Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation

Spatiotemporal Multi-omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease

(2018) Florian Schlotter et al.   CIRCULATION

Sex-Specific Outcomes After Transcatheter Aortic Valve Replacement: FDA Patient-Level Meta-Analysis of Premarket Clinical Trials

(2018) Robbert Zusterzeel et al.   JOURNAL OF WOMENS HEALTH

Engineering precision biomaterials for personalized medicine

(2018) Brian A. Aguado et al.   Science Translational Medicine

Biomaterial Scaffolds as Pre-metastatic Niche Mimics Systemically Alter the Primary Tumor and Tumor Microenvironment

(2018) Brian A. Aguado et al.   Advanced Healthcare Materials

A Reversible and Repeatable Thiol–Ene Bioconjugation for Dynamic Patterning of Signaling Proteins in Hydrogels

(2018) Joseph C. Grim et al.   ACS Central Science

Association of Renin-Angiotensin Inhibitor Treatment With Mortality and Heart Failure Readmission in Patients With Transcatheter Aortic Valve Replacement

(2018) Taku Inohara et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Degenerative changes and immune response after transcatheter aortic valve implantation. Comparison with surgical aortic valve replacement

(2017) Jakub Sulženko et al.   Journal of Cardiology

The shift of macrophages toward M1 phenotype promotes aortic valvular calcification

(2017) Geng Li et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Pathophysiology of Aortic Valve Stenosis: Is It Both Fibrocalcific and Sex Specific?

(2017) Yoginee Sritharen et al.   PHYSIOLOGY

Reversibility of Cardiac Function Predicts Outcome After Transcatheter Aortic Valve Replacement in Patients With Severe Aortic Stenosis

(2017) Kimi Sato et al.   Journal of the American Heart Association

Active tissue stiffness modulation controls valve interstitial cell phenotype and osteogenic potential in 3D culture

(2016) Bin Duan et al.   Acta Biomaterialia

Sex-related differences in left ventricular remodeling in severe aortic stenosis and reverse remodeling after aortic valve replacement: A cardiovascular magnetic resonance study

(2016) Laura E. Dobson et al.   AMERICAN HEART JOURNAL

Inflammation Drives Retraction, Stiffening, and Nodule Formation via Cytoskeletal Machinery in a Three-Dimensional Culture Model of Aortic Stenosis

(2016) Jina Lim et al.   AMERICAN JOURNAL OF PATHOLOGY

Sex-Specific Differences at Presentation and Outcomes Among Patients Undergoing Transcatheter Aortic Valve Replacement

(2016) Susheel Kodali et al.   ANNALS OF INTERNAL MEDICINE

Aptamer-Based Proteomic Profiling Reveals Novel Candidate Biomarkers and Pathways in Cardiovascular DiseaseClinical Perspective

(2016) Debby Ngo et al.   CIRCULATION

Medical Treatment of Aortic Stenosis

(2016) Guillaume Marquis-Gravel et al.   CIRCULATION

Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation

(2016) Jesper Hjortnaes et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

TAVR Prognosis, Aging, and the Second TAVR Tsunami

(2016) John D. Carroll   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Transcatheter Aortic Valve Replacement 2016

(2016) Torsten P. Vahl et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Thromboinflammatory response and predictors of outcomes in patients undergoing transcatheter aortic valve replacement

(2016) Travis R. Sexton et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown

(2016) Mihaela Pertea et al.   Nature Protocols

Seguimiento a largo plazo tras implante percutáneo de válvula aórtica por estenosis aórtica grave

(2016) Pablo Salinas et al.   REVISTA ESPANOLA DE CARDIOLOGIA

The IL-1 cytokine family and its role in inflammation and fibrosis in the lung

(2016) L. A. Borthwick   Seminars in Immunopathology

Assessment of Prosthetic Valve Function After TAVR

(2016) Sorin V. Pislaru et al.   JACC-Cardiovascular Imaging

Integrating valve-inspired design features into poly(ethylene glycol) hydrogel scaffolds for heart valve tissue engineering

(2015) Xing Zhang et al.   Acta Biomaterialia

Dynamic stiffening of poly(ethylene glycol)-based hydrogels to direct valvular interstitial cell phenotype in a three-dimensional environment

(2015) Kelly M. Mabry et al.   BIOMATERIALS

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

(2015) Marie Genin et al.   BMC CANCER

Drug Therapy for Heart Valve Diseases: Table.

(2015) Jeffrey S. Borer et al.   CIRCULATION

Sex-related differences in calcific aortic stenosis: correlating clinical and echocardiographic characteristics and computed tomography aortic valve calcium score to excised aortic valve weight

(2015) Jeremy J. Thaden et al.   EUROPEAN HEART JOURNAL

2-Year Outcomes in Patients Undergoing Surgical or Self-Expanding Transcatheter Aortic Valve Replacement

(2015) Michael J. Reardon et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Ascorbic acid promotes extracellular matrix deposition while preserving valve interstitial cell quiescence within 3D hydrogel scaffolds

(2015) Yan Wu et al.   Journal of Tissue Engineering and Regenerative Medicine

Sex Differences in Aortic Stenosis and Outcome Following Surgical and Transcatheter Aortic Valve Replacement

(2015) Laura E. Dobson et al.   JOURNAL OF WOMENS HEALTH

ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap

(2015) Tauno Metsalu et al.   NUCLEIC ACIDS RESEARCH

Secretome identification of immune cell factors mediating metastatic cell homing

(2015) Brian A. Aguado et al.   Scientific Reports

Technical Approach Determines Inflammatory Response after Surgical and Transcatheter Aortic Valve Replacement

(2015) Gabor Erdoes et al.   PLoS One

IL-1β suppresses TGF-β-mediated myofibroblast differentiation in cardiac fibroblasts

(2014) Hasse Brønnum et al.   GROWTH FACTORS

Sex-Related Differences in Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Patients With Severe Aortic Stenosis

(2014) Mathew Williams et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiac valve cells and their microenvironment—insights from in vitro studies

(2014) Huan Wang et al.   Nature Reviews Cardiology

Aortic-Valve Stenosis — From Patients at Risk to Severe Valve Obstruction

(2014) Catherine M. Otto et al.   NEW ENGLAND JOURNAL OF MEDICINE

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Fibrocalcific Aortic Valve Disease

(2013) Robert M. Weiss et al.   CIRCULATION RESEARCH

Transcatheter Aortic Valve Implantation Reduces Sympathetic Activity and Normalizes Arterial Spontaneous Baroreflex in Patients With Aortic Stenosis

(2013) Nicolas Dumonteil et al.   JACC-Cardiovascular Interventions

Aortic Stenosis in the Elderly

(2013) Ruben L.J. Osnabrugge et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway

(2013) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small peptide functionalized thiol–ene hydrogels as culture substrates for understanding valvular interstitial cell activation and de novo tissue deposition

(2012) Sarah T. Gould et al.   Acta Biomaterialia

Transcatheter aortic valve implantation 10-year anniversary: review of current evidence and clinical implications

(2012) P. Genereux et al.   EUROPEAN HEART JOURNAL

Myocardial tissue elastic properties determined by atomic force microscopy after stromal cell–derived factor 1α angiogenic therapy for acute myocardial infarction in a murine model

(2012) William Hiesinger et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Sex-Related Differences in Gene Expression by Porcine Aortic Valvular Interstitial Cells

(2012) Chloe M. McCoy et al.   PLoS One

Redirecting Valvular Myofibroblasts into Dormant Fibroblasts through Light-mediated Reduction in Substrate Modulus

(2012) Huan Wang et al.   PLoS One

Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-β1 pathways in cardiac fibroblasts

(2011) Li Li et al.   CARDIOVASCULAR RESEARCH

Upregulation of the 5-Lipoxygenase Pathway in Human Aortic Valves Correlates With Severity of Stenosis and Leads to Leukotriene-Induced Effects on Valvular Myofibroblasts

(2011) Edit Nagy et al.   CIRCULATION

Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling

(2011) Tetyana G. Voloshenyuk et al.   CYTOKINE

Assessment of left ventricular function in aortic stenosis

(2011) Alper Ozkan et al.   Nature Reviews Cardiology

Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients

(2011) Craig R. Smith et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

(2011) Larry Gold et al.   PLoS One

Deficiency of Interleukin-1 Receptor Antagonist Induces Aortic Valve Disease in BALB/c Mice

(2010) Kikuo Isoda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tumor Necrosis Factor-  Accelerates the Calcification of Human Aortic Valve Interstitial Cells Obtained from Patients with Calcific Aortic Valve Stenosis via the BMP2-Dlx5 Pathway

(2010) Z. Yu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery

(2010) Martin B. Leon et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Versatile Synthetic Extracellular Matrix Mimic via Thiol-Norbornene Photopolymerization

(2009) Benjamin D. Fairbanks et al.   ADVANCED MATERIALS

In situ elasticity modulation with dynamic substrates to direct cell phenotype

(2009) April M. Kloxin et al.   BIOMATERIALS

The controversial role of tumor necrosis factor α in fibrotic diseases

(2008) Jörg H. W. Distler et al.   ARTHRITIS AND RHEUMATISM