noise during Rest Enables the Exploration of the Brain's Dynamic Repertoire

(2008) Anandamohan Ghosh et al.   PLoS Computational Biology

Biophysical model for integrating neuronal activity, EEG, fMRI and metabolism

(2007) Roberto C. Sotero et al.   NEUROIMAGE