Review
Veterinary Sciences
Kelly Hall, Kenneth Drobatz
Summary: Resuscitation of acutely hemorrhaging small animal patients, such as dogs and cats, should prioritize hemorrhage control and judicious crystalloid administration followed by early consideration for blood component therapy to minimize blood loss, ameliorate coagulopathy, restore oxygen delivery, and correct changes in the glycocalyx.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Cell Biology
Paul Vulliamy, Lucy Z. Kornblith, Matthew E. Kutcher, Mitchell J. Cohen, Karim Brohi, Matthew D. Neal
Summary: Platelets play a crucial role in the initial response to tissue injury, with altered responsiveness observed in both acutely injured patients and survivors. Aside from their role in coagulation, platelets contribute to the sterile inflammatory response to injury and can impact multiple-organ dysfunction syndromes.
Article
Critical Care Medicine
Jason B. Brill, Megan Brenner, Juan Duchesne, Derek Roberts, Paula Ferrada, Tal Horer, David Kauvar, Mansoor Khan, Andrew Kirkpatrick, Carlos Ordonez, Bruno Perreira, Artai Priouzram, Bryan A. Cotton
Summary: Trauma-induced coagulopathy is associated with high mortality, and viscoelastic testing like TEG and ROTEM can predict massive transfusion and coagulopathy earlier than conventional testing, guiding resuscitation efforts after trauma.
Article
Critical Care Medicine
Taleen A. MacArthur, Grant M. Spears, Rosemary A. Kozar, Jing-fei Dong, Matthew Auton, Donald H. Jenkins, Kent R. Bailey, Aneel A. Ashrani, Mike J. Ferrara, Joseph M. Immermann, Timothy M. Halling, Myung S. Park
Summary: This study found that trauma patients with decreased arrival systolic blood pressure, increased INR, and decreased time to peak are at higher risk of requiring a high rate of packed red blood cell transfusions. Patients with accelerated thrombin generation have an increased risk of requiring transfusions.
Article
Critical Care Medicine
Christopher J. Dudek, Ian Little, Kyle Wiser, Joseph Ibrahim, Jose Ramirez, Linda Papa
Summary: This study retrospectively reviewed charts of trauma patients under 30 years old with active bleeding and found that TEG testing was associated with patients receiving TXA, MTP, and larger amounts of blood products, as well as significant correlations with PT and PIT levels. Patients who underwent TEG testing were more likely to undergo surgery within the first 24 hours of hospital arrival.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Anesthesiology
Pieter H. Sloos, M. Adrie W. Maas, Joost C. M. Meijers, Rienk Nieuwland, Joris J. T. H. Roelofs, Nicole P. Juffermans, Derek J. B. Kleinveld
Summary: Inhibition of HMGB-1 improves trauma-induced coagulopathy by enhancing clot formation and strength, preserving platelet count, and reducing bleeding time in a mouse model.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Review
Medicine, General & Internal
Geoffrey P. Dobson, Jodie L. Morris, Hayley L. Letson
Summary: This review provides an update on the effect of ALM therapy on increasing survival and blunting secondary injury after trauma and infection. ALM therapy resuscitates the body at permissive hypotensive blood pressures and confers neuroprotection. It resets the body's baroreflex and improves cardiovascular function, reduces inflammation, corrects coagulopathy, and reduces energy demand. ALM therapy has potential applications in stroke, muscle trauma, REBOA, burn polytrauma, damage control surgery, and orthopedic surgery.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Stefano Sartini, Marzia Spadaro, Ombretta Cutuli, Luca Castellani, Marina Sartini, Maria Luisa Cristina, Paolo Canepa, Chiara Tognoni, Agnese Lo, Lorenzo Canata, Martina Rosso, Eleonora Arboscello
Summary: This study aimed to investigate the impact of antithrombotic therapy on adverse outcomes in major trauma patients. The results showed that patients on anticoagulant treatment had higher mortality rates compared to those without antithrombotic treatment and those on antiplatelet treatment, but they also had fewer active treatments.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Andrew M. Fleming, Kinjal S. Shah, Saskya E. Byerly, Louis J. Magnotti, Peter E. Fischer, Catherine P. Seger, Andrew J. Kerwin, Martin A. Croce, Isaac W. Howley
Summary: This study aimed to evaluate the effects of early cryoprecipitate administration on inpatient mortality in the setting of massive transfusion for exsanguinating trauma and to use propensity score analysis to minimize selection bias. The results showed that early administration of cryoprecipitate was not associated with a difference in inpatient mortality.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Surgery
Giles L. Devaney, Seth M. Tarrant, Natasha Weaver, Kate L. King, Zsolt J. Balogh
Summary: Based on a 10-year data analysis, it was found that there was no mortality related to hemorrhage in patients with pelvic fractures, and transfusion and fluid requirements were also decreased for patients with traumatic shock.
WORLD JOURNAL OF SURGERY
(2023)
Article
Hematology
Ian S. LaCroix, Mitchell Cohen, Ernest E. Moore, Monika Dzieciatkowska, Christopher C. Silliman, Kirk C. Hansen, Angelo D'Alessandro
Summary: This study characterized the multi-omics features of platelet transfusion efficacy in a clinically relevant cohort of trauma patients using metabolomics and proteomics approaches. The results showed higher levels of tranexamic acid, inflammatory proteins, carnitines, and polyamines in patients requiring platelet transfusion. The study also identified increased platelet activation in the most severely injured patients. This study provides the first multi-omics characterization of platelet transfusion efficacy.
Review
Critical Care Medicine
Ioannis Hannadjas, Arthur James, Ross Davenport, Charlotte Lindsay, Karim Brohi, Elaine Cole
Summary: Among studies on TIC, PCCs did not significantly lower mortality and did not increase the risk of VTE. However, the potential thrombotic risk should be addressed in future studies. Several ongoing RCTs are exploring the efficacy and safety of PCC.
Review
Family Studies
Avrey Thau, Brooke Saffren, Helena Zakrzewski, James D. Anderst, Shannon L. Carpenter, Alex Levin
Summary: A systematic review was conducted to investigate the association of coagulopathies with retinal hemorrhages (RH) similar to those of abusive head trauma (AHT). There were cases of children with RH and concomitant coagulopathy in the AHT age range, but these cases did not exhibit classic characteristics of abuse-related RH. Coagulopathy alone has not been identified as a cause of RH consistent with AHT.
CHILD ABUSE & NEGLECT
(2021)
Article
Hematology
Jonathan P. Meizoso, Christopher D. Barrett, Ernest E. Moore, Hunter B. Moore
Summary: Uncontrolled bleeding is a leading cause of preventable death following injury. Viscoelastic hemostatic assays (VHA) have emerged as a superior method to guide goal-directed transfusion, particularly in the operating room and intensive care unit.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Anesthesiology
Florian Roquet, Anne Godier, Delphine Garrigue-Huet, Jean-Luc Hanouz, Fanny Vardon-Bounes, Vincent Legros, Romain Pirracchio, Sylvain Ausset, Jacques Duranteau, Bernard Vigue, Sophie Rym Hamada
Summary: This study examines coagulation factor administration strategies in French trauma centers, reporting the prevalence and timing of administration, quantity dispensed, and transfusion ratios. The main strategy for major bleeding combines the administration of fresh frozen plasma (FFP) and fibrinogen concentrate (FC), but compliance with the recommendations is low.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2023)
Article
Hematology
Melissa Chan, Melissa A. Hayman, Suthesh Sivapalaratnam, Marilena Crescente, Harriet E. Allan, Matthew L. Edin, Darryl C. Zeldin, Ginger L. Milne, Jonathan Stephens, Daniel Greene, Moghees Hanif, Valerie B. O'Donnell, Liang Dong, Michael G. Malkowski, Claire Lentaigne, Katherine Wedderburn, Matthew Stubbs, Kate Downes, Willem H. Ouwehand, Ernest Turro, Daniel P. Hart, Kathleen Freson, Michael A. Laffan, Timothy D. Warner
Summary: This study identified a rare PTGS1 variant associated with a bleeding phenotype and alterations in platelet reactivity and eicosanoid production in a large consanguineous family. The specific loss of platelet COX-1 activity was demonstrated for the first time in humans, providing important insights into platelet function and eicosanoid metabolism. Despite the absence of thromboxane A(2) formation by platelets, urinary thromboxane A(2) metabolites were in the normal range, suggesting the need for caution when using them as markers of in vivo platelet function.
Article
Pharmacology & Pharmacy
Chih-Chin Shih, Melissa Chan, Nicholas S. Kirkby, Ivana Vojnovic, Jane A. Mitchell, Paul C. Armstrong, Timothy D. Warner
Summary: The study demonstrates a synergistic relationship between P2Y(12) receptor antagonists and adenosine signaling, with their efficacy partly dependent on the presence of endogenous adenosine. Despite reported differences in their effects upon adenosine reuptake, both prasugrel and ticagrelor show similar synergistic effects on platelet inhibition in the presence of adenosine or NECA.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Editorial Material
Hematology
Muntadhar Al Moosawi, Aaron Iding, Paul Armstrong, Thita Chiasakul, Robert Campbell, Caterina Casari
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Abhishek Joshi, Lukas E. Schmidt, Sean A. Burnap, Ruifang Lu, Melissa V. Chan, Paul C. Armstrong, Ferheen Baig, Clemens Gutmann, Peter Willeit, Peter Santer, Temo Barwari, Konstantinos Theofilatos, Stefan Kiechl, Johann Willeit, Timothy D. Warner, Anthony Mathur, Manuel Mayr
Summary: This study found that the proteome of platelets is altered during acute myocardial infarction (MI), and the elevated levels of S100A8 and S100A9 proteins are associated with neutrophil abundance. The study also demonstrated the transfer of proteins between platelets and neutrophils, and the negative correlation between plasma S100A8/A9 and platelet reactivity.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Joseph Grech, Melissa Victoria Chan, Chinedu Ochin, Amber Lachapelle, Florian Thibord, Zoe Schneider, Bongani Brian Nkambule, Paul Charles John Armstrong, Catherine Wallace de Melendez, Katherine L. Tucker, Mahdi Garelnabi, Timothy David Warner, Ming-Huei Chen, Andrew Danner Johnson
Summary: Depression is associated with cardiovascular disease, and platelet reactivity is related to the use of antidepressants, especially those affecting serotonin.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pathology
Hannah Hsu, Melissa Chan, Paul C. Armstrong, Marilena Crescente, Dea Donikian, Mayuko Kondo, Timothy Brighton, Vivien Chen, Qiang Chen, David Connor, Joanne Joseph, Marie-Christine Morel-Kopp, William S. Stevenson, Christopher Ward, Timothy D. Warner, David J. Rabbolini
Summary: Identification of disordered platelet function is crucial for peri-operative bleeding management and long-term treatment and prognostic strategies. The Optimul assay, a novel 96-well plate-based aggregometry, showed good agreement with the gold standard diagnostic test LTA in detecting anti-platelet effects, indicating its potential as a useful screening tool for platelet function assessment. This simple and quick assay has the potential to improve access to specialized platelet function testing, especially in regional laboratories where such services are unavailable.
Article
Hematology
Paul C. Armstrong, Harriet E. Allan, Nicholas S. Kirkby, Clemens Gutmann, Abhishek Joshi, Marilena Crescente, Jane A. Mitchell, Manuel Mayr, Timothy D. Warner
Summary: This study developed a method to label platelet age and found that young platelets exhibit different functional and molecular characteristics compared to older platelets, with increased responsiveness and contribution to thrombus formation. The decrease in thrombotic function with age is accompanied by changes in surface protein expression.
Review
Cell Biology
Harriet E. Allan, Ami Vadgama, Paul C. Armstrong, Timothy D. Warner
Summary: Research on the natural aging process of platelets has attracted much attention in recent years. Previous studies have shown an association between the proportion of newly formed platelets in the circulation and the risk of thrombosis. However, these observations were mainly demonstrated in patient groups with underlying systemic changes. Recent technological advances have allowed in-depth analysis of differently aged platelets from healthy individuals, revealing extensive changes in the transcriptome and proteome of aged platelets. These changes result in deteriorated platelet function, impairing their ability to participate in hemostatic responses.
Meeting Abstract
Cardiac & Cardiovascular Systems
Clemens Gutmann, Temo Barwari, Christian Schulte, Bhawana Singh, Konstantinos Theofilatos, Abhishek Joshi, Anna Zampetaki, Melissa Chan, Paul C. Armstrong, Stefan Kiechl, Johann Willeit, Timothy D. Warner, Manuel Mayr
CARDIOVASCULAR RESEARCH
(2022)
