Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase

Structural and Functional Evidence Indicates Selective Oxygen Signaling in Caldanaerobacter subterraneus H-NOX

(2016) Charles W. Hespen et al.   ACS Chemical Biology

Sparse multidimensional iterative lineshape-enhanced (SMILE) reconstruction of both non-uniformly sampled and conventional NMR data

(2016) Jinfa Ying et al.   JOURNAL OF BIOMOLECULAR NMR

Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans

(2016) Takashi Nakai et al.   ACS Medicinal Chemistry Letters

Organic Nitrate Therapy, Nitrate Tolerance, and Nitrate-Induced Endothelial Dysfunction: Emphasis on Redox Biology and Oxidative Stress

(2015) Andreas Daiber et al.   ANTIOXIDANTS & REDOX SIGNALING

Photoaffinity labeling in target- and binding-site identification

(2015) Ewan Smith et al.   Future Medicinal Chemistry

A Structural Basis for the Regulation of an H-NOX-Associated Cyclic-di-GMP Synthase/Phosphodiesterase Enzyme by Nitric Oxide-Bound H-NOX

(2014) Tanaya Lahiri et al.   BIOCHEMISTRY

NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy

(2014) Woonghee Lee et al.   BIOINFORMATICS

Surface plasmon resonance using the catalytic domain of soluble guanylate cyclase allows the detection of enzyme activators

(2014) Filipa Mota et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A diazirine-based photoaffinity probe for facile and efficient aptamer–protein covalent conjugation

(2014) Huimin Zhang et al.   CHEMICAL COMMUNICATIONS

Structural insights into the role of iron–histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins

(2014) Mark A. Herzik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Chemistry and Biology of Soluble Guanylate Cyclase Stimulators and Activators

(2013) Markus Follmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Model of a Soluble Guanylyl Cyclase Fragment Determined by Small-Angle X-ray Scattering and Chemical Cross-Linking

(2013) Bradley G. Fritz et al.   BIOCHEMISTRY

YC-1 Binding to the β Subunit of Soluble Guanylyl Cyclase Overcomes Allosteric Inhibition by the α Subunit

(2013) Rahul Purohit et al.   BIOCHEMISTRY

Using chemical shift perturbation to characterise ligand binding

(2013) Mike P. Williamson   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Nitric oxide-sensing H-NOX proteins govern bacterial communal behavior

(2013) Lars Plate et al.   TRENDS IN BIOCHEMICAL SCIENCES

Picosecond to Second Dynamics Reveals a Structural Transition in Clostridium botulinum NO-Sensor Triggered by the Activator BAY-41-2272

(2012) Byung-Kuk Yoo et al.   ACS Chemical Biology

Structure and Regulation of Soluble Guanylate Cyclase

(2012) Emily R. Derbyshire et al.   Annual Review of Biochemistry

Quaternary Structure Controls Ligand Dynamics in Soluble Guanylate Cyclase

(2012) Byung-Kuk Yoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and Discovery of 6-[(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a Selective Brain Penetrant PDE9A Inhibitor for the Treatment of Cognitive Disorders

(2012) Patrick R. Verhoest et al.   JOURNAL OF MEDICINAL CHEMISTRY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Accelerated NMR Spectroscopy by Using Compressed Sensing

(2011) Krzysztof Kazimierczuk et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Thrombospondin-1 and Angiotensin II Inhibit Soluble Guanylyl Cyclase through an Increase in Intracellular Calcium Concentration

(2011) Saumya Ramanathan et al.   BIOCHEMISTRY

Diazirine based photoaffinity labeling

(2011) Luba Dubinsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain

(2011) M. B. Winter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of non-uniformly sampled spectra with multi-dimensional decomposition

(2011) Vladislav Yu. Orekhov et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PINE-SPARKY: graphical interface for evaluating automated probabilistic peak assignments in protein NMR spectroscopy

(2009) W. Lee et al.   BIOINFORMATICS

Probabilistic Interaction Network of Evidence Algorithm and its Application to Complete Labeling of Peak Lists from Protein NMR Spectroscopy

(2009) Arash Bahrami et al.   PLoS Computational Biology

Allostery in Recombinant Soluble Guanylyl Cyclase fromManduca sexta

(2008) Xiaohui Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular System: Role of Nitric Oxide in Cardiovascular Diseases

(2008) Ka Bian et al.   Journal of Clinical Hypertension

Binding of YC-1 or BAY 41-2272 to Soluble Guanylyl Cyclase Induces a Geminate Phase in CO Photolysis

(2008) Xiaohui Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY