Article
Food Science & Technology
Claudia M. Guerra-Vazquez, Mariana Martinez-Avila, Daniel Guajardo-Flores, Marilena Antunes-Ricardo
Summary: Punicic acid, a bioactive compound found in pomegranate seed oil, has strong anti-oxidative and anti-inflammatory effects. It can reduce oxidative damage and inflammation, increase the expression of certain proteins, and enhance antioxidant activity. Punicic acid shows promise in the prevention and treatment of neurodegenerative diseases.
Review
Biochemistry & Molecular Biology
Yelizhati Ruzha, Junjun Ni, Zhenzhen Quan, Hui Li, Hong Qing
Summary: VTN is a multifunctional glycoprotein that plays various physiological roles and is involved in cell attachment, migration, neural differentiation, neurogenesis, and also has neuroprotective effects on the brain. It is associated with the blood-brain barrier and neurodegenerative diseases, although its exact function in these contexts is not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Abbie C. Johnson
Summary: With the increase in aging population and lack of effective treatments for dementia, the incidence of age-related dementia is on the rise. Vascular factors contributing to cognitive impairment and dementia are also increasing due to the prevalence of cerebrovascular diseases such as chronic hypertension, diabetes, and ischemic stroke. This review focuses on the role of the hippocampal vasculature in maintaining neurocognitive health, its contribution to vascular cognitive impairment and dementia, and its potential as a therapeutic target to slow cognitive decline.
Review
Cell Biology
Ming Zhao, Xue-Fan Jiang, Hui-Qin Zhang, Jia-Hui Sun, Hui Pei, Li-Na Ma, Yu Cao, Hao Li
Summary: Alzheimer's disease is an irreversible neurodegenerative disorder with no satisfying curative therapies currently available. Dysfunction of the blood-brain barrier contributes to the onset and progression of AD, yet the pathogenesis caused by BBB injury remains unclear. Glial cells play a crucial role in maintaining the integrity of BBB and neuronal function.
AGEING RESEARCH REVIEWS
(2021)
Review
Immunology
Rui Yang, Mingming Chen, Jiayin Zheng, Xin Li, Xiaojuan Zhang
Summary: This review summarizes the role of glycocalyx in BBB formation and highlights the therapeutic potential of heparin in maintaining BBB integrity. It provides a theoretical basis for the treatment of neurological diseases related to BBB breakdown.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Psychiatry
Jie Dai, Min-zhe Zhang, Qi-qiang He, Rui Chen
Summary: Schizophrenia is a serious mental disorder and a leading cause of disease burden worldwide. Exosomes, as natural nanocarriers, have the ability to cross the blood-brain barrier and play a crucial role in central nervous system communication. This article reviews the current research on exosomes and schizophrenia, discussing their roles as biomarkers and therapeutic targets, as well as the challenges faced in this field.
PSYCHIATRY RESEARCH
(2023)
Review
Neurosciences
Xiaoshu Chen, Xinru Pang, Abrey J. Yeo, Siwen Xie, Mengting Xiang, Bin Shi, Gongchang Yu, Chao Li
Summary: The blood-brain barrier is an important protective barrier of the central nervous system that prevents harmful substances from entering. Dysfunction of the blood-brain barrier is an early sign of nervous system diseases. Recent studies have focused on ferroptosis, a novel cell death mode caused by iron-mediated lipid peroxidation accumulation, and its potential role in blood-brain barrier dysfunction. Understanding the relationship between ferroptosis and blood-brain barrier dysfunction may lead to new treatment targets for brain diseases.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Suyeong Seo, Seung-Yeol Nah, Kangwon Lee, Nakwon Choi, Hong Nam Kim
Summary: The study introduced an engineered 3D human glioblastoma in vitro platform integrated with a tricultured BBB, allowing for mimicking the physiological environment of brain tumors. The platform showed potential for studying the physiology of the BBB and monitoring drug responses based on the interaction between brain tumor cells and the BBB.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Cell Biology
Ilenia Martinelli, Seyed Khosrow Tayebati, Daniele Tomassoni, Giulio Nittari, Proshanta Roy, Francesco Amenta
Summary: This article reviews the development and technical analysis of brain and retinal organoids, and discusses their potential in modeling neurological and retinal diseases, as well as their use as screening tools. Furthermore, potential future directions, such as dedicated biobanks, are proposed.
Article
Geriatrics & Gerontology
Qing-Qing Tao, Rong-Rong Lin, Yi-He Chen, Zhi-Ying Wu
Summary: Alzheimer's disease is the most common neurodegenerative disease characterized by the accumulation of Aβ and tau in the brain. The dysfunction of the blood brain barrier (BBB) is increasingly recognized as a causative factor of cognitive impairment, but its role in the pathogenesis of AD is still not fully understood. Additional research is needed to determine the underlying mechanisms between BBB dysfunction and AD, as well as explore new therapies for BBB regulation to treat AD in the future.
Review
Biochemistry & Molecular Biology
Roberta Lattanzi, Rossella Miele
Summary: Prokineticins are a new class of peptides that play a crucial role in neuroinflammatory processes, regulating neuronal-glial interactions and T cell function. PK2 and PKRs are upregulated during inflammation, influencing inflammatory responses and directing T cells towards a pro-inflammatory phenotype.
Review
Biochemistry & Molecular Biology
Ana Aragon-Gonzalez, Pamela J. Shaw, Laura Ferraiuolo
Summary: This review provides a detailed explanation of the importance of maintaining a healthy blood-brain barrier (BBB) for disease prevention and the main pathomechanisms affecting BBB function. Barrier disruption is a common feature in both neurodegenerative and neurodevelopmental diseases. Potential therapies based on the BBB properties, such as molecular Trojan horses, and innovative treatments like stem cell therapies are being reviewed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Sehwan Kim, Chanchal Sharma, Un Ju Jung, Sang Ryong Kim
Summary: The blood-brain barrier regulates the entry of harmful substances into the brain and its impairment leads to neuroinflammation and cognitive decline associated with Alzheimer's disease. Blood-borne proteins, such as prothrombin and fibrinogen, infiltrate the brain, activate microglia, and exacerbate neuroinflammatory responses. Identifying these proteins and understanding the mechanisms of microglial activation-mediated neuroinflammation can provide therapeutic strategies for AD prevention.
Review
Biochemistry & Molecular Biology
Lei Wang, Xu Zhang, Xiaoxing Xiong, Hua Zhu, Ran Chen, Shudi Zhang, Gang Chen, Zhihong Jian
Summary: Cerebral ischemic stroke is a disease with limited clinical treatments, and the recovery of cerebral blood circulation can cause cerebral ischemia-reperfusion injury. Nrf2, a critical antioxidant transcription factor, plays a cytoprotective role by modulating multiple signaling pathways, including anti-oxidative stress, anti-inflammation, and maintaining mitochondrial homeostasis, making it a potential strategy for preventing and treating cerebral ischemic injury.
Review
Immunology
Orianne Constant, Ghizlane Maarifi, Fabien P. Blanchet, Philippe van de Perre, Yannick Simonin, Sara Salinas
Summary: This review highlights the important contribution of dendritic cells in the development and consequences of viral brain infections.
FRONTIERS IN IMMUNOLOGY
(2022)
