Article
Cell Biology
Li Li, Haoming Sun, Jionghao Chen, Cong Ding, Xiaojun Yang, Hua Han, Qingzhu Sun
Summary: The therapeutic potential of Orm2, a protein predominantly secreted by hepatocytes, for treating NAFLD and NASH was investigated in this study. The results showed that high Orm2 expression prevented obesity induced by a high-fat diet in mice. The pharmacological administration of recombinant ORM2 protein ameliorated hepatic steatosis, inflammation, hepatocyte injury, and fibrosis in mouse livers afflicted by NAFLD and NASH. Overall, Orm2 plays a critical role in preventing NASH and associated NAFLD in the context of obesity.
Article
Clinical Neurology
Steffen Halbgebauer, Patrick Oeckl, Petra Steinacker, Deniz Yilmazer-Hanke, Sarah Anderl-Straub, Christine von Arnim, Lutz Froelich, Luis Aragao Gomes, Lucrezia Hausner, Andre Huss, Holger Jahn, Jochen Weishaupt, Albert C. Ludolph, Dietmar R. Thal, Markus Otto
Summary: A novel ELISA was established to evaluate beta-synuclein as a potential marker for Alzheimer's disease. The study found increased levels of beta-synuclein in the CSF of some patients, supporting its potential use as a marker of synaptic degeneration. Furthermore, beta-synuclein was localized in glutamatergic synapses, with its expression reduced in AD patients' brain tissue.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Neurosciences
Amber Nous, Mandy Melissa Jane Wittens, Yannick Vermeiren, Peter Paul De Deyn, Christine Van Broeckhoven, Guy Nagels, Ilse Smolders, Sebastiaan Engelborghs
Summary: This study aimed to evaluate the correlation between serum melatonin levels and spinal CSF melatonin levels in AD. The results showed a positive correlation between daytime serum melatonin levels and spinal CSF melatonin levels in AD patients, but no correlation was found between daytime melatonin levels and changes in cognitive impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Claire Bridel, Charisse Somers, Anne Sieben, Annemieke Rozemuller, Ellis Niemantsverdriet, Hanne Struyfs, Yannick Vermeiren, Christine Van Broeckhoven, Peter P. De Deyn, Maria Bjerke, Guy Nagels, Charlotte E. Teunissen, Sebastiaan Engelborghs
Summary: This study examines the relationship between neuropathology and CSF biomarkers in Alzheimer's disease patients, finding that the associations are stronger and more significant with longer intervals between lumbar puncture and death. This suggests that CSF biomarkers may not be well suited for monitoring neuropathological changes at later disease stages.
Article
Multidisciplinary Sciences
Le Gjerum, Birgitte Bo Andersen, Marie Bruun, Anja Hviid Simonsen, Otto Molby Henriksen, Ian Law, Steen Gregers Hasselbalch, Kristian Steen Frederiksen
Summary: The study found that cerebrospinal fluid biomarkers have a higher clinical value in supporting the diagnosis of Alzheimer's disease compared to 2-[F-18]FDG-PET, affecting diagnostic confidence and the need for ancillary investigations significantly.
Article
Neurosciences
Anna Lidia Wojdala, Giovanni Bellomo, Lorenzo Gaetani, Andrea Toja, Elena Chipi, Dandan Shan, Davide Chiasserini, Lucilla Parnetti
Summary: The transition from cerebrospinal fluid (CSF) to plasma provides new avenues for studying molecular phenotypes of Alzheimer's disease (AD). This study evaluated a panel of AD biomarkers in matched CSF and plasma samples, comparing their diagnostic performance and evaluating their trajectories along the AD progression. The findings suggest that a standardized panel of selected plasma markers can facilitate early AD diagnosis and monitoring of disease progression.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Psychiatry
Ying Xiong, Yu-Ting Ruan, Jing Zhao, Yu-Wen Yang, Li-Ping Chen, Ying-Ren Mai, Qun Yu, Zhi-Yu Cao, Fei-Fei Liu, Wang Liao, Jun Liu
Summary: The study confirmed that Magnesium-L-threonate (MgT) can inhibit oxidative stress damage in A beta(25-35)-treated HT22 cells and APP/PS1 mice, by improving cell viability, reducing ROS formation, and apoptosis. MgT also ameliorated cognitive deficits, suppressed hippocampal neuron apoptosis, and regulated the expression of related proteins.
WORLD JOURNAL OF PSYCHIATRY
(2022)
Article
Neurosciences
Unnur D. Teitsdottir, Skarphedinn Halldorsson, Ottar Rolfsson, Sigrun H. Lund, Maria K. Jonsdottir, Jon Snaedal, Petur H. Petersen
Summary: The study identified a significant association between elevated levels of C18 ceramide in cerebrospinal fluid and increased Alzheimer's disease pathology and inflammation, suggesting its potential value as a therapeutic target.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Kirsten E. J. Wesenhagen, Betty M. Tijms, Lynn Boonkamp, Patty L. Hoede, Julie Goossens, Nele Dewit, Philip Scheltens, Eugeen Vanmechelen, Pieter Jelle Visser, Charlotte E. Teunissen
Summary: This study investigated the potential processes related to p-tau subgroups in Alzheimer's disease (AD) and found that the biological heterogeneity in p-tau levels is related to amyloid metabolism and synaptic integrity independent of clinical stage.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Biology
Xiao Chen, Min Zhang, Mukhtar Ahmed, Krishna Mohan Surapaneni, Vishnu Priya Veeraraghavan, Palanisamy Arulselvan
Summary: The study shows that ononin has ameliorative effects on Alzheimer's Disease (AD) by improving cognitive impairment, suppressing neuroinflammation, and oxidative stress in animal models of AD.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Neurosciences
Tyler Saunders, Ciaran Gunn, Kaj Blennow, Hlin Kvartsberg, Henrik Zetterberg, Susan D. Shenkin, Simon R. Cox, Ian J. Deary, Colin Smith, Declan King, Tara Spires-Jones
Summary: Neurogranin (Ng), a post-synaptic protein, has been investigated as a biomarker for Alzheimer's disease (AD) and aging in cerebrospinal fluid (CSF). Our study examined Ng abundance in post-mortem human brain tissue in AD, healthy aging (HA), and mid-life (ML) cohorts. Ng levels were quantified using immunohistochemistry in brain regions associated with cognitive change. The results showed significantly reduced Ng levels in AD compared to HA and ML cases, indicating loss of neurogranin in the brain. Our findings support the use of CSF Ng as a biomarker for AD and cognitive decline in healthy aging.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Cell Biology
Shital Rani, Sudhrita Basu Dhar, Akhil Khajuria, Dikshi Gupta, Pradeep Kumar Jaiswal, Neha Singla, Mandeep Kaur, Gurpal Singh, Ravi Pratap Barnwal
Summary: In order to manage Alzheimer's disease (AD) and improve prognosis and treatment, it is necessary to develop early non-invasive diagnosis methods and identify novel biomarkers. AD has a multifactorial nature and involves complex molecular mechanisms that cause neuronal degeneration. The challenges in early AD detection include patient heterogeneity and the lack of precise diagnosis at the preclinical stage. Several CSF and blood biomarkers, such as tau pathology and cerebral amyloid beta (A beta), have shown excellent diagnostic ability for AD. Intense research efforts are being made to develop ultrasensitive detection techniques and find potent biomarkers for early AD diagnosis.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Immunology
Kaja Nordengen, Bjorn-Eivind Kirsebom, Grit Richter, Lene Palhaugen, Berglind Gisladottir, Nikias Siafarikas, Arne Nakling, Arvid Rongve, Geir Brathen, Goril Rolfseng Grontvedt, Fernando Gonzalez, Knut Waterloo, Kulbhushan Sharma, Thomas Karikari, Eleonora M. Vromen, Betty M. Tijms, Pieter J. Visser, Per Selnes, Milicia G. Kramberger, Bengt Winblad, Kaj Blennow, Tormod Fladby
Summary: Brain innate immune activation is associated with Alzheimer's disease, with varying degrees of activation at different disease stages. In predementia AD, differences in immune activation levels and biomarker profiles may be related to amyloidosis and tau pathology. Changes in certain biomarkers in cerebrospinal fluid may be linked to cognitive preservation or impairment in predementia AD.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Neurosciences
Chang Xu, Li Zhao, Chunbo Dong
Summary: The number of patients with Alzheimer's disease (AD) and non-AD has increased significantly in recent decades. The amyloid cascade hypothesis highlights the role of amyloid-beta protein in the development of AD. CSF A beta(42/40) has been extensively studied and integrated into diagnostic tools for AD, while blood-based A beta(42/40) has also been found to have abnormal levels in sync with CSF biomarker values.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Julian M. Gaitan, Sanjay Asthana, Cynthia M. Carlsson, Corinne D. Engelman, Sterling C. Johnson, Mark A. Sager, Dan Wang, Dena B. Dubal, Ozioma C. Okonkwo
Summary: This study investigated the variation of Klotho concentrations and its association with Alzheimer's disease risk factors. The results showed that Klotho concentrations were higher in KL-VS carriers and in cerebrospinal fluid compared to serum. Females and younger individuals also had higher Klotho levels. These findings suggest that fluid source, KL-VS genotype, age, and sex should be taken into consideration when analyzing the effects of circulating Klotho on brain health.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Immunology
Pu Wang, Xin Yu, Pei-Pei Guan, Jing-Wen Guo, Yue Wang, Yan Zhang, Hang Zhao, Zhan-You Wang
CELLULAR & MOLECULAR IMMUNOLOGY
(2017)
Article
Neurosciences
Chuang Guo, Li-Juan Hao, Zhao-Hui Yang, Rui Chai, Shuai Zhang, Yu Gu, Hui-Ling Gao, Man-Li Zhong, Tao Wang, Jia-Yi Li, Zhan-You Wang
EXPERIMENTAL NEUROLOGY
(2016)
Article
Neurosciences
Yin Li, Ze-Xu Li, Tan Jin, Zhan-You Wang, Pu Zhao
JOURNAL OF ALZHEIMERS DISEASE
(2017)
Article
Biochemistry & Molecular Biology
Ni Zong, Shi-Xin Ma, Zhan-You Wang
JOURNAL OF CHEMICAL NEUROANATOMY
(2017)
Article
Biochemistry & Molecular Biology
Xiaoxu Bi, Pu Wang, Qingjuan Ma, Li Han, Xingbo Wang, Yu Mu, Peipei Guan, Xiaodan Qu, Zhanyou Wang, Xueshi Huang
Article
Biochemistry & Molecular Biology
Xiaoxu Bi, Li Han, Tiange Qu, Yu Mu, Peipei Guan, Xiaodan Qu, Zhanyou Wang, Xueshi Huang
Article
Neurosciences
Chuang Guo, Zhao-Hui Yang, Shuai Zhang, Rui Chai, Han Xue, Yan-Hui Zhang, Jia-Yi Li, Zhan-You Wang
NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Oncology
Yue Wang, Pei-Pei Guan, Xin Yu, Yan-Su Guo, Ying-Jie Zhang, Zhan-You Wang, Pu Wang
Article
Oncology
Shuai Zhang, Rui Chai, Ying-Ying Yang, Shi-Qi Guo, Shan Wang, Tian Guo, Shuang-Feng Xu, Yan-Hui Zhang, Zhan-You Wang, Chuang Guo
Article
Geriatrics & Gerontology
Dan-Dan Li, Wei Zhang, Zhan-You Wang, Pu Zhao
FRONTIERS IN AGING NEUROSCIENCE
(2017)
Article
Geriatrics & Gerontology
Zhuo Wang, Ya-Hong Zhang, Chuang Guo, Hui-Ling Gao, Man-Li Zhong, Ting-Ting Huang, Na-Na Liu, Rui-Fang Guo, Tian Lan, Wei Zhang, Zhan-You Wang, Pu Zhao
FRONTIERS IN AGING NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Yan-Hui Zhang, Da-Wei Wang, Shuang-Feng Xu, Shuai Zhang, Yong-Gang Fan, Ying-Ying Yang, Shi-Qi Guo, Shan Wang, Tian Guo, Zhan-You Wang, Chuang Guo
Article
Engineering, Biomedical
Jing-Wen Guo, Pei-Pei Guan, Wei-Yan Ding, Si-Ling Wang, Xue-Shi Huang, Zhan-You Wang, Pu Wang
Article
Chemistry, Medicinal
Qing-juan Ma, Li Han, Yu Mu, Pei-pei Guan, Hui Lei, Zhan-you Wang, Xue-shi Huang
CHEMICAL & PHARMACEUTICAL BULLETIN
(2017)
Article
Cell Biology
Pu Wang, Zhan-You Wang
AGEING RESEARCH REVIEWS
(2017)