Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage

Revealing a microbial carcinogen

(2019) Rachel M. Bleich et al.   SCIENCE

The human gut bacterial genotoxin colibactin alkylates DNA

(2019) Matthew R. Wilson et al.   SCIENCE

The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells

(2018) Nadège Bossuet-Greif et al.   mBio

Colibactin: More Than a New Bacterial Toxin

(2018) Tiphanie Faïs et al.   Toxins

ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance

(2017) Prabhanshu Tripathi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring

(2017) Li Zha et al.   Nature Chemical Biology

Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917

(2017) Teresa Pérez-Berezo et al.   Nature Communications

Characterization of Polyketide Synthase Machinery from the pks Island Facilitates Isolation of a Candidate Precolibactin

(2016) Li Zha et al.   ACS Chemical Biology

Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin

(2016) Zhong-Rui Li et al.   Nature Chemical Biology

Structural basis for DNA cleavage by the potent antiproliferative agent (–)-lomaiviticin A

(2016) Christina M. Woo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Microbes inside Us and the Race for Colibactin

(2015) Helge B. Bode   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway

(2015) Zhong-Rui Li et al.   CHEMBIOCHEM

Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor

(2015) A. O. Brachmann et al.   CHEMICAL COMMUNICATIONS

Escherichia coli  ClbS is a colibactin resistance protein

(2015) Nadège Bossuet-Greif et al.   MOLECULAR MICROBIOLOGY

Colibactin: understanding an elusive gut bacterial genotoxin

(2015) Emily P. Balskus   NATURAL PRODUCT REPORTS

The colibactin warhead crosslinks DNA

(2015) Maria I. Vizcaino et al.   Nature Chemistry

Isolation of a Metabolite from the pks Island Provides Insights into Colibactin Biosynthesis and Activity

(2015) Carolyn A. Brotherton et al.   ORGANIC LETTERS

Small molecules from the human microbiota

(2015) M. S. Donia et al.   SCIENCE

Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety

(2015) Xiaoying Bian et al.   Chemical Science

Gut Symbionts from Distinct Hosts Exhibit Genotoxic Activity via Divergent Colibactin Biosynthesis Pathways

(2014) Philipp Engel et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics

(2014) Mohamed S. Donia et al.   CELL

Specialized Metabolites from the Microbiome in Health and Disease

(2014) Gil Sharon et al.   Cell Metabolism

Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype

(2014) Antony Cougnoux et al.   GUT

Comparative Metabolomics and Structural Characterizations Illuminate Colibactin Pathway-Dependent Small Molecules

(2014) Maria I. Vizcaino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The cytotoxicity of (−)-lomaiviticin A arises from induction of double-strand breaks in DNA

(2014) Laureen C. Colis et al.   Nature Chemistry

In Vivo Evidence for a Prodrug Activation Mechanism during Colibactin Maturation

(2013) Xiaoying Bian et al.   CHEMBIOCHEM

The genusPseudovibriocontains metabolically versatile bacteria adapted for symbiosis

(2013) Vladimir Bondarev et al.   ENVIRONMENTAL MICROBIOLOGY

A Prodrug Resistance Mechanism Is Involved in Colibactin Biosynthesis and Cytotoxicity

(2013) Carolyn A. Brotherton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer

(2013) Emmanuel Buc et al.   PLoS One

Escherichia coli Producing Colibactin Triggers Premature and Transmissible Senescence in Mammalian Cells

(2013) Thomas Secher et al.   PLoS One

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

Molecular Insights into the Biosynthesis of Guadinomine: A Type III Secretion System Inhibitor

(2012) Tracy C. Holmes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The siderophore yersiniabactin binds copper to protect pathogens during infection

(2012) Kaveri S Chaturvedi et al.   Nature Chemical Biology

The human microbiome: at the interface of health and disease

(2012) Ilseung Cho et al.   NATURE REVIEWS GENETICS

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

(2012) J. C. Arthur et al.   SCIENCE

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Activation of DNA Carbon−Hydrogen Bonds by Metal Complexes

(2010) Marguerite Pitié et al.   CHEMICAL REVIEWS

Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

(2010) G. Cuevas-Ramos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA