Targeting transcriptional control of soluble guanylyl cyclase via NOTCH for prevention of cardiovascular disease

Characterizing isomiR variants within the microRNA-34/449 family

(2017) Olivier Mercey et al.   FEBS LETTERS

Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL

(2017) Arturo I. Machuca-Parra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Irreversible Activation and Stabilization of Soluble Guanylate Cyclase by the Protoporphyrin IX Mimetic Cinaciguat

(2017) Alexander Kollau et al.   MOLECULAR PHARMACOLOGY

Genome-Wide Association Study Implicates Atrial Natriuretic Peptide Rather Than B-Type Natriuretic Peptide in the Regulation of Blood Pressure in the General PopulationCLINICAL PERSPECTIVE

(2017) Perttu P. Salo et al.   Circulation-Cardiovascular Genetics

Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling

(2017) Connor A. Emdin et al.   CIRCULATION

Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathway

(2017) Catarina Rippe et al.   Scientific Reports

Adenine-induced chronic renal failure in rats decreases aortic relaxation rate and alters expression of proteins involved in vascular smooth muscle calcium handling

(2016) L. Nguy et al.   Acta Physiologica

miRNA-34a promotes proliferation of human pulmonary artery smooth muscle cells by targeting PDGFRA

(2016) Peng Wang et al.   CELL PROLIFERATION

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Thirty Years of Saying NO

(2016) Paul M. Vanhoutte et al.   CIRCULATION RESEARCH

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

(2016) Thomas J Hoffmann et al.   NATURE GENETICS

MicroRNAs in cardiovascular ageing

(2015) Timon Seeger et al.   JOURNAL OF PHYSIOLOGY-LONDON

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Arterial Hypertension Is Characterized by Imbalance of Pro-Angiogenic versus Anti-Angiogenic Factors

(2015) Natalia Marek-Trzonkowska et al.   PLoS One

Myocardin Family Members Drive Formation of Caveolae

(2015) Katarzyna K. Krawczyk et al.   PLoS One

Loss of α1β1 Soluble Guanylate Cyclase, the Major Nitric Oxide Receptor, Leads to Moyamoya and Achalasia

(2014) Dominique Hervé et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Archetypal Arg169Cys Mutation in NOTCH3 Does Not Drive the Pathogenesis in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leucoencephalopathy via a Loss-of-Function Mechanism

(2014) Emmanuel Cognat et al.   STROKE

Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis

(2013) C.-Y. Tsou et al.   Acta Physiologica

Rats with adenine-induced chronic renal failure develop low-renin, salt-sensitive hypertension and increased aortic stiffness

(2013) Lisa Nguy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Notch activation augments nitric oxide/soluble guanylyl cyclase signaling in immortalized ovarian surface epithelial cells and ovarian cancer cells

(2013) Ahmed El-Sehemy et al.   CELLULAR SIGNALLING

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Riociguat for the Treatment of Pulmonary Arterial Hypertension

(2013) Hossein-Ardeschir Ghofrani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Soluble guanylyl cyclase is a target of angiotensin II-induced nitrosative stress in a hypertensive rat model

(2012) Pierre-Antoine Crassous et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Structure and Regulation of Soluble Guanylate Cyclase

(2012) Emily R. Derbyshire et al.   Annual Review of Biochemistry

Transcriptome Analysis for Notch3 Target Genes Identifies Grip2 as a Novel Regulator of Myogenic Response in the Cerebrovasculature

(2012) Charles Fouillade et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

F3/Contactin acts as a modulator of neurogenesis during cerebral cortex development

(2012) Antonella Bizzoca et al.   DEVELOPMENTAL BIOLOGY

miR-221 Is Required for Endothelial Tip Cell Behaviors during Vascular Development

(2012) Stefania Nicoli et al.   DEVELOPMENTAL CELL

miRNA-34c regulates Notch signaling during bone development

(2012) Yangjin Bae et al.   HUMAN MOLECULAR GENETICS

NOTCH1 Nuclear Interactome Reveals Key Regulators of Its Transcriptional Activity and Oncogenic Function

(2012) Ahmad Yatim et al.   MOLECULAR CELL

MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles

(2012) Eva van Rooij et al.   NATURE REVIEWS DRUG DISCOVERY

Patterning the Artery Wall by Lateral Induction of Notch Signaling

(2011) Virginia J. Hoglund et al.   CIRCULATION

Notch Activation of Jagged1 Contributes to the Assembly of the Arterial Wall

(2011) Lauren J. Manderfield et al.   CIRCULATION

Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo

(2011) T. Oyama et al.   DEVELOPMENT

Notch Initiates the Endothelial-to-Mesenchymal Transition in the Atrioventricular Canal through Autocrine Activation of Soluble Guanylyl Cyclase

(2011) Alex C.Y. Chang et al.   DEVELOPMENTAL CELL

The functional genomics of guanylyl cyclase/natriuretic peptide receptor-A: Perspectives and paradigms

(2011) Kailash N. Pandey   FEBS Journal

The miR-143/145 Cluster Is a Novel Transcriptional Target of Jagged-1/Notch Signaling in Vascular Smooth Muscle Cells

(2011) Joshua M. Boucher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired vasoreactivity in mildly disabled CADASIL patients

(2011) Jonica Campolo et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

(2011) Georg B. Ehret et al.   NATURE

Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway

(2011) Brice Marcet et al.   NATURE CELL BIOLOGY

Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease

(2011) J. F. Arboleda-Velasquez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

The miR-34 family in cancer and apoptosis

(2009) H Hermeking   CELL DEATH AND DIFFERENTIATION

MicroRNA-206 Targetsnotch3, Activates Apoptosis, and Inhibits Tumor Cell Migration and Focus Formation

(2009) Guisheng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CADASIL

(2009) Hugues Chabriat et al.   LANCET NEUROLOGY

Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Notch3 signaling promotes the development of pulmonary arterial hypertension

(2009) Xiaodong Li et al.   NATURE MEDICINE

Moyamoya Disease and Moyamoya Syndrome

(2009) R. Michael Scott et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

(2009) Lars Wallentin et al.   NEW ENGLAND JOURNAL OF MEDICINE

MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells

(2009) Qing Ji et al.   PLoS One

Notch Signaling Specifies Megakaryocyte Development from Hematopoietic Stem Cells

(2008) Thomas Mercher et al.   Cell Stem Cell

Cyclic Guanosine Monophosphate-dependent Protein Kinase I Promotes Adhesion of Primary Vascular Smooth Muscle Cells

(2008) Pascal Weinmeister et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS

Linking Notch signaling to ischemic stroke

(2008) J. F. Arboleda-Velasquez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development

(2008) F. A. High et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA