Microsomal prostaglandin E synthase-1 is induced in alzheimer's disease and its deletion mitigates alzheimer's disease-like pathology in a mouse model

Deletion of microsomal prostaglandin E synthase-1 protects neuronal cells from cytotoxic effects of β-amyloid peptide fragment 31–35

(2012) Yukiko Kuroki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Improvement of cognitive function in Alzheimer’s disease model mice by genetic and pharmacological inhibition of the EP4 receptor

(2011) Tatsuya Hoshino et al.   JOURNAL OF NEUROCHEMISTRY

Endothelial microsomal prostaglandin E synthase-1 facilitates neurotoxicity by elevating astrocytic Ca2+ levels

(2011) Takako Takemiya et al.   NEUROCHEMISTRY INTERNATIONAL

Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis

(2011) Y Sasaki et al.   ONCOGENE

Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models

(2010) Shuntaro Hara et al.   BIOCHIMIE

Microsomal prostaglandin E synthase-1 contributes to ischaemic excitotoxicity through prostaglandin E2 EP3 receptors

(2010) Y Ikeda-Matsuo et al.   BRITISH JOURNAL OF PHARMACOLOGY

A fibril-specific, conformation-dependent antibody recognizes a subset of Aβ plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain

(2009) Floyd Sarsoza et al.   ACTA NEUROPATHOLOGICA

Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis

(2009) Daisuke Kamei et al.   BIOCHEMICAL JOURNAL

Microsomal prostaglandin E synthase-2: Cellular distribution and expression in Alzheimer's disease

(2009) Uzma Chaudhry et al.   EXPERIMENTAL NEUROLOGY

Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis

(2009) Y. Kihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytosolic Prostaglandin E Synthase: Expression Patterns in Control and Alzheimer's Disease Brains

(2008) Uzma A. Chaudhry et al.   American Journal of Alzheimers Disease and Other Dementias

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of microglia accumulation in Alzheimer’s disease: therapeutic implications

(2008) Joseph El Khoury et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Elevated microsomal prostaglandin-E synthase–1 in Alzheimer’s disease

(2007) Uzma A. Chaudhry et al.   Alzheimers & Dementia