Instability in a coiled‐coil signaling helix is conserved for signal transduction in soluble guanylyl cyclase

The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein

(2019) Chao Qi et al.   SCIENCE

Targeting transcriptional control of soluble guanylyl cyclase via NOTCH for prevention of cardiovascular disease

(2018) C. Rippe et al.   Acta Physiologica

Structure/function of the soluble guanylyl cyclase catalytic domain

(2018) Kenneth C. Childers et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential

(2018) E.S. Buys et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Genetic alterations in the NO-cGMP pathway and cardiovascular risk

(2018) Jana Wobst et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Asymmetric activation mechanism of a homodimeric red light-regulated photoreceptor

(2018) Geoffrey Gourinchas et al.   eLife

Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase

(2017) Jessica A. Wales et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation

(2017) Irene Vercellino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of cGMP-Dependent Protein Kinase (PKG) Iα Leucine Zippers Reveal an Interchain Disulfide Bond Important for Dimer Stability

(2015) Liying Qin et al.   BIOCHEMISTRY

Coiled-coil length: Size does matter

(2015) Jaroslaw Surkont et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Interfacial Residues Promote an Optimal Alignment of the Catalytic Center in Human Soluble Guanylate Cyclase: Heterodimerization Is Required but Not Sufficient for Activity

(2014) Franziska Seeger et al.   BIOCHEMISTRY

Single-particle EM reveals the higher-order domain architecture of soluble guanylate cyclase

(2014) M. G. Campbell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coiled-Coil Helix Rotation Selects Repressing or Activating State of Transcriptional Regulator DhaR

(2014) Rong Shi et al.   STRUCTURE

Nitric Oxide-Induced Conformational Changes in Soluble Guanylate Cyclase

(2014) Eric S. Underbakke et al.   STRUCTURE

The Chemistry and Biology of Soluble Guanylate Cyclase Stimulators and Activators

(2013) Markus Follmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Model of a Soluble Guanylyl Cyclase Fragment Determined by Small-Angle X-ray Scattering and Chemical Cross-Linking

(2013) Bradley G. Fritz et al.   BIOCHEMISTRY

YC-1 Binding to the β Subunit of Soluble Guanylyl Cyclase Overcomes Allosteric Inhibition by the α Subunit

(2013) Rahul Purohit et al.   BIOCHEMISTRY

Crystal Structures of the Catalytic Domain of Human Soluble Guanylate Cyclase

(2013) Charles K. Allerston et al.   PLoS One

Crystal structure of the Alpha subunit PAS domain from soluble guanylyl cyclase

(2013) Rahul Purohit et al.   PROTEIN SCIENCE

Full-Length Structure of a Sensor Histidine Kinase Pinpoints Coaxial Coiled Coils as Signal Transducers and Modulators

(2013) Ralph P. Diensthuber et al.   STRUCTURE

Structure and Regulation of Soluble Guanylate Cyclase

(2012) Emily R. Derbyshire et al.   Annual Review of Biochemistry

The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase

(2012) Jonathan A Winger et al.   BMC STRUCTURAL BIOLOGY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Oxidation and Loss of Heme in Soluble Guanylyl Cyclase fromManduca sexta

(2011) Bradley G. Fritz et al.   BIOCHEMISTRY

An Undecided Coiled Coil

(2011) Rebecca Croasdale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Fluorescent Fusion Proteins of Soluble Guanylyl Cyclase Indicate Proximity of the Heme Nitric Oxide Domain and Catalytic Domain

(2010) Tobias Haase et al.   PLoS One

Crystal structure of the signaling helix coiled-coil domain of the β1 subunit of the soluble guanylyl cyclase

(2010) Xiaolei Ma et al.   BMC STRUCTURAL BIOLOGY

The role of position a in determining the stability and oligomerization state of α-helical coiled coils: 20 amino acid stability coefficients in the hydrophobic core of proteins

(2009) Kurt Wagschal et al.   PROTEIN SCIENCE

Allostery in Recombinant Soluble Guanylyl Cyclase fromManduca sexta

(2008) Xiaohui Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of Dimeric GIT1 and Trimeric β-PIX and Implications for GIT–PIX Complex Assembly

(2008) Oliver Schlenker et al.   JOURNAL OF MOLECULAR BIOLOGY

Binding of YC-1 or BAY 41-2272 to Soluble Guanylyl Cyclase Induces a Geminate Phase in CO Photolysis

(2008) Xiaohui Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY